DE69332636T2 - Antidepressant and anti-Parkinsonian compounds - Google Patents

Antidepressant and anti-Parkinsonian compounds

Info

Publication number
DE69332636T2
DE69332636T2 DE69332636T DE69332636T DE69332636T2 DE 69332636 T2 DE69332636 T2 DE 69332636T2 DE 69332636 T DE69332636 T DE 69332636T DE 69332636 T DE69332636 T DE 69332636T DE 69332636 T2 DE69332636 T2 DE 69332636T2
Authority
DE
Germany
Prior art keywords
compounds
parkinsonian
antidepressant
chem
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332636T
Other languages
German (de)
Other versions
DE69332636D1 (en
Inventor
Peter Moldt
Jorgen Scheel-Krueger
Leif Helth Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK921541A external-priority patent/DK154192D0/en
Application filed by Neurosearch AS filed Critical Neurosearch AS
Application granted granted Critical
Publication of DE69332636D1 publication Critical patent/DE69332636D1/en
Publication of DE69332636T2 publication Critical patent/DE69332636T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Abstract

The present invention discloses compounds of the formula <CHEM> any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R<3>, and R<4> each have the meanings set forth in the specification. The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.
DE69332636T 1992-12-23 1993-12-20 Antidepressant and anti-Parkinsonian compounds Expired - Lifetime DE69332636T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK921541A DK154192D0 (en) 1992-12-23 1992-12-23 HETEROCYCLIC COMPOUNDS
US08/093,182 US5374636A (en) 1992-12-23 1993-07-16 2,3-trans-disubstituted tropane compounds which have useful pharmaceutical utility

Publications (2)

Publication Number Publication Date
DE69332636D1 DE69332636D1 (en) 2003-02-20
DE69332636T2 true DE69332636T2 (en) 2003-09-11

Family

ID=26065882

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332636T Expired - Lifetime DE69332636T2 (en) 1992-12-23 1993-12-20 Antidepressant and anti-Parkinsonian compounds

Country Status (9)

Country Link
EP (1) EP0604354B1 (en)
JP (1) JP3841449B2 (en)
AT (1) ATE231147T1 (en)
AU (1) AU672052B2 (en)
CA (1) CA2112084C (en)
DE (1) DE69332636T2 (en)
FI (1) FI935800A (en)
NO (1) NO303578B1 (en)
NZ (1) NZ250515A (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU673265B2 (en) * 1993-05-18 1996-10-31 Wake Forest University Treatment process with biologically active tropane derivatives
SK280875B6 (en) * 1994-04-19 2000-08-14 Neurosearch A/S Tropane derivatives, method of their preparation, pharmaceutical compositions, use of these tropane derivatives for the preparation of medicaments
RU2157372C2 (en) * 1995-10-13 2000-10-10 Нюросерч А/С Derivatives of 8-azabicyclo[3,2,1]oct-2-ene, method of their synthesis, pharmaceutical composition, method of drug preparing, methods of inhibition of reuptake of monoamine neuromediating agent, especially, serotonin
PT885220E (en) 1996-02-22 2001-11-30 Neurosearch As DERIVATIVES OF TROPANE TO ITS PREPARATION AND UTILIZATION
AU2609999A (en) * 1998-01-28 1999-08-16 Neurosearch A/S 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and use of 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and unlabelled form
WO1999065492A1 (en) * 1998-06-19 1999-12-23 Eli Lilly And Company Inhibition of serotonin reuptake
DK1257541T3 (en) * 2000-01-11 2009-01-19 Molecular Insight Pharm Inc Pharmacophoric drugs
WO2003014114A2 (en) * 2001-08-08 2003-02-20 Neurosearch A/S Substituted amine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CA2458801A1 (en) * 2001-08-17 2003-02-27 President And Fellows Of Harvard College Therapeutic tropane compounds
EP1453511B1 (en) 2001-11-30 2006-11-15 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
AU2004212166B2 (en) 2003-02-12 2010-07-29 Neurosearch A/S 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CN100551924C (en) * 2003-02-12 2009-10-21 神经研究公司 8-aza-bicyclo [3.2.1] Octane derivatives and they purposes as monoamine neurotransmitter re-uptake
MXPA05008315A (en) 2003-02-12 2005-09-20 Neurosearch As Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors.
EP1675591B1 (en) 2003-10-16 2011-08-10 NeuroSearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor
WO2007028770A1 (en) * 2005-09-05 2007-03-15 Neurosearch A/S Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease
EP1779851A1 (en) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Treatment of diabetes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US3901892A (en) * 1973-12-14 1975-08-26 Sterling Drug Inc 1,3-ethanoindeno(2,1-c)-pyridines and 1,3-ethanobenz(g)isoquinolines
FR2276823A1 (en) * 1974-07-04 1976-01-30 Roussel Uclaf NEW DIBENZO (B.E) THIEPINE DERIVATIVES AND THEIR SALTS, PROCESS FOR PREPARATION AND APPLICATION AS MEDICINAL PRODUCTS FOR SUCH PRODUCTS
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
EP0398578B1 (en) * 1989-05-17 1997-03-12 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents
DK198590D0 (en) * 1990-08-21 1990-08-21 Novo Nordisk As HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE
ATE182794T1 (en) * 1991-11-15 1999-08-15 Res Triangle Inst COCAINE RECEPTOR BINDING LIGANDS
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
US5268480A (en) * 1992-09-22 1993-12-07 Mayo Foundation For Medical Education And Research Cocaine analogs

Also Published As

Publication number Publication date
NO934761D0 (en) 1993-12-22
ATE231147T1 (en) 2003-02-15
CA2112084C (en) 2002-06-11
EP0604354A3 (en) 1995-02-08
AU672052B2 (en) 1996-09-19
FI935800A (en) 1994-06-24
FI935800A0 (en) 1993-12-22
NO303578B1 (en) 1998-08-03
EP0604354B1 (en) 2003-01-15
AU5236293A (en) 1994-07-07
JPH06293758A (en) 1994-10-21
DE69332636D1 (en) 2003-02-20
NO934761L (en) 1994-06-24
EP0604354A2 (en) 1994-06-29
CA2112084A1 (en) 1994-06-24
NZ250515A (en) 1996-09-25
JP3841449B2 (en) 2006-11-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition