DE60328383D1 - Zusammensetzungen zur zuführung von nukleinsäuren an zellen - Google Patents

Zusammensetzungen zur zuführung von nukleinsäuren an zellen

Info

Publication number
DE60328383D1
DE60328383D1 DE60328383T DE60328383T DE60328383D1 DE 60328383 D1 DE60328383 D1 DE 60328383D1 DE 60328383 T DE60328383 T DE 60328383T DE 60328383 T DE60328383 T DE 60328383T DE 60328383 D1 DE60328383 D1 DE 60328383D1
Authority
DE
Germany
Prior art keywords
introduction
compositions
cells
nucleic acids
nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60328383T
Other languages
English (en)
Inventor
Sean Monahan
Vladimir Trubetskoy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Mirus Bio Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirus Bio Corp filed Critical Mirus Bio Corp
Application granted granted Critical
Publication of DE60328383D1 publication Critical patent/DE60328383D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
DE60328383T 2002-05-24 2003-05-27 Zusammensetzungen zur zuführung von nukleinsäuren an zellen Expired - Lifetime DE60328383D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38320102P 2002-05-24 2002-05-24
US41133202P 2002-09-17 2002-09-17
PCT/US2003/016577 WO2003099225A2 (en) 2002-05-24 2003-05-27 Compositions for delivering nucleic acids to cells
US10/445,696 US7220400B2 (en) 2002-05-24 2003-05-27 Compositions for delivering nucleic acids to cells

Publications (1)

Publication Number Publication Date
DE60328383D1 true DE60328383D1 (de) 2009-08-27

Family

ID=29554264

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60328383T Expired - Lifetime DE60328383D1 (de) 2002-05-24 2003-05-27 Zusammensetzungen zur zuführung von nukleinsäuren an zellen

Country Status (5)

Country Link
US (3) US7220400B2 (de)
EP (1) EP1507561B1 (de)
DE (1) DE60328383D1 (de)
ES (1) ES2328031T3 (de)
WO (1) WO2003099225A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080281041A1 (en) 1999-06-07 2008-11-13 Rozema David B Reversibly Masked Polymers
US7094605B2 (en) 2001-01-02 2006-08-22 Mirus Bio Corporation Formation of polyampholytes in the presence of a polyion
US8138383B2 (en) * 2002-03-11 2012-03-20 Arrowhead Madison Inc. Membrane active heteropolymers
US8008355B2 (en) * 2002-03-11 2011-08-30 Roche Madison Inc. Endosomolytic poly(vinyl ether) polymers
US7220400B2 (en) * 2002-05-24 2007-05-22 Mirus Bio Corporation Compositions for delivering nucleic acids to cells
WO2006081074A2 (en) * 2005-01-26 2006-08-03 Mirus Bio Corporation Charge neutralization of polyion complexes
US20070100128A1 (en) * 2005-10-28 2007-05-03 Eastman Kodak Company Segmented poly(ethyleneimine) compositions
EP2395012B8 (de) 2005-11-02 2018-06-06 Arbutus Biopharma Corporation Modifizierte siRNA-Moleküle und Verwendungen davon
CN102614528B (zh) * 2006-08-18 2014-02-26 箭头研究公司 用于体内递送多核苷酸的多缀合物
WO2008022468A1 (en) * 2006-08-24 2008-02-28 British Columbia Cancer Agency Branch Compositions and methods for treating myelosuppression
US8290705B2 (en) * 2007-04-25 2012-10-16 Rio Sisa Idea Farm Mobile navigation system with graphic crime-risk display
JP5404612B2 (ja) * 2007-05-08 2014-02-05 ハンツマン・インターナシヨナル・エルエルシー 第三級アミン類または第三級アミノアルキルエーテル類を含んでなる混合物からのｎ，ｎ，ｎ’−トリメチルビスアミノエチルエーテルの分離
AU2008266219B2 (en) 2007-06-19 2013-05-23 Huntsman Petrochemical Llc Reactive amine catalysts for polyurethane foam
WO2009021325A1 (en) 2007-08-10 2009-02-19 British Columbia Cancer Agency Branch Microrna compositions and methods for the treatment of myelogenous leukemia
EP2238251B1 (de) 2007-12-27 2015-02-11 Protiva Biotherapeutics Inc. Silencing der polo-like-kinase-expression unter verwendung von interferenz-rna
CA2721380A1 (en) 2008-04-15 2009-10-22 Protiva Biotherapeutics, Inc. Silencing of csn5 gene expression using interfering rna
WO2010132876A1 (en) * 2009-05-15 2010-11-18 Arizona Board Of Regents For And On Behalf Of Arizona State University Polymers for delivering a substance into a cell
EP3252068A3 (de) 2009-10-12 2018-03-14 Larry J. Smith Verfahren und zusammensetzungen zur modulation der genexpression unter verwendung in-vivo- oder in-vitro-verabreichten arzneistoffen auf oligonukleotidbasis
EP3023495B1 (de) * 2010-02-24 2019-05-08 Arrowhead Pharmaceuticals, Inc. Zusammensetzung für die gezielte freisetzung von sirna
EP2582387A2 (de) 2010-06-17 2013-04-24 The United States Of America As Represented By The Secretary, National Institutes Of Health Zusammensetzungen und verfahren zur behandlung von entzündungserkrankungen
EP2780456A1 (de) 2011-11-17 2014-09-24 The U.S.A. as represented by the Secretary, Department of Health and Human Services Therapeutische rna schalter-zusammensetzungen und anwendungsverfahren dafür
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
BR112014021065A8 (pt) 2012-02-21 2018-04-24 Centre Nat Rech Scient receptores tam como cofatores de entrada do vírus
WO2013124327A1 (en) 2012-02-21 2013-08-29 Institut National De La Sante Et De La Recherche Medicale (Inserm) Tim receptors as virus entry cofactors
US10000545B2 (en) 2012-07-27 2018-06-19 Institut National De La Sante Et De La Recherche Medicale CD147 as receptor for pilus-mediated adhesion of Meningococci to vascular endothelia
AU2015328012A1 (en) 2014-10-02 2017-05-11 Arbutus Biopharma Corporation Compositions and methods for silencing Hepatitis B virus gene expression
US20180245074A1 (en) 2015-06-04 2018-08-30 Protiva Biotherapeutics, Inc. Treating hepatitis b virus infection using crispr
EP3329003A2 (de) 2015-07-29 2018-06-06 Arbutus Biopharma Corporation Zusammensetzungen und verfahren zur ausschaltung einer hepatitis-b-virus-genexpression
US9856481B2 (en) 2015-08-13 2018-01-02 Ann & Robert H. Lurie Children's Hospital MicroRNA treatment of fibrosis
US20200352913A1 (en) 2017-11-23 2020-11-12 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating dengue virus infection
CN110438162B (zh) * 2019-08-22 2021-06-25 广州晶欣生物科技有限公司 一种改良型非脂质体转染试剂盒及其应用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722506B1 (fr) 1994-07-13 1996-08-14 Rhone Poulenc Rorer Sa Composition contenant des acides nucleiques, preparation et utilisations
FR2741066B1 (fr) * 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
US6126964A (en) 1996-01-04 2000-10-03 Mirus Corporation Process of making a compound by forming a polymer from a template drug
US6383811B2 (en) * 1997-12-30 2002-05-07 Mirus Corporation Polyampholytes for delivering polyions to a cell
US6818626B1 (en) * 1998-07-17 2004-11-16 Mirus Corporation Chelating systems for use in the delivery of compounds to cells
US7098032B2 (en) * 2001-01-02 2006-08-29 Mirus Bio Corporation Compositions and methods for drug delivery using pH sensitive molecules
US6881576B2 (en) * 1999-12-31 2005-04-19 Mirus Bio Corporation Formation of polyampholytes in the presence of a polyion
US7098030B2 (en) * 1999-12-31 2006-08-29 Mirus Bio Corporation Polyampholytes for delivering polyions to a cell
US7033607B2 (en) * 1999-12-31 2006-04-25 Mirus Bio Corporation pH-titratable polyampholytes for delivering polyions to a cell
US7094605B2 (en) * 2001-01-02 2006-08-22 Mirus Bio Corporation Formation of polyampholytes in the presence of a polyion
US7220400B2 (en) * 2002-05-24 2007-05-22 Mirus Bio Corporation Compositions for delivering nucleic acids to cells
US6740336B2 (en) * 2002-10-04 2004-05-25 Mirus Corporation Process for generating multilayered particles

Also Published As

Publication number Publication date
US7498017B2 (en) 2009-03-03
WO2003099225A2 (en) 2003-12-04
WO2003099225A3 (en) 2004-04-01
US20090124777A1 (en) 2009-05-14
US20060039860A1 (en) 2006-02-23
EP1507561A2 (de) 2005-02-23
US20030220289A1 (en) 2003-11-27
ES2328031T3 (es) 2009-11-06
EP1507561A4 (de) 2007-08-01
US7220400B2 (en) 2007-05-22
EP1507561B1 (de) 2009-07-15

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8364 No opposition during term of opposition