DE69031424T2 - PROTEASE INHIBITORS - Google Patents

PROTEASE INHIBITORS

Info

Publication number
DE69031424T2
DE69031424T2 DE69031424T DE69031424T DE69031424T2 DE 69031424 T2 DE69031424 T2 DE 69031424T2 DE 69031424 T DE69031424 T DE 69031424T DE 69031424 T DE69031424 T DE 69031424T DE 69031424 T2 DE69031424 T2 DE 69031424T2
Authority
DE
Germany
Prior art keywords
pct
gelin
inhibitor
chymotrypsin
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69031424T
Other languages
German (de)
Other versions
DE69031424D1 (en
Inventor
Anthony Atkinson
Wiltshire Salisbury
Asgar Electricwala
Roy Sawyer
Sa Tr Gb Dyfed
Sicard Nils Von
Wales Swansea
Gerard Voerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of DE69031424D1 publication Critical patent/DE69031424D1/en
Application granted granted Critical
Publication of DE69031424T2 publication Critical patent/DE69031424T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

PCT No. PCT/NL90/00046 Sec. 371 Date Oct. 24, 1991 Sec. 102(e) Date Oct. 24, 1991 PCT Filed Apr. 12, 1990 PCT Pub. No. WO90/12808 PCT Pub. Date Nov. 1, 1990.This invention relates to a novel protease-inhibitor,-which we called GELIN-and to pharmaceutical and cosmetic preparations thereof, containing this compound. GELIN is an inhibitor of human and porcine leucocyte elastase and chymotrypsin. GELIN has specific antibiotic properties. It also relates to the novel use of EGLIN, another chymotrypsin-inhibitor in cosmetic preparations.
DE69031424T 1989-04-14 1990-04-12 PROTEASE INHIBITORS Expired - Lifetime DE69031424T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8900943A NL8900943A (en) 1989-04-14 1989-04-14 PROTEASE INHIBITOR.
PCT/NL1990/000046 WO1990012808A1 (en) 1989-04-14 1990-04-12 Protease inhibitor

Publications (2)

Publication Number Publication Date
DE69031424D1 DE69031424D1 (en) 1997-10-16
DE69031424T2 true DE69031424T2 (en) 1998-04-09

Family

ID=19854482

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69031424T Expired - Lifetime DE69031424T2 (en) 1989-04-14 1990-04-12 PROTEASE INHIBITORS

Country Status (12)

Country Link
US (1) US5397694A (en)
EP (1) EP0466833B1 (en)
JP (1) JP3101629B2 (en)
KR (1) KR0167344B1 (en)
AT (1) ATE157989T1 (en)
AU (1) AU648252B2 (en)
CA (1) CA2053242C (en)
DE (1) DE69031424T2 (en)
DK (1) DK0466833T3 (en)
ES (1) ES2108694T3 (en)
NL (1) NL8900943A (en)
WO (1) WO1990012808A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0662514A1 (en) * 1994-01-07 1995-07-12 Ciba-Geigy Ag Hirustasin, an antistasin type serine proteinase inhibitor from Hiruda
NZ270194A (en) * 1994-01-07 1996-05-28 Ciba Geigy Ag Hirustasin, a serine protease inhibitor from hirudo medicinalis
KR0137519B1 (en) * 1995-04-27 1998-04-30 심상철 Elastase inhibitor from korean hirudo nipponia
GB2304048A (en) * 1995-08-12 1997-03-12 John William Carson Medicament containing saliva extract
KR100224383B1 (en) 1996-09-09 1999-10-15 윤덕용 Protease inhibiting peptide derived from gumerin
FR2755015B1 (en) * 1996-10-25 1998-12-24 Sod Conseils Rech Applic USE OF A FLAVONOID EXTRACT OF GINKGO BILOBA SUBSTANTIALLY FREE OF TERPENES, IN THE ORAL FIELD, AND COMPOSITION CONTAINING SUCH EXTRACT
FR2763944B1 (en) * 1997-06-03 2000-12-15 Centre Nat Rech Scient NOVEL COUMARIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS DRUGS AS PROTEASE INHIBITORS
AT406120B (en) * 1997-08-28 2000-02-25 Immuno Ag TISSUE ADHESIVE
US7063838B1 (en) * 1999-09-24 2006-06-20 Proteon Therapeutics Llc Methods for treating an artery or vein in a human subject
ATE361095T1 (en) * 1999-09-24 2007-05-15 Proteon Therapeutics Inc USING ELASTASE TO OPEN CLOGGED ARTERIES AND VEINS
US7632494B2 (en) * 1999-09-24 2009-12-15 Proteon Therapeutics, Inc. Methods for enlarging the diameter of a biological conduit in a human subject
US20080025966A1 (en) * 2004-01-30 2008-01-31 Currie Mark G Methods And Compositions For The Treatment Of Gastrointestinal disorders
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
EP1931733A4 (en) * 2005-09-28 2009-11-25 Biovascular Inc Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
EP2316465A1 (en) * 2009-10-15 2011-05-04 Centre National De La Recherche Scientifique Use of extract of leeches' saliva as anti-bacterial agent for the manufacture of different compositons

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808396C2 (en) * 1978-02-27 1984-04-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Protease inhibitors
DE3445532A1 (en) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn HIRUDIN-PA, DESULFATOHIRUDINE-PA, METHOD FOR PRODUCTION AND PHARMACEUTICAL AGENTS THAT CONTAIN THESE ACTIVE SUBSTANCES

Also Published As

Publication number Publication date
CA2053242C (en) 2000-09-19
WO1990012808A1 (en) 1990-11-01
US5397694A (en) 1995-03-14
AU5549290A (en) 1990-11-16
ES2108694T3 (en) 1998-01-01
AU648252B2 (en) 1994-04-21
KR0167344B1 (en) 1999-01-15
ATE157989T1 (en) 1997-09-15
NL8900943A (en) 1990-11-01
KR920701247A (en) 1992-08-11
EP0466833A1 (en) 1992-01-22
CA2053242A1 (en) 1990-10-15
DE69031424D1 (en) 1997-10-16
JP3101629B2 (en) 2000-10-23
JPH04507238A (en) 1992-12-17
EP0466833B1 (en) 1997-09-10
DK0466833T3 (en) 1998-04-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition