DE69103230T2 - 1-pyridylimidazole derivative and process for its manufacture and use. - Google Patents
1-pyridylimidazole derivative and process for its manufacture and use.Info
- Publication number
- DE69103230T2 DE69103230T2 DE69103230T DE69103230T DE69103230T2 DE 69103230 T2 DE69103230 T2 DE 69103230T2 DE 69103230 T DE69103230 T DE 69103230T DE 69103230 T DE69103230 T DE 69103230T DE 69103230 T2 DE69103230 T2 DE 69103230T2
- Authority
- DE
- Germany
- Prior art keywords
- manufacture
- pyridylimidazole derivative
- pyridylimidazole
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- MIJZSNMJNBVCEB-UHFFFAOYSA-N 2-imidazol-1-ylpyridine Chemical class C1=NC=CN1C1=CC=CC=N1 MIJZSNMJNBVCEB-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17313590 | 1990-06-29 | ||
| JP23543990 | 1990-09-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69103230D1 DE69103230D1 (en) | 1994-09-08 |
| DE69103230T2 true DE69103230T2 (en) | 1994-12-01 |
Family
ID=26495230
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69103231T Expired - Fee Related DE69103231T2 (en) | 1990-06-29 | 1991-02-19 | 1-phenylimidazole derivatives, their production process and application. |
| DE69103230T Expired - Fee Related DE69103230T2 (en) | 1990-06-29 | 1991-02-19 | 1-pyridylimidazole derivative and process for its manufacture and use. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69103231T Expired - Fee Related DE69103231T2 (en) | 1990-06-29 | 1991-02-19 | 1-phenylimidazole derivatives, their production process and application. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5153215A (en) |
| EP (2) | EP0464979B1 (en) |
| KR (2) | KR920000745A (en) |
| AU (2) | AU633183B2 (en) |
| BR (2) | BR9100662A (en) |
| CA (2) | CA2036147A1 (en) |
| CZ (2) | CZ279634B6 (en) |
| DE (2) | DE69103231T2 (en) |
| ES (2) | ES2057755T3 (en) |
| HU (2) | HUT58058A (en) |
| IL (2) | IL97278A0 (en) |
| MY (2) | MY104627A (en) |
| SK (1) | SK278039B6 (en) |
| YU (2) | YU30491A (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY106533A (en) * | 1990-02-20 | 1995-06-30 | Sumitomo Chemical Co | A 4-tert.-butyl imidazole derivative and its production and use. |
| CA2036147A1 (en) * | 1990-06-29 | 1991-12-30 | Hiroki Tomioka | A 1-pyridylimidazole derivative and its production and use |
| US5252590A (en) * | 1991-06-28 | 1993-10-12 | Sumitomo Chemical Company, Limited | 1-pyridylimidazole derivative |
| EP0599183A1 (en) * | 1992-11-25 | 1994-06-01 | Rhone-Poulenc Agrochimie | Manufacturing of pesticides and intermediates |
| JP3715994B2 (en) * | 1993-12-21 | 2005-11-16 | 住友化学株式会社 | Pest control agent |
| US6413542B1 (en) | 1996-03-29 | 2002-07-02 | Merial | Direct pour-on antiparasitic skin solution and methods for treating, preventing and controlling myasis |
| ES2359973T3 (en) * | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | LIQUID POLYMER COMPOSITIONS FOR THE CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES. |
| US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
| US20040077703A1 (en) * | 2002-10-02 | 2004-04-22 | Soll Mark D. | Nodulisporic acid derivative spot-on formulations for combating parasites |
| US7262214B2 (en) | 2003-02-26 | 2007-08-28 | Merial Limited | 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases |
| US7531186B2 (en) | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| US20050234119A1 (en) * | 2004-04-16 | 2005-10-20 | Soll Mark D | Antiparasitical agents and methods for treating, preventing and controlling external parasites in animals |
| US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
| NZ573758A (en) * | 2006-07-05 | 2012-01-12 | Aventis Agriculture | 1-Phenyl-3-cyano-pyrazole derivatives and pesticidal formulations containing them |
| ES2614931T3 (en) * | 2006-08-04 | 2017-06-02 | Beth Israel Deaconess Medical Center | Pyruvate kinase inhibitors and disease treatment methods |
| KR101660068B1 (en) | 2008-11-19 | 2016-09-26 | 메리얼 인코포레이티드 | Compositions comprising 1-arylpyrazole alone or in combination with formamidine for the treatment of parasitic infection |
| US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
| JP5756457B2 (en) * | 2009-04-06 | 2015-07-29 | アジオス ファーマシューティカルズ， インコーポレイテッド | Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use |
| ES2619557T3 (en) | 2009-05-04 | 2017-06-26 | Agios Pharmaceuticals, Inc. | PKM2 activators for use in cancer treatment |
| ES2618630T3 (en) | 2009-06-29 | 2017-06-21 | Agios Pharmaceuticals, Inc. | Therapeutic compositions and related methods of use |
| PT2448582T (en) | 2009-06-29 | 2017-07-10 | Agios Pharmaceuticals Inc | Quinoline-8-sulfonamide derivatives having an anticancer activity |
| AU2010330844B2 (en) | 2009-12-17 | 2014-11-27 | Boehringer Ingelheim Animal Health USA Inc. | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
| UA108641C2 (en) | 2010-04-02 | 2015-05-25 | PARASITICID COMPOSITION CONTAINING FOUR ACTIVE AGENTS AND METHOD OF APPLICATION | |
| ES2564952T3 (en) | 2010-12-17 | 2016-03-30 | Agios Pharmaceuticals, Inc. | New derivatives of N- (4- (azetidine-1-carbonyl) phenyl) - (hetero-) arylsulfonamide as modulators of pyruvate kinase M2 (PKM2) |
| EP2655350B1 (en) | 2010-12-21 | 2016-03-09 | Agios Pharmaceuticals, Inc. | Bicyclic pkm2 activators |
| TWI549947B (en) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | Therapeutic compounds and compositions |
| WO2012151440A1 (en) | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| MX367387B (en) | 2011-05-03 | 2019-08-19 | Agios Pharmaceuticals Inc | Pyruvate kinase activators for use in therapy. |
| AU2012340351B2 (en) | 2011-11-17 | 2017-06-15 | Boehringer Ingelheim Animal Health USA Inc. | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof |
| JO3626B1 (en) | 2012-02-23 | 2020-08-27 | Merial Inc | Topical compositions comprising fipronil and permethrin and methods of use |
| TWI579274B (en) | 2012-04-20 | 2017-04-21 | 龍馬躍公司 | Improved processes for the preparation of 1-aryl-5-alkyl pyrazole compounds |
| WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| AU2015339096B2 (en) | 2014-10-31 | 2018-08-02 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal composition comprising fipronil |
| EP4344703A1 (en) | 2015-06-11 | 2024-04-03 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996366A (en) * | 1973-11-19 | 1976-12-07 | The Boots Company Limited | Thio derivatives of imidazol-1-yl carboxamides |
| GB1408877A (en) * | 1971-12-07 | 1975-10-08 | Boots Co Ltd | Substituted imidazoles and their use as pesticides |
| US3940484A (en) * | 1971-12-07 | 1976-02-24 | The Boots Company Limited | Insecticidal compositions and methods of combatting insects using substituted imidazoles |
| US4048188A (en) * | 1971-12-07 | 1977-09-13 | The Boots Company Limited | 1-Carbonamido imidazoles |
| GB2044754B (en) * | 1978-11-14 | 1983-05-05 | Eisai Co Ltd | Imidazoles |
| US4600430A (en) * | 1985-02-22 | 1986-07-15 | Eli Lilly And Company | Pyridinylimidazolidinone compounds |
| US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
| DE3614364A1 (en) * | 1986-04-28 | 1987-10-29 | Hoechst Ag | 1-PHENYL IMIDAZOLE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS GROWTH REGULATORS |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| FI91754C (en) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | An analogous method for preparing an imidazole derivative useful as a medicament |
| DE3811574A1 (en) * | 1988-03-31 | 1989-10-19 | Schering Ag | N-SUBSTITUTED IMIDAZOLES, METHODS FOR THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS |
| SK279264B6 (en) * | 1989-05-05 | 1998-08-05 | Rhone-Poulenc Agrochimie | 1-arylimidazoles, method of preparation thereof, use and agent containing 1-arylimidazoles |
| MY106533A (en) * | 1990-02-20 | 1995-06-30 | Sumitomo Chemical Co | A 4-tert.-butyl imidazole derivative and its production and use. |
| CA2036147A1 (en) * | 1990-06-29 | 1991-12-30 | Hiroki Tomioka | A 1-pyridylimidazole derivative and its production and use |
-
1991
- 1991-02-12 CA CA002036147A patent/CA2036147A1/en not_active Abandoned
- 1991-02-12 CA CA002036148A patent/CA2036148A1/en not_active Abandoned
- 1991-02-18 MY MYPI91000254A patent/MY104627A/en unknown
- 1991-02-18 MY MYPI91000253A patent/MY104626A/en unknown
- 1991-02-18 KR KR1019910002563A patent/KR920000745A/en not_active Application Discontinuation
- 1991-02-18 KR KR1019910002564A patent/KR920000729A/en not_active Application Discontinuation
- 1991-02-19 IL IL97278A patent/IL97278A0/en unknown
- 1991-02-19 HU HU91548A patent/HUT58058A/en unknown
- 1991-02-19 EP EP91301290A patent/EP0464979B1/en not_active Expired - Lifetime
- 1991-02-19 HU HU91549A patent/HU206951B/en not_active IP Right Cessation
- 1991-02-19 ES ES91301291T patent/ES2057755T3/en not_active Expired - Lifetime
- 1991-02-19 BR BR919100662A patent/BR9100662A/en unknown
- 1991-02-19 DE DE69103231T patent/DE69103231T2/en not_active Expired - Fee Related
- 1991-02-19 DE DE69103230T patent/DE69103230T2/en not_active Expired - Fee Related
- 1991-02-19 ES ES91301290T patent/ES2057754T3/en not_active Expired - Lifetime
- 1991-02-19 EP EP91301291A patent/EP0464980B1/en not_active Expired - Lifetime
- 1991-02-19 BR BR919100663A patent/BR9100663A/en unknown
- 1991-02-19 IL IL9727991A patent/IL97279A/en not_active IP Right Cessation
- 1991-02-20 CZ CS91441A patent/CZ279634B6/en unknown
- 1991-02-20 AU AU71186/91A patent/AU633183B2/en not_active Ceased
- 1991-02-20 SK SK440-91A patent/SK278039B6/en unknown
- 1991-02-20 YU YU30491A patent/YU30491A/en unknown
- 1991-02-20 AU AU71188/91A patent/AU633184B2/en not_active Ceased
- 1991-02-20 US US07/658,326 patent/US5153215A/en not_active Expired - Fee Related
- 1991-02-20 YU YU30391A patent/YU30391A/en unknown
- 1991-02-20 CZ CS91440A patent/CZ279536B6/en unknown
- 1991-02-20 US US07/658,324 patent/US5122530A/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |