DE69018262T2 - Durch polyalkylenglykol verbundene symmetrische dipeptide, ihre herstellung und verwendung in der quantitativen bestimmung von proteasen. - Google Patents

Durch polyalkylenglykol verbundene symmetrische dipeptide, ihre herstellung und verwendung in der quantitativen bestimmung von proteasen.

Info

Publication number
DE69018262T2
DE69018262T2 DE69018262T DE69018262T DE69018262T2 DE 69018262 T2 DE69018262 T2 DE 69018262T2 DE 69018262 T DE69018262 T DE 69018262T DE 69018262 T DE69018262 T DE 69018262T DE 69018262 T2 DE69018262 T2 DE 69018262T2
Authority
DE
Germany
Prior art keywords
dipeptides
proteases
symmetric
production
polyalkylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69018262T
Other languages
English (en)
Other versions
DE69018262D1 (de
Inventor
Gerard Quentin
Jean-Luc Martinoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serbio
Original Assignee
Serbio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serbio filed Critical Serbio
Publication of DE69018262D1 publication Critical patent/DE69018262D1/de
Application granted granted Critical
Publication of DE69018262T2 publication Critical patent/DE69018262T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
DE69018262T 1990-02-19 1990-12-31 Durch polyalkylenglykol verbundene symmetrische dipeptide, ihre herstellung und verwendung in der quantitativen bestimmung von proteasen. Expired - Fee Related DE69018262T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9001964A FR2658521B1 (fr) 1990-02-19 1990-02-19 Bipeptides symetriques comportant un reste polyalkyleneglycol, procede de preparation et utilisation dans le dosage des proteases.
PCT/FR1990/000975 WO1991012263A1 (fr) 1990-02-19 1990-12-31 Bipeptides symetriques comportant un reste polyalkyleneglycol, procede de preparation et utilisation dans le dosage des proteases

Publications (2)

Publication Number Publication Date
DE69018262D1 DE69018262D1 (de) 1995-05-04
DE69018262T2 true DE69018262T2 (de) 1995-10-26

Family

ID=9393863

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69018262T Expired - Fee Related DE69018262T2 (de) 1990-02-19 1990-12-31 Durch polyalkylenglykol verbundene symmetrische dipeptide, ihre herstellung und verwendung in der quantitativen bestimmung von proteasen.

Country Status (6)

Country Link
US (1) US5225532A (de)
EP (1) EP0472670B1 (de)
JP (1) JP2887765B2 (de)
DE (1) DE69018262T2 (de)
FR (1) FR2658521B1 (de)
WO (1) WO1991012263A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229366A (en) * 1990-10-23 1993-07-20 Fuji Photo Film Co., Ltd. Peptide-containing polyethylene glycol derivatives and application thereof
US6417326B1 (en) 1996-04-11 2002-07-09 The University Of British Columbia Fusogenic liposomes
US6495336B1 (en) * 1999-02-23 2002-12-17 Pentapharm Ag Oligopeptide derivatives for the electrochemical measurement of protease activity
JP4734772B2 (ja) * 2001-06-13 2011-07-27 日油株式会社 ポリマー、生体内吸収性材料および組織癒着防止膜
US6908963B2 (en) * 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
WO2004055095A1 (ja) * 2002-12-13 2004-07-01 Nof Corporation ポリマー、生体内吸収性材料及び組織癒着防止膜
JP5486809B2 (ja) * 2006-02-14 2014-05-07 ノボ ノルディスク ヘルス ケア アーゲー Ｃ末端におけるポリペプチドの結合

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409140A (en) * 1979-04-23 1983-10-11 Smith Robert E Substrates and method for determining enzymes
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
JP2524586B2 (ja) * 1985-06-26 1996-08-14 シタス コーポレイション ポリマ−接合を利用する医薬組成物用蛋白質の可溶化
FR2611205B1 (fr) * 1987-02-20 1990-03-02 Serbio Dipeptides, procede de preparation et utilisation dans le dosage de proteases

Also Published As

Publication number Publication date
DE69018262D1 (de) 1995-05-04
JPH04507101A (ja) 1992-12-10
US5225532A (en) 1993-07-06
WO1991012263A1 (fr) 1991-08-22
FR2658521A1 (fr) 1991-08-23
EP0472670A1 (de) 1992-03-04
JP2887765B2 (ja) 1999-04-26
EP0472670B1 (de) 1995-03-29
FR2658521B1 (fr) 1994-01-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee