DE69325393D1 - PHARMACEUTICAL COMPOSITIONS AND METHOD USING ISOBUTYRAMIDE FOR THE TREATMENT OF BETAGLOBIN DISEASES - Google Patents

PHARMACEUTICAL COMPOSITIONS AND METHOD USING ISOBUTYRAMIDE FOR THE TREATMENT OF BETAGLOBIN DISEASES

Info

Publication number
DE69325393D1
DE69325393D1 DE69325393T DE69325393T DE69325393D1 DE 69325393 D1 DE69325393 D1 DE 69325393D1 DE 69325393 T DE69325393 T DE 69325393T DE 69325393 T DE69325393 T DE 69325393T DE 69325393 D1 DE69325393 D1 DE 69325393D1
Authority
DE
Germany
Prior art keywords
isobutyramide
treatment
betaglobin
diseases
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69325393T
Other languages
German (de)
Other versions
DE69325393T2 (en
Inventor
Susan Perrine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cincinnati Childrens Hospital Medical Center
Childrens Hospital Oakland Research Center
Original Assignee
Cincinnati Childrens Hospital Medical Center
Childrens Hospital Oakland Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cincinnati Childrens Hospital Medical Center, Childrens Hospital Oakland Research Center filed Critical Cincinnati Childrens Hospital Medical Center
Application granted granted Critical
Publication of DE69325393D1 publication Critical patent/DE69325393D1/en
Publication of DE69325393T2 publication Critical patent/DE69325393T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention relates to treatment of betaglobin disorders, such as sickle-cell anemia and beta-thalassemia, by administering compositions of isobutyramide.
DE69325393T 1992-03-17 1993-03-17 PHARMACEUTICAL COMPOSITIONS AND METHOD USING ISOBUTYRAMIDE FOR THE TREATMENT OF BETAGLOBIN DISEASES Expired - Fee Related DE69325393T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/852,511 US5439939A (en) 1992-03-17 1992-03-17 Pharmaceutical compositions and methods using isobutyramide for treating betaglobin disorders
PCT/US1993/002389 WO1993018761A1 (en) 1992-03-17 1993-03-17 Pharmaceutical compositions and methods using isobutyramide for treating betaglobin disorders

Publications (2)

Publication Number Publication Date
DE69325393D1 true DE69325393D1 (en) 1999-07-22
DE69325393T2 DE69325393T2 (en) 1999-12-16

Family

ID=25313524

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69325393T Expired - Fee Related DE69325393T2 (en) 1992-03-17 1993-03-17 PHARMACEUTICAL COMPOSITIONS AND METHOD USING ISOBUTYRAMIDE FOR THE TREATMENT OF BETAGLOBIN DISEASES

Country Status (10)

Country Link
US (1) US5439939A (en)
EP (1) EP0697862B1 (en)
AT (1) ATE181235T1 (en)
AU (1) AU3810693A (en)
DE (1) DE69325393T2 (en)
DK (1) DK0697862T3 (en)
ES (1) ES2135470T3 (en)
GR (1) GR3031241T3 (en)
SG (1) SG48764A1 (en)
WO (1) WO1993018761A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910624B1 (en) 1995-03-03 2011-03-22 The Trustees Of Boston University Compositions for the treatment of blood disorders
IT1273628B (en) * 1993-06-04 1997-07-08 Emerging Pharmaceutical Techno PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TALASSEMIA CONTAINING BUTYRRIC ACID DERIVATIVES AND IN PARTICULAR ISOBUTYRAMIDE
US5569675A (en) * 1994-03-07 1996-10-29 Bar Ilan University Methods of using carboxylic acid esters to increase fetal-hemoglobin levels
US5700640A (en) * 1994-09-16 1997-12-23 Basf Aktiengesellschaft Inducers of gamma globin gene expression and screening assays therefor
US6011000A (en) * 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
US6822267B1 (en) * 1997-08-20 2004-11-23 Advantest Corporation Signal transmission circuit, CMOS semiconductor device, and circuit board
AU774861B2 (en) 1998-02-11 2004-07-08 Douglas V Faller Compositions and methods for the treatment of cystic fibrosis
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
FR2847817B1 (en) * 2002-11-28 2006-11-10 Centre Nat Rech Scient USE OF A HISTONE DEACETYLASE INHIBITOR FOR THE TREATMENT OF MUSCLE DYSTROPHIES
CA2518318A1 (en) 2003-03-17 2004-09-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP1658074B1 (en) * 2003-08-01 2012-11-07 Fibrogen, Inc. Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
JP2008524246A (en) 2004-12-16 2008-07-10 タケダ サン ディエゴ インコーポレイテッド Histone deacetylase inhibitor
JP2008540574A (en) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド Histone deacetylase inhibitor
EA200800321A1 (en) 2005-07-14 2008-06-30 Такеда Сан Диего, Инк. HISTONDEACETYLASE INHIBITORS
US20070185045A1 (en) * 2006-02-06 2007-08-09 Ratcliffe Peter J Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
WO2011038224A1 (en) 2009-09-24 2011-03-31 Trustees Of Boston University Methods for treating viral disorders
US8618068B2 (en) 2009-12-08 2013-12-31 Trustees Of Boston University Methods and low dose regimens for treating red blood cell disorders
WO2011113013A2 (en) 2010-03-11 2011-09-15 Hemaquest Pharmaceuticals, Inc. Methods and compositions for treating viral or virally-induced conditions
WO2013119800A1 (en) 2012-02-07 2013-08-15 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
WO2014144231A1 (en) 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
US20160106821A1 (en) * 2014-10-20 2016-04-21 Massachusetts Institute Of Technology Functional ghrelin receptor antagonism during pregnancy to prevent stress-associated mental illness in offspring and mothers
US10317418B2 (en) 2015-02-24 2019-06-11 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
CN114206447A (en) 2019-05-31 2022-03-18 维拉克塔附属公司 Methods of treating virus-associated cancers with histone deacetylase inhibitors
JP2024539267A (en) 2021-10-19 2024-10-28 アキラバイオ， インコーポレイテッド Compositions Comprising 2'-Deoxycytidine Analogs and Their Use for Treating Sickle Cell Disease, Thalassemia and Cancer - Patent application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482571A (en) * 1982-06-21 1984-11-13 University Of Pittsburgh Sickle cell anemia treatment and compound
US4822821A (en) * 1986-10-10 1989-04-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
US5025029A (en) * 1986-10-10 1991-06-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
SG86966A1 (en) * 1988-11-29 2002-03-19 Childrens Hosp Medical Center Medicament for augmenting fetal hemoglobin

Also Published As

Publication number Publication date
EP0697862A1 (en) 1996-02-28
DE69325393T2 (en) 1999-12-16
DK0697862T3 (en) 1999-12-13
AU3810693A (en) 1993-10-21
US5439939A (en) 1995-08-08
GR3031241T3 (en) 1999-12-31
SG48764A1 (en) 1998-05-18
ES2135470T3 (en) 1999-11-01
ATE181235T1 (en) 1999-07-15
EP0697862B1 (en) 1999-06-16
EP0697862A4 (en) 1996-05-29
WO1993018761A1 (en) 1993-09-30

Similar Documents

Publication Publication Date Title
DE69325393D1 (en) PHARMACEUTICAL COMPOSITIONS AND METHOD USING ISOBUTYRAMIDE FOR THE TREATMENT OF BETAGLOBIN DISEASES
UA48939C2 (en) Disubstituted furanons, methods for synthesis, pharmaceutical composition, method for treating inflammatory disease, intermediate substances
DE69104991D1 (en) MOMETASON FUROATE MONOHYDRATE, METHOD FOR THE PRODUCTION THEREOF AND THE CONTAINING PHARMACEUTICAL COMPOSITIONS.
BR9502707A (en) Compound pharmaceutical composition and method for treating a condition
ATE120961T1 (en) CONCENTRATES OF ACTIVE COMPOUNDS AND COMBINATIONS OF ACTIVE COMPOUNDS, THEIR PROCESS OF PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THE CONCENTRATES OR THE COMBINATIONS.
EE200000318A (en) Novel compounds
UA29494C2 (en) Humanized antibodies, methods for producing thereof, a method for treatment of Crohns disease, a method for treatment OF disseminated sclerosis, pharmaceutical composition
EP0397060A3 (en) Maleinimide derivatives and their use as medicines
ATE58534T1 (en) 2-PYRIMIDINYL-L-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICALS CONTAINING THEM.
ATE15798T1 (en) HETEROCYCLIC CARBOXAMIDES, PREPARATIONS CONTAINING SUCH COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND METHODS FOR THE TREATMENT THEREOF.
DE68914488D1 (en) 2- (2-Hydroxy-3-phenoxypropylamino) ethylphenoxyacetamide, process and intermediates for their preparation.
IT1265101B1 (en) DERIVATIVES OF 2-AMINO-4-PHENYL-4-BUTYRIC BONE ACID
DE69121502D1 (en) PROCESS FOR THE PRESENTATION OF ASPARTAM FROM A DIKETOPIPERAZINE AND NEW INTERMEDIATE PRODUCTS AND DERIVATIVES THEREFOR
DE602004002394D1 (en) (3-ä3 - '(2,4-BIS-TRIFLUOROMETHYL-BENZYL) - (5-ETHYL-PYRIMIDIN-2-YL) -AMINOÜ-PROPOXYU-PHENYL) ACETIC ACID AND RELATED COMPOUNDS AS MODULATORS OF PPARS AND METHOD FOR THE TREATMENT OF METABOLIC DISORDERS
ATE121949T1 (en) 5,10-METHYLENETETRAHYDROFOLIC ACID CYCLODEXTRIN INCLUSION COMPOUNDS.
ATE225171T1 (en) AMINO ACID DERIVATIVES FOR THE TREATMENT OF STROKE
DE69429856D1 (en) SUBSTITUTED CAPROLACTAME AND THEIR DERIVATIVES USED FOR TREATING HIV DISEASE
ATE151774T1 (en) CYCLOPENTANPERHYDROPHENANTHRENE-17-BETA-(3-FURYL - 3-DERIVATIVES AND PHARMACEUTICAL PREPARATIONS THEREOF FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
ATE417831T1 (en) CERAMIDE-LIKE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS ANTI-TUMOR AGENTS
ATE421961T1 (en) PIPERIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE CONTAINING THESE DERIVATIVES
DE69619868D1 (en) PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF
EP0053695A3 (en) Esters of n-pyrimidinyl-carbamic acid, method of preparing them and pharmaceutical compositions containing them
ATE182886T1 (en) NEW PYRIDINE OR PYRIDAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
ATE69809T1 (en) LEUKOTRIAN ANTAGONISTS, PROCESS FOR THEIR PRODUCTION, THEIR APPLICATION FOR THE TREATMENT OF DISEASES.
IT1258788B (en) SULPHURATED DERIVATIVES OF BILIARY ACIDS

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee