DE69112634D1 - IMMUNOGENOUS COMPLEXES, IN PARTICULAR ISCOMS. - Google Patents
IMMUNOGENOUS COMPLEXES, IN PARTICULAR ISCOMS.Info
- Publication number
- DE69112634D1 DE69112634D1 DE69112634T DE69112634T DE69112634D1 DE 69112634 D1 DE69112634 D1 DE 69112634D1 DE 69112634 T DE69112634 T DE 69112634T DE 69112634 T DE69112634 T DE 69112634T DE 69112634 D1 DE69112634 D1 DE 69112634D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- iscoms
- quil
- fractions
- complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002163 immunogen Effects 0.000 abstract 5
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 abstract 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 abstract 3
- 229930182490 saponin Natural products 0.000 abstract 3
- 150000007949 saponins Chemical class 0.000 abstract 3
- 229930182558 Sterol Natural products 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003432 sterols Chemical class 0.000 abstract 1
- 235000003702 sterols Nutrition 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PCT No. PCT/NL91/00211 Sec. 371 Date Apr. 19, 1993 Sec. 102(e) Date Apr. 19, 1993 PCT Filed Oct. 23, 1991 PCT Pub. No. WO92/06710 PCT Pub. Date Apr. 30, 1992The invention relates to immunogenic complexes such as two-dimensional lamellae having a honeycomb structure and in particular three-dimensional iscoms, which immunogenic complexes are composed of at least one sterol, one saponin and, in the case of iscoms, also a phospholipid and also, optionally, at least one antigen generating an immune reaction. The saponin used is at least one of the fractions which are derived from Quil A by means of hydrophobic interaction chromatography and have the designations QA 1 to QA 23, as is shown in the figure by the numerals 1 to 23. Preferably, the saponin used is one or more of the fractions derived from Quil A having the designations QA 3, QA 17 and QA 23. As well as relating to the immunogenic complex, the invention also relates to the specific method of preparation of the relevant Quil A fractions, to vaccines which contain such immunogenic complexes and to kits which contain, on the one hand, an (empty) immunogenic complex and, on the other hand, one or more antigenic proteins or peptides having a hydrophobic fragment which may or may not have been synthetically introduced.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9002314A NL9002314A (en) | 1990-10-23 | 1990-10-23 | IMMUNOGENE COMPLEXES, IN PARTICULAR ISCOMS. |
| PCT/NL1991/000211 WO1992006710A1 (en) | 1990-10-23 | 1991-10-23 | Immunogenic complexes, in particular iscoms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69112634D1 true DE69112634D1 (en) | 1995-10-05 |
| DE69112634T2 DE69112634T2 (en) | 1996-02-08 |
Family
ID=19857870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69112634T Expired - Lifetime DE69112634T2 (en) | 1990-10-23 | 1991-10-23 | IMMUNOGENOUS COMPLEXES, IN PARTICULAR ISCOMS. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5620690A (en) |
| EP (1) | EP0555276B1 (en) |
| AT (1) | ATE127024T1 (en) |
| CA (1) | CA2094600C (en) |
| DE (1) | DE69112634T2 (en) |
| DK (1) | DK0555276T3 (en) |
| ES (1) | ES2075964T3 (en) |
| GR (1) | GR3017778T3 (en) |
| NL (1) | NL9002314A (en) |
| WO (1) | WO1992006710A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716848A (en) * | 1992-10-30 | 1998-02-10 | Seed Capital Investment (Sci) B.V. | Cultured cells of quillaja sp |
| NL9301690A (en) * | 1993-08-12 | 1995-04-18 | Seed Capital Investments | Compounds with adjuvant activity. |
| WO1995009179A1 (en) * | 1993-09-30 | 1995-04-06 | Seed Capital Investments (Sci) B.V. | Compounds with adjuvant activity |
| AUPM500494A0 (en) * | 1994-04-12 | 1994-05-05 | Minister For Agriculture & Rural Affairs For The State Of New South Wales, The | Composition for use in increasing mucosal immunity |
| AUPM873294A0 (en) * | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| UA56132C2 (en) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Vaccine composition (variants), method for stabilizing qs21 providing resistance against hydrolysis (variants), method for manufacturing vaccine |
| GB9620795D0 (en) * | 1996-10-05 | 1996-11-20 | Smithkline Beecham Plc | Vaccines |
| SE9600648D0 (en) * | 1996-02-21 | 1996-02-21 | Bror Morein | Receptor binding unit |
| AUPO517897A0 (en) * | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| ES2327693T3 (en) * | 1997-08-29 | 2009-11-02 | Antigenics Inc. | COMPOSITIONS THAT INCLUDE THE QS-21 ADJUSTER AND EXCIPIENT POLYSORBATE OR CYCLODEXTRINE. |
| GB9817052D0 (en) * | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| US7713942B2 (en) | 2001-04-04 | 2010-05-11 | Nordic Vaccine Technology A/S | Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides |
| JP2004528321A (en) | 2001-04-04 | 2004-09-16 | ノルディック ワクチン テクノロジー アクティーゼルスカブ | Polynucleotide binding complexes containing sterols and saponins |
| SE0202110D0 (en) * | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| EP1545605B8 (en) * | 2002-10-02 | 2010-05-26 | Nordic Vaccine A/S | Composition for vaccination |
| SE0300795D0 (en) | 2003-03-24 | 2003-03-24 | Isconova Ab | Composition comprising iscom particles and live micro-organisms |
| SE0301998D0 (en) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| ES2433467T3 (en) * | 2005-01-20 | 2013-12-11 | Isconova Ab | Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide |
| EP1873522B1 (en) * | 2005-04-14 | 2014-08-13 | Panasonic Healthcare Co., Ltd. | Method for determination of hemoglobin derivative, and reagent composition, assay kit, analysis device and analysis system for use in the method |
| KR20110117654A (en) | 2009-01-13 | 2011-10-27 | 트랜스진 에스.에이. | Use of a saccharomyces cerevisiae mitochondrial nucleic acids fraction for immune stimulation |
| AU2012319239B2 (en) * | 2011-10-03 | 2017-04-20 | Mx Adjuvac Ab | Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds |
| CN114699519A (en) | 2015-09-03 | 2022-07-05 | 诺瓦瓦克斯股份有限公司 | Vaccine compositions with improved stability and immunogenicity |
| EP3658118A4 (en) | 2017-07-24 | 2021-03-31 | Novavax, Inc. | Methods and compositions for treating respiratory disease |
| EP3768308A4 (en) | 2018-03-19 | 2022-01-26 | Novavax, Inc. | Multivalent influenza nanoparticle vaccines |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (en) * | 1982-10-18 | 1982-10-18 | Bror Morein | IMMUNOGENT MEMBRANE PROTEIN COMPLEX, SET FOR PREPARATION AND USE THEREOF |
| SE8405493D0 (en) * | 1984-11-01 | 1984-11-01 | Bror Morein | IMMUNOGENT COMPLEX AND KITCHEN FOR PREPARING IT AND USING IT AS IMMUNOSTIMENTING AGENTS |
| ATE71303T1 (en) * | 1986-01-14 | 1992-01-15 | Nederlanden Staat | PROCESS FOR THE PREPARATION OF IMMUNOLOGICAL COMPLEXES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM. |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| CA1331443C (en) * | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| US4981684A (en) * | 1989-10-24 | 1991-01-01 | Coopers Animal Health Limited | Formation of adjuvant complexes |
| US5273965A (en) * | 1992-07-02 | 1993-12-28 | Cambridge Biotech Corporation | Methods for enhancing drug delivery with modified saponins |
-
1990
- 1990-10-23 NL NL9002314A patent/NL9002314A/en not_active Application Discontinuation
-
1991
- 1991-10-23 ES ES91918619T patent/ES2075964T3/en not_active Expired - Lifetime
- 1991-10-23 AT AT91918619T patent/ATE127024T1/en not_active IP Right Cessation
- 1991-10-23 DE DE69112634T patent/DE69112634T2/en not_active Expired - Lifetime
- 1991-10-23 DK DK91918619.7T patent/DK0555276T3/en active
- 1991-10-23 EP EP91918619A patent/EP0555276B1/en not_active Expired - Lifetime
- 1991-10-23 WO PCT/NL1991/000211 patent/WO1992006710A1/en active IP Right Grant
- 1991-10-23 CA CA002094600A patent/CA2094600C/en not_active Expired - Lifetime
- 1991-10-23 US US08/039,294 patent/US5620690A/en not_active Expired - Lifetime
-
1995
- 1995-10-18 GR GR950402880T patent/GR3017778T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5620690A (en) | 1997-04-15 |
| EP0555276B1 (en) | 1995-08-30 |
| EP0555276A1 (en) | 1993-08-18 |
| CA2094600C (en) | 1998-12-08 |
| WO1992006710A1 (en) | 1992-04-30 |
| DE69112634T2 (en) | 1996-02-08 |
| CA2094600A1 (en) | 1992-04-24 |
| GR3017778T3 (en) | 1996-01-31 |
| DK0555276T3 (en) | 1995-09-18 |
| NL9002314A (en) | 1992-05-18 |
| ATE127024T1 (en) | 1995-09-15 |
| ES2075964T3 (en) | 1995-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |