DE68907225D1 - Immunogene, die peptide mit hydrophobem schwanz zur adsorption an das hepatitis b-oberflaechenantigen enthalten. - Google Patents

Immunogene, die peptide mit hydrophobem schwanz zur adsorption an das hepatitis b-oberflaechenantigen enthalten.

Info

Publication number
DE68907225D1
DE68907225D1 DE8989101280T DE68907225T DE68907225D1 DE 68907225 D1 DE68907225 D1 DE 68907225D1 DE 8989101280 T DE8989101280 T DE 8989101280T DE 68907225 T DE68907225 T DE 68907225T DE 68907225 D1 DE68907225 D1 DE 68907225D1
Authority
DE
Germany
Prior art keywords
immunogenes
hepatitis
adsorption
containing peptides
hydrophobic tail
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989101280T
Other languages
English (en)
Other versions
DE68907225T2 (de
Inventor
Alexander R Neurath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York Blood Center Inc
Original Assignee
New York Blood Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Center Inc filed Critical New York Blood Center Inc
Publication of DE68907225D1 publication Critical patent/DE68907225D1/de
Application granted granted Critical
Publication of DE68907225T2 publication Critical patent/DE68907225T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DE89101280T 1988-01-29 1989-01-25 Immunogene, die Peptide mit hydrophobem Schwanz zur Adsorption an das Hepatitis B-Oberflächenantigen enthalten. Expired - Fee Related DE68907225T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/149,789 US5039522A (en) 1988-01-29 1988-01-29 Immunogens containing peptides with an attached hydrophobic tail for adsorption to hepatitis B virus surface antigen

Publications (2)

Publication Number Publication Date
DE68907225D1 true DE68907225D1 (de) 1993-07-29
DE68907225T2 DE68907225T2 (de) 1993-10-07

Family

ID=22531799

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89101280T Expired - Fee Related DE68907225T2 (de) 1988-01-29 1989-01-25 Immunogene, die Peptide mit hydrophobem Schwanz zur Adsorption an das Hepatitis B-Oberflächenantigen enthalten.

Country Status (4)

Country Link
US (1) US5039522A (de)
EP (1) EP0326109B1 (de)
CA (1) CA1333358C (de)
DE (1) DE68907225T2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10299017I2 (de) 1987-06-22 2005-05-25 Medeva Holdings Bv Hepatitis-B-Oberfl{chenantigen enthaltendes Peptid.
JPH03271233A (ja) * 1990-03-19 1991-12-03 Inst Pasteur ウイルスエンベロープ糖タンパク質及びその糖タンパク質の中和エピトープに対応するペプチドの間の相乗作用による、ウイルス性感染に対する防御の誘発
US5876724A (en) * 1990-03-19 1999-03-02 Institut Pasteur Induction of neutralizing antibody against viral infection by synergy between virus envelope glycoprotein and peptides corresponding to neutralization epitopes of the glycoprotein
EP0491077A1 (de) * 1990-12-19 1992-06-24 Medeva Holdings B.V. Zusammensetzung verwendbar als therapeutisches Mittel gegen chronische virale Leberkrankheiten
WO1992011291A1 (en) * 1990-12-20 1992-07-09 Smithkline Beecham Biologicals (S.A.) Vaccines based on hepatitis b surface antigen
DE69223406T2 (de) * 1991-06-19 1998-06-25 New York Medical College M-Protein des Influenzavirus als antivirales Mittel
US5780036A (en) * 1991-08-26 1998-07-14 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus
US6419931B1 (en) 1991-08-26 2002-07-16 Epimmune Inc. Compositions and methods for eliciting CTL immunity
US6322789B1 (en) 1991-08-26 2001-11-27 Epimmune, Inc. HLA-restricted hepatitis B virus CTL epitopes
US6607727B1 (en) * 1991-08-26 2003-08-19 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepatitus B virus
US20110097352A9 (en) * 1992-01-29 2011-04-28 Pharmexa Inc. Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions
US6689363B1 (en) 1992-01-29 2004-02-10 Epimmune Inc. Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions
US7611713B2 (en) * 1993-03-05 2009-11-03 Pharmexa Inc. Inducing cellular immune responses to hepatitis B virus using peptide compositions
US6235288B1 (en) * 1992-08-26 2001-05-22 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
US7029680B1 (en) * 1998-02-03 2006-04-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Delivery of immunogenic molecules vis HBsAg particles
WO1999039736A2 (en) * 1998-02-03 1999-08-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem DELIVERY OF IMMUNOGENIC MOLECULES VIA HBsAg PARTICLES
EP1281761A1 (de) * 2001-07-27 2003-02-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Synthetische Polypeptide die vom pre-S1 Protein des Hepatitis B Virus ableitbar sind und deren Verwendung
EP3187585A1 (de) 2010-03-25 2017-07-05 Oregon Health&Science University Cmv-glycoproteine und rekombinante vektoren
DK2691530T3 (en) 2011-06-10 2018-05-22 Univ Oregon Health & Science CMV GLYCOPROTEIN AND RECOMBINANT VECTORS
EP2568289A3 (de) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunselektion von rekombinantem vesikulärem Stomatitisvirus mit Expression von HIV-1-Proteinen durch Breitbandneutralisierungs-Antikörper
EP2586461A1 (de) 2011-10-27 2013-05-01 Christopher L. Parks Von einem eingehüllten Virus abgeleitete Virenpartikel
EP2679596B1 (de) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 Env-proteinvariante
EP2848937A1 (de) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Verfahren zur Identifizierung neuartiger HIV-1-Immunogene
EP2873423B1 (de) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP3072901A1 (de) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976767A (en) * 1975-04-14 1976-08-24 The New York Blood Center Purification of hepatitis B surface antigen by chromatography on agarose containing aminoalkyl residues
SE8205892D0 (sv) * 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
ZA872203B (en) * 1986-04-28 1988-02-24 New York Blood Center Inc Complex immunogen containing synthetic peptides
US4818527A (en) * 1986-12-09 1989-04-04 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein
EP0294071A3 (de) * 1987-06-03 1990-08-01 Merck & Co. Inc. Impfstoffe gegen Hepatitis B hergestellt mit vorherhergestellten Aluminiumhydroxydengelen und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
US5039522A (en) 1991-08-13
EP0326109B1 (de) 1993-06-23
DE68907225T2 (de) 1993-10-07
EP0326109A3 (en) 1990-05-02
EP0326109A2 (de) 1989-08-02
CA1333358C (en) 1994-12-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee