DE68914201D1 - Diagnosis and treatment of chronic fatigue. - Google Patents

Diagnosis and treatment of chronic fatigue.

Info

Publication number
DE68914201D1
DE68914201D1 DE89304188T DE68914201T DE68914201D1 DE 68914201 D1 DE68914201 D1 DE 68914201D1 DE 89304188 T DE89304188 T DE 89304188T DE 68914201 T DE68914201 T DE 68914201T DE 68914201 D1 DE68914201 D1 DE 68914201D1
Authority
DE
Germany
Prior art keywords
chronic fatigue
diagnosis
treatment
fatigue syndrome
levels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89304188T
Other languages
German (de)
Other versions
DE68914201T2 (en
Inventor
William A Carter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HEM PHARMACEUTICALS CORP ROCKVILLE MD US
HEM Pharmaceuticals Corp
Original Assignee
HEM PHARMACEUTICALS CORP ROCKVILLE MD US
HEM Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HEM PHARMACEUTICALS CORP ROCKVILLE MD US, HEM Pharmaceuticals Corp filed Critical HEM PHARMACEUTICALS CORP ROCKVILLE MD US
Application granted granted Critical
Publication of DE68914201D1 publication Critical patent/DE68914201D1/en
Publication of DE68914201T2 publication Critical patent/DE68914201T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

Chronic Fatigue Syndrome is diagnosed and distinguished from other conditions presenting a similar clinical appearance by assessing the 2 min -5 min A oligonucleotide levels in the patient's circulating peripheral leucocytes and comparing the result obtained to that of healthy individuals. Double-stranded RNAs, notably mismatched dsRNAs, when administered in appropriate amounts, increase the 2 min -5 min A in patients with Chronic Fatigue Syndrome to normal levels and improve the clinical symptoms.
DE68914201T 1988-07-07 1989-04-26 Diagnosis and treatment of chronic fatigue. Expired - Fee Related DE68914201T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22076588A 1988-07-07 1988-07-07

Publications (2)

Publication Number Publication Date
DE68914201D1 true DE68914201D1 (en) 1994-05-05
DE68914201T2 DE68914201T2 (en) 1994-07-14

Family

ID=22824871

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68914201T Expired - Fee Related DE68914201T2 (en) 1988-07-07 1989-04-26 Diagnosis and treatment of chronic fatigue.

Country Status (13)

Country Link
EP (1) EP0350151B1 (en)
CN (1) CN1056747C (en)
AT (1) ATE103493T1 (en)
AU (2) AU3781189A (en)
CA (1) CA1336685C (en)
DE (1) DE68914201T2 (en)
DK (1) DK332289A (en)
ES (2) ES2066847T3 (en)
IE (1) IE63927B1 (en)
IL (1) IL90875A (en)
NZ (1) NZ229849A (en)
PT (1) PT91094B (en)
ZA (1) ZA895143B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005559A1 (en) * 1989-10-16 1991-05-02 Hem Research, Inc. Diagnosis and treatment of neuro-cognitive disorders associated with systemic immunological malfunction
GB9108085D0 (en) * 1991-04-16 1991-06-05 Scras Complexes of polyadenylic acid with polyuridylic acid
US5776690A (en) * 1996-10-07 1998-07-07 Vojdani; Aristo Detection of chronic fatigue syndrome by decreased levels of RNase L inhibitor mRNA
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
CN1796556A (en) 1998-03-20 2006-07-05 联邦科学和工业研究组织 Control of gene expression
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
WO2000044914A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
EP1229134A3 (en) 2001-01-31 2004-01-28 Nucleonics, Inc Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
WO2010104571A2 (en) * 2009-03-13 2010-09-16 Hemispherx Biopharma, Inc. Treating chronic fatigue syndrome and prolonged qt interval
EP3652542A1 (en) * 2017-07-14 2020-05-20 Protea Biopharma N.V. Methods and means for diagnosing and/or treating a fatiguing illness
EP3893893A1 (en) * 2018-12-13 2021-10-20 Aim Immunotech Inc. Methods for improving exercise tolerance in myalgic encephalomyelitis patients

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1326450C (en) * 1985-08-26 1994-01-25 William A. Carter Modulation of aids virus-related events by double stranded rnas (dsrnas)
PH30882A (en) * 1987-03-03 1997-12-23 Hem Res Inc Activated Rnase L as a maker for viral infections.
AU1820388A (en) * 1987-07-17 1989-01-19 Hem Research, Inc. Double stranded rna correction of aberrant metabolic pathways associated with uncontrolled tumor cell and virus growth cycles
ATE122402T1 (en) * 1987-09-04 1995-05-15 Hem Pharma Corp DIAGNOSIS OF DOUBLE-STRANDED RNA DEFICIENCIES.

Also Published As

Publication number Publication date
ATE103493T1 (en) 1994-04-15
AU684288B2 (en) 1997-12-11
EP0350151B1 (en) 1994-03-30
DE68914201T2 (en) 1994-07-14
AU3781189A (en) 1990-01-11
CA1336685C (en) 1995-08-15
IE63927B1 (en) 1995-06-28
EP0350151A2 (en) 1990-01-10
AU6883694A (en) 1994-11-24
NZ229849A (en) 1997-07-27
PT91094A (en) 1990-02-08
ES2066847T3 (en) 1995-03-16
PT91094B (en) 1995-01-31
ZA895143B (en) 1991-04-24
EP0350151A3 (en) 1990-10-03
DK332289D0 (en) 1989-07-04
IL90875A (en) 1994-04-12
IE892180L (en) 1990-01-07
IL90875A0 (en) 1990-02-09
CN1056747C (en) 2000-09-27
CN1039722A (en) 1990-02-21
ES2018903A6 (en) 1991-05-16
DK332289A (en) 1990-01-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee