DE69210231D1 - METHOD FOR CLEANING LOFEPRAMINE BY CRYSTALIZATION - Google Patents

METHOD FOR CLEANING LOFEPRAMINE BY CRYSTALIZATION

Info

Publication number
DE69210231D1
DE69210231D1 DE69210231T DE69210231T DE69210231D1 DE 69210231 D1 DE69210231 D1 DE 69210231D1 DE 69210231 T DE69210231 T DE 69210231T DE 69210231 T DE69210231 T DE 69210231T DE 69210231 D1 DE69210231 D1 DE 69210231D1
Authority
DE
Germany
Prior art keywords
crystalization
lofepramine
cleaning
cleaning lofepramine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69210231T
Other languages
German (de)
Inventor
Wilhelm Schuler
Richard Lyons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JELLALABAD Ltd
Original Assignee
JELLALABAD Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JELLALABAD Ltd filed Critical JELLALABAD Ltd
Priority to DE69210231T priority Critical patent/DE69210231D1/en
Application granted granted Critical
Publication of DE69210231D1 publication Critical patent/DE69210231D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DE69210231T 1991-03-13 1992-02-27 METHOD FOR CLEANING LOFEPRAMINE BY CRYSTALIZATION Expired - Lifetime DE69210231D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69210231T DE69210231D1 (en) 1991-03-13 1992-02-27 METHOD FOR CLEANING LOFEPRAMINE BY CRYSTALIZATION

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4108119A DE4108119A1 (en) 1991-03-13 1991-03-13 METHOD FOR PRODUCING 4'-CHLORINE-2 - ((3- (10,11-DIHYDRO-5H-DIBENZ (B, F) AZEPIN-5-YL) PROPYL) METHYLAMINNO) ACETOPHENONE AND ITS SALTS, THE STABILIZATION OF ITS SALTS, HERBY AVAILABLE PRODUCTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE69210231T DE69210231D1 (en) 1991-03-13 1992-02-27 METHOD FOR CLEANING LOFEPRAMINE BY CRYSTALIZATION
PCT/EP1992/000428 WO1992019599A1 (en) 1991-03-13 1992-02-27 Process for the purification of lofepramine by crystallisation

Publications (1)

Publication Number Publication Date
DE69210231D1 true DE69210231D1 (en) 1996-05-30

Family

ID=6427192

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4108119A Withdrawn DE4108119A1 (en) 1991-03-13 1991-03-13 METHOD FOR PRODUCING 4'-CHLORINE-2 - ((3- (10,11-DIHYDRO-5H-DIBENZ (B, F) AZEPIN-5-YL) PROPYL) METHYLAMINNO) ACETOPHENONE AND ITS SALTS, THE STABILIZATION OF ITS SALTS, HERBY AVAILABLE PRODUCTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE69210231T Expired - Lifetime DE69210231D1 (en) 1991-03-13 1992-02-27 METHOD FOR CLEANING LOFEPRAMINE BY CRYSTALIZATION

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4108119A Withdrawn DE4108119A1 (en) 1991-03-13 1991-03-13 METHOD FOR PRODUCING 4'-CHLORINE-2 - ((3- (10,11-DIHYDRO-5H-DIBENZ (B, F) AZEPIN-5-YL) PROPYL) METHYLAMINNO) ACETOPHENONE AND ITS SALTS, THE STABILIZATION OF ITS SALTS, HERBY AVAILABLE PRODUCTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Country Status (4)

Country Link
EP (1) EP0575370B1 (en)
DE (2) DE4108119A1 (en)
IE (1) IE920804A1 (en)
WO (1) WO1992019599A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008139484A2 (en) * 2007-05-16 2008-11-20 R. L. Fine Chem New process for the synthesis of loferpramine maleate: a stable salt of loferpramine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1177525A (en) * 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest
GB1497306A (en) * 1975-07-03 1978-01-05 Leo Ab Preparation of lofepramine and its hydrochloride
GB1498857A (en) * 1975-07-03 1978-01-25 Leo Ab Antidepressant composition

Also Published As

Publication number Publication date
EP0575370B1 (en) 1996-04-24
WO1992019599A1 (en) 1992-11-12
EP0575370A1 (en) 1993-12-29
IE920804A1 (en) 1992-09-23
DE4108119A1 (en) 1992-09-17

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Legal Events

Date Code Title Description
8332 No legal effect for de