DE69216888T2 - The equatorially linked beta 1-4 polyuronates and their use to stimulate the cytokines - Google Patents
The equatorially linked beta 1-4 polyuronates and their use to stimulate the cytokinesInfo
- Publication number
- DE69216888T2 DE69216888T2 DE69216888T DE69216888T DE69216888T2 DE 69216888 T2 DE69216888 T2 DE 69216888T2 DE 69216888 T DE69216888 T DE 69216888T DE 69216888 T DE69216888 T DE 69216888T DE 69216888 T2 DE69216888 T2 DE 69216888T2
- Authority
- DE
- Germany
- Prior art keywords
- cytokines
- polysaccharides
- present
- monocytes
- chitosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
The present invention is directed to a material and method for the stimulation of the production of cytokines. Several polysaccharides, including polymers of different size of beta 1-4 linked D-mannuronic acid (poly-M and M-blocks), chitosan and cellulose oxidized in C-6 position (C60XY) induce human monocytes to produce the cytokines. Preferably, the molecular weights of poly-M and chitosan are above 50,000 and 20,000 respectively. Pretreatment of the monocytes with IFN- gamma increases the cytokine production from monocytes stimulated with all polysaccharides tested. The subject polysaccharides worked in vivo and in vitro. The present invention has therapeutic utility as vaccine adjuvants and components. Therapeutic compositions comprising biologically active quantities of the compositions of the present invention may be employed to potentiate antibody production in response to vaccine antigens. Anti-tumor, anti-bacteriological, anti-fungal and anti-viral effects may be expected.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/676,103 US5169840A (en) | 1991-03-27 | 1991-03-27 | Diequatorially bound β-1, 4 polyuronates and use of same for cytokine stimulation |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69216888D1 DE69216888D1 (en) | 1997-03-06 |
DE69216888T2 true DE69216888T2 (en) | 1997-06-12 |
Family
ID=24713242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69216888T Expired - Lifetime DE69216888T2 (en) | 1991-03-27 | 1992-03-24 | The equatorially linked beta 1-4 polyuronates and their use to stimulate the cytokines |
Country Status (6)
Country | Link |
---|---|
US (1) | US5169840A (en) |
EP (1) | EP0506326B1 (en) |
JP (1) | JP3523654B2 (en) |
AT (1) | ATE147984T1 (en) |
DE (1) | DE69216888T2 (en) |
DK (1) | DK0506326T3 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE241984T1 (en) * | 1993-03-26 | 2003-06-15 | Franciscus Wilhelmus He Merkus | PHARMACEUTICAL COMPOSITIONS FOR INTRANASAL ADMINISTRATION OF APOMORPHINE |
GB9419979D0 (en) * | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
GB9522351D0 (en) * | 1995-11-01 | 1996-01-03 | Medeva Holdings Bv | Vaccine compositions |
NO305033B1 (en) * | 1997-05-09 | 1999-03-22 | Algipharma As | Process for the preparation of uric acid blocks from alginate |
GB2325233B (en) * | 1997-05-16 | 2001-07-18 | Norsk Hydro As | Substrates having bound polysaccharides and bacterial nucleic acids |
IL135148A0 (en) * | 1997-10-03 | 2001-05-20 | Galenica Pharmaceuticals Inc | A polysaccharide conjugate and pharmaceutical compositions containing the same |
AU760669B2 (en) | 1998-04-28 | 2003-05-22 | Galenica Pharmaceuticals, Inc. | Polysaccharide-antigen conjugates |
FR2781673B1 (en) * | 1998-07-28 | 2001-09-28 | Univ Picardie | USE OF A GLUCURONANE AS AN IMMUNOSTIMULATING AGENT, METHOD OF PREPARATION |
KR100501584B1 (en) * | 2000-02-03 | 2005-07-18 | (주)케이비피 | Process for preparing low molecular polymannuronate, a novel use thereof as controller of serum lipids, and functional foods and health-aid foods comprising the same |
NO320671B1 (en) * | 2001-11-30 | 2006-01-16 | Fmc Biopolymer As | Method of stimulating weight gain in fish. |
NO326145B1 (en) * | 2001-11-30 | 2008-10-06 | Fmc Biopolymer As | Method of stimulating weight gain in mammals, birds and reptiles. |
WO2005122739A2 (en) * | 2004-06-15 | 2005-12-29 | The New York Blood Center, Inc. | Adjuvancy and immune potentiating properties of natural products of onchocerca volvulus |
CA2581330A1 (en) * | 2004-09-21 | 2006-03-30 | The Brigham And Women's Hospital, Inc. | Methods and compositions relating to mannuronic acid specific binding peptides |
WO2007069468A1 (en) * | 2005-12-14 | 2007-06-21 | Nagasaki University | Cytokine secretion promoter |
JP5109266B2 (en) * | 2006-03-01 | 2012-12-26 | 凸版印刷株式会社 | Antibacterial antifungal agent |
CN104189908B (en) | 2007-11-27 | 2017-01-11 | 阿尔吉法玛公司 | Product comprising alginate oligomer, product comprising abiotic surface and composition for disinfection and cleaning |
JP5202764B2 (en) | 2009-06-03 | 2013-06-05 | アルギファルマ エーエス | Alginate oligomers used to overcome multidrug resistance in bacteria |
GB0909529D0 (en) | 2009-06-03 | 2009-07-15 | Algipharma Ipr As | Alginate oligomers for the inhibition of microbial adherence to surfaces |
GB0909557D0 (en) | 2009-06-03 | 2009-07-15 | Algipharma Ipr As | Anti-microbial alginate oligomers |
GB201116010D0 (en) | 2011-09-15 | 2011-10-26 | Algipharma As | Use of alginate oligomers to enhance the effects of antifungal agents |
GB201504878D0 (en) | 2015-03-23 | 2015-05-06 | Algipharma As | Use of alginate oligomers and CFTR modulators in the treatment of conditions associated with CFTR dysfuntion |
GB201517639D0 (en) | 2015-10-06 | 2015-11-18 | Algipharma As | Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU430857A1 (en) * | 1970-05-18 | 1974-06-05 | Харьковский научно исследовательский институт общей , неотложной хирургии , Харьковский нау исследовательский химико фармацевтический институт | Blood Circulatory Drug |
US4605623A (en) * | 1982-11-08 | 1986-08-12 | Malette William Graham | Method of altering growth and development and suppressing contamination microorganisms in cell or tissue culture |
US4578458A (en) * | 1983-03-23 | 1986-03-25 | Brigham And Women's Hospital | Mucoid exopolysaccharide vaccine against Pseudomonas aeruginosa |
JPS6164701A (en) * | 1984-09-06 | 1986-04-03 | Meito Sangyo Kk | Cationized dextran derivative/polyuronic acid polyelectrolyte complex and its use |
EP0240098A3 (en) * | 1986-04-04 | 1989-05-10 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Oligo and polysaccharides for the treatment of diseases caused by retroviruses |
JP2527317B2 (en) * | 1986-12-19 | 1996-08-21 | ライオン株式会社 | Bone disease treatment |
US4965271A (en) * | 1986-12-31 | 1990-10-23 | Hoechst Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
US4963354A (en) * | 1987-01-21 | 1990-10-16 | Genentech, Inc. | Use of tumor necrosis factor (TNF) as an adjuvant |
US5002759A (en) * | 1989-07-25 | 1991-03-26 | Colgate-Palmolive Company | Oligosaccharide inhibition of Streptococcus pyogenes adhesion |
-
1991
- 1991-03-27 US US07/676,103 patent/US5169840A/en not_active Expired - Lifetime
-
1992
- 1992-03-24 AT AT92302499T patent/ATE147984T1/en active
- 1992-03-24 DE DE69216888T patent/DE69216888T2/en not_active Expired - Lifetime
- 1992-03-24 DK DK92302499.6T patent/DK0506326T3/en active
- 1992-03-24 EP EP92302499A patent/EP0506326B1/en not_active Expired - Lifetime
- 1992-03-27 JP JP07171692A patent/JP3523654B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0506326B1 (en) | 1997-01-22 |
DE69216888D1 (en) | 1997-03-06 |
ATE147984T1 (en) | 1997-02-15 |
JPH0687751A (en) | 1994-03-29 |
DK0506326T3 (en) | 1997-07-14 |
US5169840A (en) | 1992-12-08 |
EP0506326A3 (en) | 1992-12-30 |
EP0506326A2 (en) | 1992-09-30 |
JP3523654B2 (en) | 2004-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |