DE68914403T2 - N-Arylierung von Isatinen. - Google Patents

N-Arylierung von Isatinen.

Info

Publication number
DE68914403T2
DE68914403T2 DE68914403T DE68914403T DE68914403T2 DE 68914403 T2 DE68914403 T2 DE 68914403T2 DE 68914403 T DE68914403 T DE 68914403T DE 68914403 T DE68914403 T DE 68914403T DE 68914403 T2 DE68914403 T2 DE 68914403T2
Authority
DE
Germany
Prior art keywords
isatins
arylation
disclosed
reagents
organo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68914403T
Other languages
English (en)
Other versions
DE68914403D1 (de
Inventor
James E Dombrowski
Phillip Gregory Mattingly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE68914403D1 publication Critical patent/DE68914403D1/de
Publication of DE68914403T2 publication Critical patent/DE68914403T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/94—Bismuth compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE68914403T 1988-11-15 1989-11-10 N-Arylierung von Isatinen. Expired - Fee Related DE68914403T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27179988A 1988-11-15 1988-11-15

Publications (2)

Publication Number Publication Date
DE68914403D1 DE68914403D1 (de) 1994-05-11
DE68914403T2 true DE68914403T2 (de) 1994-07-21

Family

ID=23037139

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68914403T Expired - Fee Related DE68914403T2 (de) 1988-11-15 1989-11-10 N-Arylierung von Isatinen.

Country Status (8)

Country Link
EP (1) EP0369344B1 (de)
JP (1) JPH02193966A (de)
KR (1) KR900007800A (de)
AT (1) ATE103895T1 (de)
AU (1) AU630122B2 (de)
CA (1) CA2002708A1 (de)
DE (1) DE68914403T2 (de)
ES (1) ES2054986T3 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5395752A (en) * 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
DE4314318A1 (de) * 1993-04-30 1994-11-03 Henkel Kgaa Isatinderivate zum Färben von keratinhaltigen Fasern
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
WO2001002394A1 (en) 1999-07-01 2001-01-11 Geron Corporation Substituted indole compounds and their use for the treatment of cancer
DE102006046330A1 (de) * 2006-09-28 2008-04-03 Bayer Materialscience Ag Polycarbonate und Copolycarbonate mit verbesserter Metallhaftung
EP2527324A4 (de) 2010-01-20 2013-08-07 Mitsubishi Gas Chemical Co Cyanatesterverbindung und härteprodukt daraus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials

Also Published As

Publication number Publication date
ATE103895T1 (de) 1994-04-15
CA2002708A1 (en) 1990-05-15
EP0369344B1 (de) 1994-04-06
ES2054986T3 (es) 1994-08-16
DE68914403D1 (de) 1994-05-11
EP0369344A1 (de) 1990-05-23
KR900007800A (ko) 1990-06-02
AU630122B2 (en) 1992-10-22
JPH02193966A (ja) 1990-07-31
AU4448389A (en) 1990-05-24

Similar Documents

Publication Publication Date Title
FI854711A0 (fi) Syntetisering av 7-halo-7 -deoxilincomyciner.
NO883304D0 (no) Horisontalt leddet lukkepanel av polykarbonat.
DE3778356D1 (de) Boriertes ueberbasisches material.
DE3787092T2 (de) Präzisionsgerät zum automatischen Zusammenbau und dafür anwendbares Zusammenbauverfahren.
GB8704031D0 (en) Transparent light emitter drive update
DE68914403D1 (de) N-Arylierung von Isatinen.
KR880700775A (ko) 유리의 제조법
GR81852B (de)
KR880700774A (ko) 유리의 제조법
EP0288070A3 (en) Clay-containing material and method for its preparation
DE3885075T2 (de) Antriebsanordnung einer objektivlinse.
FI883759A0 (fi) C.12-modifierade etromycin a-derivat.
DK392287D0 (da) Fremgangsmaade til fremstilling af penem-allyl-estere samt mellemprodukt til brug ved fremgangsmaaden
FR2592636B1 (fr) Conteneur a verre
DE3784029D1 (de) Formularverarbeitungsgeraet mit ferngesteuerter ueberarbeitung.
GB2191572B (en) Light source assembly
DK0433845T3 (da) Fremgangsmåde til fremstilling af 2-acylamino-9-acyl-6-halogen-puriner
DE3774750D1 (de) Folgeverstaerker mit grosser anstiegsgeschwindigkeit.
DE68926210D1 (de) Inkubationsprozess
FR2609280B2 (fr) Conteneur a verre
ES1002496Y (es) Accionamiento regulador de depresion
ATE66459T1 (de) Herstellungsverfahren von trifluormethylverbindungen.
FI871197A0 (fi) Foerfarande foer uppsamling av olja ur vatten samt ett oljeuppsamlingsfartyg foer tillaempning av foerfarandet.
FI874452A0 (fi) Processkontroll vid foerbraenning och slaeckning av kalk samt kaustisering.
FI881154A (fi) Foerfarande foer framstaellning av 5-hydroxidprafenon och dess syraadditionssalter.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee