DE69325393D1 - PHARMACEUTICAL COMPOSITIONS AND METHOD USING ISOBUTYRAMIDE FOR THE TREATMENT OF BETAGLOBIN DISEASES - Google Patents

PHARMACEUTICAL COMPOSITIONS AND METHOD USING ISOBUTYRAMIDE FOR THE TREATMENT OF BETAGLOBIN DISEASES

Info

Publication number
DE69325393D1
DE69325393D1 DE69325393T DE69325393T DE69325393D1 DE 69325393 D1 DE69325393 D1 DE 69325393D1 DE 69325393 T DE69325393 T DE 69325393T DE 69325393 T DE69325393 T DE 69325393T DE 69325393 D1 DE69325393 D1 DE 69325393D1
Authority
DE
Germany
Prior art keywords
isobutyramide
treatment
betaglobin
diseases
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69325393T
Other languages
German (de)
Other versions
DE69325393T2 (en
Inventor
Susan Perrine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cincinnati Childrens Hospital Medical Center
Childrens Hospital Oakland Research Center
Original Assignee
Cincinnati Childrens Hospital Medical Center
Childrens Hospital Oakland Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cincinnati Childrens Hospital Medical Center, Childrens Hospital Oakland Research Center filed Critical Cincinnati Childrens Hospital Medical Center
Application granted granted Critical
Publication of DE69325393D1 publication Critical patent/DE69325393D1/en
Publication of DE69325393T2 publication Critical patent/DE69325393T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention relates to treatment of betaglobin disorders, such as sickle-cell anemia and beta-thalassemia, by administering compositions of isobutyramide.
DE69325393T 1992-03-17 1993-03-17 PHARMACEUTICAL COMPOSITIONS AND METHOD USING ISOBUTYRAMIDE FOR THE TREATMENT OF BETAGLOBIN DISEASES Expired - Fee Related DE69325393T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/852,511 US5439939A (en) 1992-03-17 1992-03-17 Pharmaceutical compositions and methods using isobutyramide for treating betaglobin disorders
PCT/US1993/002389 WO1993018761A1 (en) 1992-03-17 1993-03-17 Pharmaceutical compositions and methods using isobutyramide for treating betaglobin disorders

Publications (2)

Publication Number Publication Date
DE69325393D1 true DE69325393D1 (en) 1999-07-22
DE69325393T2 DE69325393T2 (en) 1999-12-16

Family

ID=25313524

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69325393T Expired - Fee Related DE69325393T2 (en) 1992-03-17 1993-03-17 PHARMACEUTICAL COMPOSITIONS AND METHOD USING ISOBUTYRAMIDE FOR THE TREATMENT OF BETAGLOBIN DISEASES

Country Status (10)

Country Link
US (1) US5439939A (en)
EP (1) EP0697862B1 (en)
AT (1) ATE181235T1 (en)
AU (1) AU3810693A (en)
DE (1) DE69325393T2 (en)
DK (1) DK0697862T3 (en)
ES (1) ES2135470T3 (en)
GR (1) GR3031241T3 (en)
SG (1) SG48764A1 (en)
WO (1) WO1993018761A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910624B1 (en) 1995-03-03 2011-03-22 The Trustees Of Boston University Compositions for the treatment of blood disorders
IT1273628B (en) * 1993-06-04 1997-07-08 Emerging Pharmaceutical Techno PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TALASSEMIA CONTAINING BUTYRRIC ACID DERIVATIVES AND IN PARTICULAR ISOBUTYRAMIDE
US5569675A (en) * 1994-03-07 1996-10-29 Bar Ilan University Methods of using carboxylic acid esters to increase fetal-hemoglobin levels
US5700640A (en) * 1994-09-16 1997-12-23 Basf Aktiengesellschaft Inducers of gamma globin gene expression and screening assays therefor
US6011000A (en) * 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
US6822267B1 (en) * 1997-08-20 2004-11-23 Advantest Corporation Signal transmission circuit, CMOS semiconductor device, and circuit board
CA2324426A1 (en) 1998-02-11 1999-08-19 Douglas V. Faller Compositions and methods for the treatment of cystic fibrosis
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
FR2847817B1 (en) * 2002-11-28 2006-11-10 Centre Nat Rech Scient USE OF A HISTONE DEACETYLASE INHIBITOR FOR THE TREATMENT OF MUSCLE DYSTROPHIES
CA2518318A1 (en) 2003-03-17 2004-09-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2005011696A1 (en) * 2003-08-01 2005-02-10 Fibrogen, Inc. Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
EP1824831A2 (en) 2004-12-16 2007-08-29 Takeda San Diego, Inc. Histone deacetylase inhibitors
JP2008540574A (en) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド Histone deacetylase inhibitor
CN101263121A (en) 2005-07-14 2008-09-10 塔克达圣地亚哥公司 Histone deacetylase inhibitors
US20070185045A1 (en) * 2006-02-06 2007-08-09 Ratcliffe Peter J Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
US20110086869A1 (en) 2009-09-24 2011-04-14 The Trustees Of Boston University Methods for treating viral disorders
CN102802412A (en) 2009-12-08 2012-11-28 海玛奎斯特医药公司 Methods and low dose regimens for treating red blood cell disorders
WO2011113013A2 (en) 2010-03-11 2011-09-15 Hemaquest Pharmaceuticals, Inc. Methods and compositions for treating viral or virally-induced conditions
US10039813B2 (en) 2012-02-07 2018-08-07 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
US9724396B2 (en) 2013-03-15 2017-08-08 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
WO2016064815A1 (en) * 2014-10-20 2016-04-28 Massachusetts Institute Of Technology Functional ghrelin receptor antagonism during pregnancy to prevent stress-associated mental illness in offspring and mothers
WO2016138099A1 (en) 2015-02-24 2016-09-01 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
KR20220034736A (en) 2019-05-31 2022-03-18 비락타 서브시디어리 인크. How to use histone deacetylase inhibitors to treat virus-associated cancer
AU2022370354A1 (en) 2021-10-19 2024-05-30 Akirabio, Inc. Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482571A (en) * 1982-06-21 1984-11-13 University Of Pittsburgh Sickle cell anemia treatment and compound
US5025029A (en) * 1986-10-10 1991-06-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
US4822821A (en) * 1986-10-10 1989-04-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
SG86966A1 (en) * 1988-11-29 2002-03-19 Childrens Hosp Medical Center Medicament for augmenting fetal hemoglobin

Also Published As

Publication number Publication date
EP0697862B1 (en) 1999-06-16
DK0697862T3 (en) 1999-12-13
ES2135470T3 (en) 1999-11-01
ATE181235T1 (en) 1999-07-15
SG48764A1 (en) 1998-05-18
EP0697862A4 (en) 1996-05-29
US5439939A (en) 1995-08-08
DE69325393T2 (en) 1999-12-16
EP0697862A1 (en) 1996-02-28
AU3810693A (en) 1993-10-21
WO1993018761A1 (en) 1993-09-30
GR3031241T3 (en) 1999-12-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee