DE69215983D1 - Method for measuring the concentration of an immunoreactant using electrochemiluminescence - Google Patents

Method for measuring the concentration of an immunoreactant using electrochemiluminescence

Info

Publication number
DE69215983D1
DE69215983D1 DE69215983T DE69215983T DE69215983D1 DE 69215983 D1 DE69215983 D1 DE 69215983D1 DE 69215983 T DE69215983 T DE 69215983T DE 69215983 T DE69215983 T DE 69215983T DE 69215983 D1 DE69215983 D1 DE 69215983D1
Authority
DE
Germany
Prior art keywords
immunoreactant
electrochemiluminescence
concentration
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69215983T
Other languages
German (de)
Other versions
DE69215983T2 (en
Inventor
Akira Shibue
Masaru Tanaka
Shinji Kamiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TDK Corp
Original Assignee
TDK Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP19580791A external-priority patent/JPH0518970A/en
Priority claimed from JP19580891A external-priority patent/JPH0518971A/en
Application filed by TDK Corp filed Critical TDK Corp
Publication of DE69215983D1 publication Critical patent/DE69215983D1/en
Application granted granted Critical
Publication of DE69215983T2 publication Critical patent/DE69215983T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE1992615983 1991-07-10 1992-03-11 Method for measuring the concentration of an immunoreactant using electrochemiluminescence Expired - Fee Related DE69215983T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19580791A JPH0518970A (en) 1991-07-10 1991-07-10 Antigen/antibody measuring method utilizing chemiluminescence
JP19580891A JPH0518971A (en) 1991-07-10 1991-07-10 Antigen/antibody measuring method utilizing chemiluminescence

Publications (2)

Publication Number Publication Date
DE69215983D1 true DE69215983D1 (en) 1997-01-30
DE69215983T2 DE69215983T2 (en) 1997-05-22

Family

ID=26509364

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1992615983 Expired - Fee Related DE69215983T2 (en) 1991-07-10 1992-03-11 Method for measuring the concentration of an immunoreactant using electrochemiluminescence

Country Status (2)

Country Link
EP (1) EP0522677B1 (en)
DE (1) DE69215983T2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
BR9607193B1 (en) * 1995-03-10 2009-01-13 multispecific multispecific electrochemical test.
US6319670B1 (en) * 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
FI970593A (en) * 1997-02-12 1998-08-13 Sakari Mikael Kulmala Use of coated conductors for analytical purposes
GB9809160D0 (en) * 1998-04-29 1998-07-01 Queen Mary & Westfield College Assay
US7186568B1 (en) * 2000-06-26 2007-03-06 Lumigen Inc. Electrochemiluminescence from acridan compounds
EP1322670B1 (en) * 2000-06-26 2005-12-21 Lumigen, Inc. Electrochemiluminescence from acridan compounds
US6703210B2 (en) * 2000-11-02 2004-03-09 Satake Corporation Method and device for determining concentration of dioxins
DE60236732D1 (en) * 2001-07-30 2010-07-29 Meso Scale Technologies Llc ASSAY ELECTRODES WITH REAL-ESTABLISHED LIPID / PROTEIN LAYERS AND PROCESS FOR THEIR PREPARATION AND USE
CN101038255B (en) * 2007-04-06 2010-05-19 福州大学 Capillary electrophoresis chemiluminescence detector of acridiniumester, acridine sulfonamide and marker thereof, and method thereof
WO2012028167A2 (en) * 2010-05-20 2012-03-08 Innohyphen Bv Acridinium ester chemiluminescence upon reductive triggering
JP6010110B2 (en) 2011-04-20 2016-10-19 アクセス メディカル システムズ，リミティド Repeated amplification of light-emitting polymers.
CN105717098B (en) * 2016-02-25 2018-03-27 济南大学 A kind of preparation method and application of the electrogenerated chemiluminescence bisphenol-A biology sensor based on nitrogen-doped titanium dioxide nanometer sheet
CN106248658B (en) * 2016-09-08 2018-11-13 济南大学 The preparation of paper substrate electrochemical luminescence converter and the application in carcinomebryonic antigen detection
CN109696461B (en) * 2017-10-24 2023-05-26 上海药明生物技术有限公司 Release detection method of therapeutic antibody
WO2019079970A1 (en) * 2017-10-24 2019-05-02 上海药明生物技术有限公司 Release detection method for therapeutic antibody

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352791A (en) * 1965-01-22 1967-11-14 American Cyanamid Co Generation of light by the reaction of peroxide with heterocyclic derivatives
FR2043486B1 (en) * 1969-05-28 1973-07-13 Roussel Uclaf
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
EP0082636B2 (en) * 1981-12-11 2006-10-18 The Welsh National School of Medicine Luminescent labelling materials and procedures
ATE111083T1 (en) * 1986-10-22 1994-09-15 Abbott Lab CHEMILUMINESCENT ACRIDINIUM AND PHENANTRIDINIUM SALTS.
DE3844954C2 (en) * 1988-02-20 1998-07-16 Hoechst Ag Special chemiluminescent acridine derivatives and their use in luminescent immunoassays
CA1325527C (en) * 1988-04-28 1993-12-28 Nicholas Leventis Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5068088A (en) * 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
GB2233450B (en) * 1989-06-24 1993-06-30 Univ Wales Medicine Detecting or quantifing multiple analytes with luminescent reagents

Also Published As

Publication number Publication date
EP0522677A1 (en) 1993-01-13
EP0522677B1 (en) 1996-12-18
DE69215983T2 (en) 1997-05-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8320 Willingness to grant licences declared (paragraph 23)
8339 Ceased/non-payment of the annual fee