DE68909167D1 - Amino-chromanol derivatives, processes for their preparation and pharmaceutical compositions containing them. - Google Patents

Amino-chromanol derivatives, processes for their preparation and pharmaceutical compositions containing them.

Info

Publication number
DE68909167D1
DE68909167D1 DE89402857T DE68909167T DE68909167D1 DE 68909167 D1 DE68909167 D1 DE 68909167D1 DE 89402857 T DE89402857 T DE 89402857T DE 68909167 T DE68909167 T DE 68909167T DE 68909167 D1 DE68909167 D1 DE 68909167D1
Authority
DE
Germany
Prior art keywords
image
amino
processes
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89402857T
Other languages
German (de)
Other versions
DE68909167T2 (en
Inventor
Gilbert Regnier
Alain Dhainaut
Jean-Paul Vilaine
Nicole Villeneuve
Ghislaine Joly
Jacques Duhault
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of DE68909167D1 publication Critical patent/DE68909167D1/en
Application granted granted Critical
Publication of DE68909167T2 publication Critical patent/DE68909167T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

New aminochromanol compounds of the formula: <IMAGE> (I) <IMAGE> in which X is cyano, nitro, trifluoromethyl, alkoxycarbonyl, carbamido, dialkylcarbamido, aminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, alkylsulfonylamino or acyl; CH2-R is attached (in the 5 position of the pyrrolidinone nucleus) to an R- or S-configured carbon atom, and R is: either OR' or SR' in which R' is hydrogen, (C1-C10)-alkyl, (C1-C5-alkyl)-carbonyl or <IMAGE> and physiologically tolerable acid addition salts thereof, in the case where R contains a basic function. These compounds and their physiologically tolerable salts can be used in therapeutics for the activation of potassium channels, especially in the treatment of disorders associated with abnormal smooth muscle contraction and in the cardiovascular, bronchopulmonary, digestive, urinary and uterine fields.
DE89402857T 1988-10-17 1989-10-17 Amino-chromanol derivatives, processes for their preparation and pharmaceutical compositions containing them. Expired - Fee Related DE68909167T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8813637A FR2637896B1 (en) 1988-10-17 1988-10-17 NOVEL AMINO CHROMANOL DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
DE68909167D1 true DE68909167D1 (en) 1993-10-21
DE68909167T2 DE68909167T2 (en) 1994-04-14

Family

ID=9371088

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89402857T Expired - Fee Related DE68909167T2 (en) 1988-10-17 1989-10-17 Amino-chromanol derivatives, processes for their preparation and pharmaceutical compositions containing them.

Country Status (15)

Country Link
US (1) US4999372A (en)
EP (1) EP0365416B1 (en)
JP (1) JPH068296B2 (en)
AT (1) ATE94543T1 (en)
AU (1) AU620157B2 (en)
CA (1) CA2000743A1 (en)
DE (1) DE68909167T2 (en)
DK (1) DK492089A (en)
ES (1) ES2059802T3 (en)
FR (1) FR2637896B1 (en)
IE (1) IE64369B1 (en)
NZ (1) NZ231029A (en)
OA (1) OA09430A (en)
PT (1) PT92007B (en)
ZA (1) ZA897821B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1216461B (en) * 1988-02-26 1990-03-08 Milano DERIVATIVES OF 1_ARIL SOLFONIL2_PIRROLIDINONE THEIR PROCESSES OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS.
IT1244881B (en) * 1990-12-13 1994-09-12 Roussel Pharma Spa DERIVATIVES OF 1-ARILSOLFONIL 2-PYROLIDONE, THEIR PREPARATION PROCEDURE AND THE NEW INTERMEDIATES SO OBTAINED, THEIR USE AS DRUGS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
EP0172352B1 (en) * 1984-06-22 1990-08-29 Beecham Group Plc Active benzopyran compounds
GB8625185D0 (en) * 1986-10-21 1986-11-26 Beecham Group Plc Active compounds
ES2058148T3 (en) * 1987-02-04 1994-11-01 Hoechst Ag N-BENZOPYRANIL-LACTAMS SUBSTITUTED WITH ALKYL, PROCEDURE FOR ITS PREPARATION, ITS EMPLOYMENT, AS WELL AS PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS.

Also Published As

Publication number Publication date
DK492089D0 (en) 1989-10-05
JPH02149578A (en) 1990-06-08
IE64369B1 (en) 1995-07-26
DK492089A (en) 1990-04-18
PT92007A (en) 1990-04-30
CA2000743A1 (en) 1990-04-17
JPH068296B2 (en) 1994-02-02
US4999372A (en) 1991-03-12
PT92007B (en) 1995-06-30
NZ231029A (en) 1990-10-26
EP0365416B1 (en) 1993-09-15
ES2059802T3 (en) 1994-11-16
ZA897821B (en) 1990-07-25
FR2637896B1 (en) 1990-11-30
EP0365416A1 (en) 1990-04-25
IE893318L (en) 1990-04-17
DE68909167T2 (en) 1994-04-14
AU4287289A (en) 1990-04-26
FR2637896A1 (en) 1990-04-20
AU620157B2 (en) 1992-02-13
OA09430A (en) 1992-10-15
ATE94543T1 (en) 1993-10-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee