DE69014404D1 - Biodegradable polyurethanes. - Google Patents

Biodegradable polyurethanes.

Info

Publication number
DE69014404D1
DE69014404D1 DE69014404T DE69014404T DE69014404D1 DE 69014404 D1 DE69014404 D1 DE 69014404D1 DE 69014404 T DE69014404 T DE 69014404T DE 69014404 T DE69014404 T DE 69014404T DE 69014404 D1 DE69014404 D1 DE 69014404D1
Authority
DE
Germany
Prior art keywords
aza
imino
segments
oxygen
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69014404T
Other languages
German (de)
Other versions
DE69014404T2 (en
Inventor
Yoshiharu Kimura
Soonih Kim
Akio Nishiura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69014404D1 publication Critical patent/DE69014404D1/en
Publication of DE69014404T2 publication Critical patent/DE69014404T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30—Low-molecular-weight compounds
    • C08G18/38—Low-molecular-weight compounds having heteroatoms other than oxygen
    • C08G18/3819—Low-molecular-weight compounds having heteroatoms other than oxygen having nitrogen
    • C08G18/3836—Low-molecular-weight compounds having heteroatoms other than oxygen having nitrogen containing azo groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2230/00—Compositions for preparing biodegradable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

A polyurethane (I) of 1000 to 100000 in molecular weight, comprising plural segments, which are each structural units of A-B, A-C and A-D of the formulae: A-B: - @NH-R<1>-NH-@-aza- A-C: - @NH-R<1>-NH-@-Z-R<2>-Z- and A-D: - @NH-R<1>-NH@-O-R<3>-O- the molar proportion of the said segments of A-B, A-C and A-D i.e. x : y : z being 0.01 to 0.8 : 0 to 0.80 : 0 to 0.99, provided that the sum of x, y and z is 1.0; wherein R<1> is a skeleton of a diisocyanate, aza is a group of the formula: <CHEM> wherein Y<1> and Y<2>, represent oxygen, imino (-NH-) and hydrocarbon derivatives thereof; R<4> and R<5> are optional substituents; R<2> is a polyalkylene glycol residue; Z is oxygen or imino; R<3> is alkylene or the residue of an ether or secondary or tertiary amine. The polurethanes are useful for coating medicaments for release in the large intestine.
DE69014404T 1989-03-17 1990-03-16 Biodegradable polyurethanes. Expired - Fee Related DE69014404T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6513689 1989-03-17

Publications (2)

Publication Number Publication Date
DE69014404D1 true DE69014404D1 (en) 1995-01-12
DE69014404T2 DE69014404T2 (en) 1995-05-18

Family

ID=13278168

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69014404T Expired - Fee Related DE69014404T2 (en) 1989-03-17 1990-03-16 Biodegradable polyurethanes.

Country Status (8)

Country Link
EP (1) EP0398472B1 (en)
JP (1) JP2855463B2 (en)
KR (1) KR0158206B1 (en)
AT (1) ATE114681T1 (en)
CA (1) CA2012469C (en)
DE (1) DE69014404T2 (en)
DK (1) DK0398472T3 (en)
ES (1) ES2072976T3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194463B1 (en) * 1991-09-27 1995-06-20 Eastman Kodak Co Light-absorbing polyurethane compositions and thermoplastic polymers colored therewith
DE69229710T2 (en) * 1991-11-15 2000-03-02 Kanegafuchi Chemical Ind Polymers containing ester linkage for pharmaceutical preparations
US5886091A (en) * 1996-01-05 1999-03-23 Milliken & Company Printing ink composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3909497A (en) * 1974-04-12 1975-09-30 Stanford Research Inst Solid polymers thermally degradable to flowable compositions
US4235988A (en) * 1976-12-13 1980-11-25 Imperial Chemical Industries Limited Delivery means for biologically active agents
AU537741B2 (en) * 1979-03-21 1984-07-12 British Technology Group Limited Controlled release compositions
DE3242559A1 (en) * 1982-11-18 1984-05-24 Basf Ag, 6700 Ludwigshafen METHOD FOR THE PRODUCTION OF CELL-MADE POLYURETHANE-POLYHANE MOLDED BODIES, WHEREAS POSSIBLE
US4663308A (en) * 1984-07-18 1987-05-05 Medical College Of Ohio Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract

Also Published As

Publication number Publication date
DK0398472T3 (en) 1995-01-16
EP0398472B1 (en) 1994-11-30
JPH037718A (en) 1991-01-14
CA2012469C (en) 1998-05-12
EP0398472A3 (en) 1991-09-18
JP2855463B2 (en) 1999-02-10
DE69014404T2 (en) 1995-05-18
ES2072976T3 (en) 1995-08-01
CA2012469A1 (en) 1990-09-17
ATE114681T1 (en) 1994-12-15
KR900014451A (en) 1990-10-24
EP0398472A2 (en) 1990-11-22
KR0158206B1 (en) 1999-02-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee