DE68922202T2 - A new thrombomodulin-like glycoprotein available from urine. - Google Patents

A new thrombomodulin-like glycoprotein available from urine.

Info

Publication number
DE68922202T2
DE68922202T2 DE68922202T DE68922202T DE68922202T2 DE 68922202 T2 DE68922202 T2 DE 68922202T2 DE 68922202 T DE68922202 T DE 68922202T DE 68922202 T DE68922202 T DE 68922202T DE 68922202 T2 DE68922202 T2 DE 68922202T2
Authority
DE
Germany
Prior art keywords
urine
thrombomodulin
new
glycoprotein
available
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68922202T
Other languages
German (de)
Other versions
DE68922202D1 (en
Inventor
Yasuyuki Kunihiro
Ryo Tanaka
Michio Ichimura
Akio Uemura
Nobuo Ohzawa
Ei Mochida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE68922202D1 publication Critical patent/DE68922202D1/en
Publication of DE68922202T2 publication Critical patent/DE68922202T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Abstract

This invention relates to a novel anticoagulant substance in human urine, a process for its preparation and a pharmaceutical composition comprising the said substance for the prevention and/or treatment of diseases related to the disorders in blood coagulation system.
DE68922202T 1988-12-27 1989-12-27 A new thrombomodulin-like glycoprotein available from urine. Expired - Fee Related DE68922202T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33041388 1988-12-27
JP28524089 1989-11-01

Publications (2)

Publication Number Publication Date
DE68922202D1 DE68922202D1 (en) 1995-05-18
DE68922202T2 true DE68922202T2 (en) 1995-09-21

Family

ID=26555801

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68929388T Expired - Fee Related DE68929388T2 (en) 1988-12-27 1989-12-27 Anticoagulant compound isolated from urine
DE68922202T Expired - Fee Related DE68922202T2 (en) 1988-12-27 1989-12-27 A new thrombomodulin-like glycoprotein available from urine.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE68929388T Expired - Fee Related DE68929388T2 (en) 1988-12-27 1989-12-27 Anticoagulant compound isolated from urine

Country Status (8)

Country Link
US (2) US5202421A (en)
EP (2) EP0376251B1 (en)
AT (2) ATE121100T1 (en)
AU (2) AU626365B2 (en)
CA (1) CA2006658C (en)
DE (2) DE68929388T2 (en)
ES (1) ES2073425T3 (en)
GR (1) GR3015765T3 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
WO1992000325A1 (en) * 1990-06-27 1992-01-09 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
EP0689843B1 (en) * 1993-12-17 2003-09-10 Mochida Pharmaceutical Co., Ltd. Composition containing soluble thrombomodulins
US5981716A (en) * 1995-06-07 1999-11-09 Gruppo Lepettit, S.P.A. Process for the purification of proteins
EP0871464B1 (en) * 1995-06-09 2003-04-02 The Regents Of The University Of Michigan Bradykinin analogs as selective thrombin inhibitors
JP3745805B2 (en) * 1995-10-24 2006-02-15 日本ケミカルリサーチ株式会社 Purification method of thrombomodulin
US6982249B1 (en) 1997-04-23 2006-01-03 The Regents Of The University Of Michigan Bradykinin analogs as selective inhibitors of cell activation
KR100373480B1 (en) * 1997-10-15 2003-02-25 아사히 가세이 가부시키가이샤 Method for Keeping the Quality of Aqueous Parenteral Solution of Thrombomodulin in Storage and Distribution
DE19749197A1 (en) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Method for determining the anticoagulant potential of a sample
DE19945351C2 (en) * 1999-09-22 2002-04-18 Lohmann Therapie Syst Lts Process for finding and isolating pharmacologically active compounds from mixtures of substances
CN1352087A (en) * 2000-11-02 2002-06-05 上海博德基因开发有限公司 New polypeptide-human glycoprotein 42 and polynucleotide for encoding such polypeptide
MXPA04011337A (en) * 2002-05-17 2005-07-01 Wyeth Corp Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins.
JP2006096668A (en) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd Medicine comprising combination of elastase inhibitor with enzyme inhibitor of blood coagulation system and/or fibrinolysis system
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
CN101522206B (en) * 2006-10-06 2013-03-27 旭化成制药株式会社 Therapeutic and/or ameliorating agent for disseminated intravascular coagulation
AU2008230465B2 (en) 2007-03-23 2011-10-13 Asahi Kasei Pharma Corporation Method for producing high-purity soluble thrombomodulin
JP2011178687A (en) * 2010-02-26 2011-09-15 Kochi Univ Preventive and/or therapeutic agent for pain caused by hematopoietic cell transplantation
AU2011246021B2 (en) 2010-04-30 2014-03-13 Asahi Kasei Pharma Corporation High-purity soluble thrombomodulin and method for producing same
PL2781221T3 (en) 2011-11-15 2020-08-24 Asahi Kasei Pharma Corporation Medicine for treatment and/or improvement of sepsis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4810232B1 (en) * 1970-09-04 1973-04-02
BE791783A (en) * 1972-11-23 1973-05-23 Lilly Co Eli POLYPEPTIDES AND METHOD FOR PREPARING THEM
JPS60199819A (en) * 1984-03-23 1985-10-09 Kowa Co Thrombin binding substance and preparation thereof
JPH0753667B2 (en) * 1985-08-09 1995-06-07 新技術開発事業団 Bone marrow transplant therapy adjuvant
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
JPH0689014B2 (en) * 1986-01-21 1994-11-09 興和株式会社 Thrombin-binding substance and method for producing the same
EP0253331B1 (en) * 1986-07-15 1994-10-19 Kowa Co. Ltd. Thrombin-binding substance and process for its preparation
JPS6330423A (en) * 1986-07-22 1988-02-09 Kowa Co Thrombin-bonding substance and production thereof
JPH0764878B2 (en) * 1986-10-14 1995-07-12 興和株式会社 Anticoagulant and method for producing the same
EP0312598B1 (en) * 1987-01-08 1999-05-26 Asahi Kasei Kogyo Kabushiki Kaisha Peptide functioning to accelerate activation of protein c with thrombin
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
JPH0219399A (en) * 1988-07-05 1990-01-23 Oklahoma Medical Res Found Tronbin bonded polypeptide
JPH0720997B2 (en) * 1988-08-29 1995-03-08 興和株式会社 Novel thrombin-binding substance and method for producing the same
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof

Also Published As

Publication number Publication date
EP0632055B1 (en) 2002-04-10
ATE215967T1 (en) 2002-04-15
DE68922202D1 (en) 1995-05-18
ATE121100T1 (en) 1995-04-15
AU653269B2 (en) 1994-09-22
DE68929388T2 (en) 2002-11-14
CA2006658A1 (en) 1990-06-27
DE68929388D1 (en) 2002-05-16
US5300490A (en) 1994-04-05
EP0376251A2 (en) 1990-07-04
AU2742892A (en) 1993-01-07
CA2006658C (en) 2000-03-28
EP0632055A1 (en) 1995-01-04
AU626365B2 (en) 1992-07-30
GR3015765T3 (en) 1995-07-31
ES2073425T3 (en) 1995-08-16
AU4727889A (en) 1990-08-16
US5202421A (en) 1993-04-13
EP0376251B1 (en) 1995-04-12
EP0376251A3 (en) 1990-12-19

Similar Documents

Publication Publication Date Title
DE68922202T2 (en) A new thrombomodulin-like glycoprotein available from urine.
DE69230112T2 (en) ADVANCED DRUG DELIVERY SYSTEM AND METHOD FOR TREATING PSYCHIATRIC, NEUROLOGICAL AND OTHER DISEASES WITH CARBAMAZEPINE
DE3772429D1 (en) PHARMACEUTICAL PREPARATION FOR TREATING PERIDONTAL DISEASES.
ATE29729T1 (en) NEW INSULIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE, AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF DIABETES MELLITUS.
EP0796623A3 (en) Pharmaceutical preparation for the treatment of blood coagulation disorders
DE68923819T2 (en) Use of gamma-hydroxy butyric acid salts for the manufacture of pharmaceutical compositions for use in the treatment of alcoholism and the compositions prepared.
DE3855921T2 (en) Process and deoxyribonucleic acid for the production of tissue factor protein
ATE66374T1 (en) PREPARATIONS AND METHODS FOR TREATMENT OF BLOOD DISORDERS.
DE3879873D1 (en) PHYSIOLOGICALLY ACTIVE SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IT8322855A0 (en) PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE.
DE3685853D1 (en) AGENTS FOR THE TREATMENT OF BONE DISEASES.
ATE174798T1 (en) THE PREPARATION OF COMPOSITIONS FOR THE TREATMENT OF CELL PROLIFERATION DISEASES
ATE151774T1 (en) CYCLOPENTANPERHYDROPHENANTHRENE-17-BETA-(3-FURYL - 3-DERIVATIVES AND PHARMACEUTICAL PREPARATIONS THEREOF FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
DE3787437T2 (en) SIALOSYL CHOLESTEROL, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS FOR TREATING DISEASES OF THE NERVOUS SYSTEM.
DE3380923D1 (en) PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISORDERS CONDITIONED BY HUMAN DRUGS.
DE3687233T2 (en) PHARMACEUTICAL COMPOSITIONS FOR TREATING SKIN DISEASES.
DK82892D0 (en) APPLICATION OF BRAIN ADDITION FROM BEES AND WHEPS FOR THE PREPARATION OF MEDICINAL PRODUCTS TO TREAT INFECTIONS
DK113789D0 (en) THIOSULPHINIC ACID DERIVATIVES, THEIR USE IN TREATING DISEASE DISEASES AND MEDICINE CONTAINING THESE SUBSTANCES
ATE265225T1 (en) PHARMACEUTICAL PREPARATION CONTAINING A RECEPTOR ANTAGONIST FOR THE TREATMENT OF BLOOD CLOTTING DISORDERS
DK0538690T3 (en) Arylquinolyl-substituted 1,4-dihydropyridine-dicarboxylic acid derivatives, process for their preparation in drug use
DE68905076T2 (en) Pharmaceutical composition for the treatment of skin wounds.
ATE135702T1 (en) ARYL OR HETEROARYL-1-ALKYL-PYRROL-2-CARBOXYLIC ACID DERIVATIVES, FOR THE TREATMENT OF DISEASES CAUSED BY INTERLEUKIN-1
DK417889A (en) USE OF 2-AZABICYCLO (2.2.2.) - CARBOXYLIC ACID DERIVATIVES FOR THE MANUFACTURE OF MEDICAL PRODUCTS FOR THE TREATMENT OF VASCULAR DISEASES

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee