DE69232287T2 - Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards - Google Patents

Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards

Info

Publication number
DE69232287T2
DE69232287T2 DE69232287T DE69232287T DE69232287T2 DE 69232287 T2 DE69232287 T2 DE 69232287T2 DE 69232287 T DE69232287 T DE 69232287T DE 69232287 T DE69232287 T DE 69232287T DE 69232287 T2 DE69232287 T2 DE 69232287T2
Authority
DE
Germany
Prior art keywords
myocard
composition
reperfusion damage
adenosine
reducing reperfusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232287T
Other languages
English (en)
Other versions
DE69232287D1 (de
Inventor
Mervyn B Forman
Edwin K Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Publication of DE69232287D1 publication Critical patent/DE69232287D1/de
Application granted granted Critical
Publication of DE69232287T2 publication Critical patent/DE69232287T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Dental Preparations (AREA)
DE69232287T 1991-05-22 1992-03-26 Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards Expired - Fee Related DE69232287T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/704,058 US5206222A (en) 1991-05-22 1991-05-22 Methods for the reduction of myocardial reperfusion injury
PCT/US1992/002528 WO1992020346A1 (en) 1991-05-22 1992-03-26 Method and composition to reduce myocardial reperfusion injury

Publications (2)

Publication Number Publication Date
DE69232287D1 DE69232287D1 (de) 2002-01-24
DE69232287T2 true DE69232287T2 (de) 2002-07-25

Family

ID=24827883

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232287T Expired - Fee Related DE69232287T2 (de) 1991-05-22 1992-03-26 Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards

Country Status (7)

Country Link
US (1) US5206222A (de)
EP (1) EP0589964B1 (de)
JP (1) JPH06510751A (de)
AT (1) ATE210449T1 (de)
CA (1) CA2103458C (de)
DE (1) DE69232287T2 (de)
WO (1) WO1992020346A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
GB9421133D0 (en) * 1994-10-20 1994-12-07 Glaxo Group Ltd Medicaments
US5629298A (en) * 1995-03-13 1997-05-13 University Of Massachusetts Medical Center Adenosine as a positive inotrop in the compromised heart
CA2299320A1 (en) * 1997-09-22 1999-04-01 Item Development Ab New method of treatment
EP1021195A1 (de) * 1997-10-07 2000-07-26 The Regents Of The University Of California Behandlung okklusiver peripheral-gefässkrankheiten und koronarkrankheiten mit kombinationen aus heparin und adenosin-a2-agonisten, oder mit adenosin
US6015384A (en) * 1998-08-31 2000-01-18 Acuson Corporation Ultrasonic system and method for tissue viability imaging
BR0010653A (pt) * 1999-03-23 2002-02-05 Univ James Cook Parada, proteção e preservação de orgãos
US6368573B1 (en) * 1999-11-15 2002-04-09 King Pharmaceuticals Research And Development, Inc. Diagnostic uses of 2-substituted adenosine carboxamides
US6599283B1 (en) * 2001-05-04 2003-07-29 Cv Therapeutics, Inc. Method of preventing reperfusion injury
DE10258770B4 (de) * 2001-12-18 2005-02-10 F. Hoffmann-La Roche Ag Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
GB2412067B (en) * 2002-12-23 2007-11-14 Global Cardiac Solutions Pty L Organ preconditioning, arrest, protection, preservation and recovery (2)
AU2003291847B2 (en) * 2002-12-23 2010-12-02 Hibernation Therapeutics, A Kf Llc Organ preconditioning, arrest, protection, preservation and recovery
EA011826B1 (ru) * 2004-05-26 2009-06-30 Инотек Фармасьютикалз Корпорейшн Пуриновые производные в качестве агонистов аденозиновых арецепторов и способы их применения
US20110076255A1 (en) * 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
CA2627319A1 (en) * 2005-11-30 2007-06-07 Prakash Jagtap Purine derivatives and methods of use thereof
EP2079301B1 (de) * 2006-05-29 2017-03-15 Hibernation Therapeutics, a KF LLC Verbesserte gewebeerhaltung
ES2539762T3 (es) * 2006-07-25 2015-07-03 Hibernation Therapeutics, A Kf Llc Tratamiento de traumatismos
AU2008222595B2 (en) * 2007-03-02 2014-03-27 Hibernation Therapeutics, A Kf Llc Transplants
WO2008134740A1 (en) * 2007-04-30 2008-11-06 The Trustees Of The University Of Pennsylvania System and method of resuscitation of a mammal
US20090136460A1 (en) * 2007-07-10 2009-05-28 Vanderbilt University Use of adenosine receptor ligands to promote cell adhesion in cell-based therapies
CN101808509A (zh) * 2007-07-25 2010-08-18 低温药理有限公司 改进的器官保护、维护和康复
US20090218349A1 (en) * 2008-02-29 2009-09-03 Silgan Containers Corporation Vacuum container with protective features
US8877732B2 (en) 2010-01-11 2014-11-04 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
MX2012010724A (es) 2010-03-26 2012-11-12 Inotek Pharmaceuticals Corp Metodo para reducir la presion intraocular en seres humanos empleando n6-ciclopentiladenosina (cpa), derivados de cpa o profarmacos de los mismos.
DK2807178T3 (en) 2012-01-26 2017-09-04 Inotek Pharmaceuticals Corp Anhydrous polymorphs of (2R, 3S, 4R, 5R) -5- (6- (cyclopentylamino) -9H-purin-9-yl) -3,4-dihydroxytetrahydrofuran-2-yl) methyl nitrate and processes for their preparation
SG11201506882YA (en) 2013-03-15 2015-09-29 Inotek Pharmaceuticals Corp Ophthalmic formulations
WO2015006830A1 (en) 2013-07-17 2015-01-22 Hts Therapeutics Pty Ltd A method for organ arrest, protection and preservation and reducing tissue injury

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0696534B2 (ja) * 1986-04-25 1994-11-30 ヘキストジヤパン株式会社 抗痴呆剤
JPH06104666B2 (ja) * 1986-09-30 1994-12-21 チバ―ガイギー アクチェンゲゼルシャフト ２―置換―ｅ―縮合―〔１，２，４〕トリアゾロ〔１，５―ｃ〕ピリミジン類及びそれを含有する医薬組成物
EP0267878A1 (de) * 1986-11-14 1988-05-18 Ciba-Geigy Ag N9-Cyclopentylsubstituierte Adeninderivate
US5034381A (en) * 1988-01-07 1991-07-23 Ciba-Geigy Corporation 2-(substituted amino) adenosines as antihypertensives
AU3820989A (en) * 1988-08-02 1990-02-08 Ciba-Geigy Ag 7-amino-3-beta-d-ribofuranosyl-3h-imidazo(4,5-b) pyridin-5-amine derivatives
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物

Also Published As

Publication number Publication date
ATE210449T1 (de) 2001-12-15
US5206222A (en) 1993-04-27
JPH06510751A (ja) 1994-12-01
EP0589964B1 (de) 2001-12-12
DE69232287D1 (de) 2002-01-24
EP0589964A4 (en) 1994-05-25
CA2103458C (en) 2000-11-14
WO1992020346A1 (en) 1992-11-26
CA2103458A1 (en) 1992-11-23
EP0589964A1 (de) 1994-04-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee