DE69132167T2 - CONDENSED BENZOXA RING CONNECTION, THEIR PRODUCTION AND THIS MEDICINAL PRODUCT - Google Patents

CONDENSED BENZOXA RING CONNECTION, THEIR PRODUCTION AND THIS MEDICINAL PRODUCT

Info

Publication number
DE69132167T2
DE69132167T2 DE69132167T DE69132167T DE69132167T2 DE 69132167 T2 DE69132167 T2 DE 69132167T2 DE 69132167 T DE69132167 T DE 69132167T DE 69132167 T DE69132167 T DE 69132167T DE 69132167 T2 DE69132167 T2 DE 69132167T2
Authority
DE
Germany
Prior art keywords
benzoxa
condensed
production
medicinal product
ring connection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132167T
Other languages
German (de)
Other versions
DE69132167D1 (en
Inventor
Tatsuki Shiota
Takumi Takeyasu
Kenichiro Kataoka
Tsutomu Mochizuki
Hirofumi Tanabe
Mikio Ota
Masatoshi Kano
Hisao Yamaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DE69132167D1 publication Critical patent/DE69132167D1/en
Publication of DE69132167T2 publication Critical patent/DE69132167T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

A benzoxazole compound and a 2,3-dihydrobenzofuran compound, each represented by general formula (I), and a pharmaceutical composition containing a pharmaceutically acceptable salt thereof, which is used for inhibiting ATCAT and treating hyperlipemia and arteriosclerosis, wherein one member among P, Q, R and S represents a group of (a), and R1, R2 and the rest of P to S represent various substituents. <CHEM>
DE69132167T 1990-12-28 1991-12-27 CONDENSED BENZOXA RING CONNECTION, THEIR PRODUCTION AND THIS MEDICINAL PRODUCT Expired - Fee Related DE69132167T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP41544390 1990-12-28
JP2914391 1991-01-31
PCT/JP1991/001793 WO1992012144A1 (en) 1990-12-28 1991-12-27 Condensed benzoxa ring compound, production thereof, and pharmaceutical composition containing the same

Publications (2)

Publication Number Publication Date
DE69132167D1 DE69132167D1 (en) 2000-06-08
DE69132167T2 true DE69132167T2 (en) 2000-12-14

Family

ID=26367294

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132167T Expired - Fee Related DE69132167T2 (en) 1990-12-28 1991-12-27 CONDENSED BENZOXA RING CONNECTION, THEIR PRODUCTION AND THIS MEDICINAL PRODUCT

Country Status (11)

Country Link
US (1) US5496853A (en)
EP (1) EP0632031B1 (en)
JP (1) JP3095413B2 (en)
KR (1) KR930703281A (en)
AT (1) ATE192446T1 (en)
AU (1) AU652981B2 (en)
CA (1) CA2098912A1 (en)
DE (1) DE69132167T2 (en)
ES (1) ES2145743T3 (en)
HU (1) HUT68721A (en)
WO (1) WO1992012144A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2098912A1 (en) * 1990-12-28 1992-06-29 Tatsuki Shiota Benzoxa condensed ring compound, process for producing the same and pharmaceutical composition comprising the same
US5451596A (en) * 1992-12-29 1995-09-19 Rhone Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US6372770B1 (en) 1994-10-12 2002-04-16 Euro-Celtique, S.A. Benzoxazoles
US5665737B1 (en) * 1994-10-12 1999-02-16 Euro Celtique Sa Substituted benzoxazoles
JPH10508032A (en) * 1994-12-13 1998-08-04 ユーロ−セルティーク，エス．エイ． Arylthioxanthines
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
EP0799040B1 (en) 1994-12-13 2003-08-20 Euroceltique S.A. Trisubstituted thioxanthines
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
US5684041A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
KR100215541B1 (en) * 1996-04-19 1999-08-16 박원훈 Benzoxazole nonlinear optical derivatives and polymers obtained from them
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5744473A (en) * 1996-09-16 1998-04-28 Euro-Celtique, S.A. PDE IV inhibitors: "bis-compounds"
CN1297550C (en) * 1998-12-04 2007-01-31 武田药品工业株式会社 Benzofuran derivatives, process for the preparation of the same and uses thereof
ES2420932T3 (en) * 2003-06-26 2013-08-27 Takeda Pharmaceutical Company Limited Cannabinoid receptor modulator
TWI652014B (en) * 2013-09-13 2019-03-01 美商艾佛艾姆希公司 Heterocyclic substituted bicycloazole insecticide
US20180368404A1 (en) * 2014-11-06 2018-12-27 Basf Se 3-pyridyl heterobicyclic compound for controlling invertebrate pests
KR101667878B1 (en) * 2015-04-14 2016-10-19 문종섭 A appratus and the method for Osseo-Integrated Dental Implant stability

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
US3634462A (en) * 1968-06-26 1972-01-11 Fmc Corp 2 3-dihydro-2 2-dimethyl-7-aceto acetamidobenzofuran
JPS6031208B2 (en) * 1974-07-10 1985-07-20 帝人株式会社 polyamide solution
US4297349A (en) * 1980-04-15 1981-10-27 Sandoz, Inc. Silicon-bearing carboxylic acids and amides
US4296240A (en) * 1980-04-24 1981-10-20 Sandoz, Inc. Silacycloalkane amides
DE3008812A1 (en) * 1980-03-07 1981-09-24 Hoechst Ag, 6000 Frankfurt MIXTURES OF OPTICAL BRIGHTENERS
US4649149A (en) * 1980-05-22 1987-03-10 Ciba-Geigy Corporation Process for the manufacture of novel benzazole derivatives, pharmaceutical preparations containing these derivatives, and their use
MA19290A1 (en) * 1980-05-22 1982-04-01 Ciba Geigy Ag BENZOLE DERIVATIVES, THEIR PREPARATON AND THEIR THERAPEUTIC USES.
JPS60215680A (en) * 1984-04-10 1985-10-29 Mitsubishi Chem Ind Ltd N-2,3-dihydrobenzofuranyl benzamide derivative and agricultural and horticultural fungicide containing said derivative as active component
CA1261835A (en) * 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
GB2169283A (en) * 1985-01-02 1986-07-09 Sumitomo Chemical Co Fungicidal aniline derivatives
JPS61233742A (en) * 1985-04-09 1986-10-18 Konishiroku Photo Ind Co Ltd Silver halide photographic sensitive material
JPH075532B2 (en) * 1985-06-04 1995-01-25 住友化学工業株式会社 Benzanilide derivative and fungicide containing it as an active ingredient
US5002691A (en) * 1986-11-06 1991-03-26 The Clorox Company Oxidant detergent containing stable bleach activator granules
JPH0193569A (en) * 1987-07-02 1989-04-12 Warner Lambert Co N-((2,6-disubstituted)phenyl)urea and carbamate inhibitor of acyl coa-cholesterol acyltransferase
US4847257A (en) * 1987-08-20 1989-07-11 Merck & Co., Inc. 5-Amino or substituted amino 1,2,3,-triazoles useful as antiproliferative agents
DE3740985A1 (en) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh USE OF LINEAR FURNISHED TRICYCLES AS AN INHIBITORS OF THE ERYTHROCYTE AGGREGATION
DE3809868A1 (en) * 1988-03-24 1989-10-05 Boehringer Mannheim Gmbh NEW HETEROCYCLICALLY SUBSTITUTED 5,7-DIHYDRO-PYRROLO (3,2-F) BENZOXAZOL-6-ONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5246927A (en) * 1988-08-17 1993-09-21 Ciba-Geigy Corporation Benzazole derivatives, processes for their preparation containing such compounds and the use thereof
IE68675B1 (en) * 1990-11-01 1996-07-10 Takeda Chemical Industries Ltd Aminocoumaran derivatives their production and use
US5214206A (en) * 1990-11-07 1993-05-25 Warner-Lambert Company Aminosulfonyl urea acat inhibitors
CA2098912A1 (en) * 1990-12-28 1992-06-29 Tatsuki Shiota Benzoxa condensed ring compound, process for producing the same and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
AU652981B2 (en) 1994-09-15
ATE192446T1 (en) 2000-05-15
AU9110591A (en) 1992-08-17
EP0632031B1 (en) 2000-05-03
HUT68721A (en) 1995-07-28
HU9301866D0 (en) 1993-12-28
CA2098912A1 (en) 1992-06-29
JP3095413B2 (en) 2000-10-03
ES2145743T3 (en) 2000-07-16
EP0632031A1 (en) 1995-01-04
EP0632031A4 (en) 1995-02-08
DE69132167D1 (en) 2000-06-08
KR930703281A (en) 1993-11-29
WO1992012144A1 (en) 1992-07-23
US5496853A (en) 1996-03-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee