DE60327007D1 - Procedure for cardiovascular diseases - Google Patents
Procedure for cardiovascular diseasesInfo
- Publication number
- DE60327007D1 DE60327007D1 DE60327007T DE60327007T DE60327007D1 DE 60327007 D1 DE60327007 D1 DE 60327007D1 DE 60327007 T DE60327007 T DE 60327007T DE 60327007 T DE60327007 T DE 60327007T DE 60327007 D1 DE60327007 D1 DE 60327007D1
- Authority
- DE
- Germany
- Prior art keywords
- calprotectin
- antibody
- procedure
- cardiovascular diseases
- body fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 102000001109 Leukocyte L1 Antigen Complex Human genes 0.000 abstract 5
- 108010069316 Leukocyte L1 Antigen Complex Proteins 0.000 abstract 5
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 2
- 210000001124 body fluid Anatomy 0.000 abstract 2
- 239000010839 body fluid Substances 0.000 abstract 2
- 239000002105 nanoparticle Substances 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000004879 turbidimetry Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/02—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from eggs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4727—Calcium binding proteins, e.g. calmodulin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
Abstract
The present invention provides an assay method for the determination of calprotectin in a calprotectin-containing body fluid, said method comprising the steps of:
(a) obtaining a calprotectin-containing liquid sample of, or derived from, said fluid;
(b) contacting said sample of said body fluid with a nanoparticle-bound anti-calprotectin antibody or antibody fragment, to bind said calprotectin; and
(c)assessing the calprotectin content by turbidimetry,
wherein the diameter of the antibody or antibody fragment coated nanoparticles is in the range 65-140 nm.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0229747.1A GB0229747D0 (en) | 2002-12-20 | 2002-12-20 | Assay |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60327007D1 true DE60327007D1 (en) | 2009-05-14 |
Family
ID=9950111
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60317931T Expired - Lifetime DE60317931T2 (en) | 2002-12-20 | 2003-12-22 | CVD ASSAY |
DE60327007T Expired - Lifetime DE60327007D1 (en) | 2002-12-20 | 2003-12-22 | Procedure for cardiovascular diseases |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60317931T Expired - Lifetime DE60317931T2 (en) | 2002-12-20 | 2003-12-22 | CVD ASSAY |
Country Status (16)
Country | Link |
---|---|
US (3) | US10101325B2 (en) |
EP (2) | EP1573335B1 (en) |
JP (2) | JP4653492B2 (en) |
CN (3) | CN101893635B (en) |
AT (2) | ATE380345T1 (en) |
AU (1) | AU2003295142A1 (en) |
CA (2) | CA2504876A1 (en) |
DE (2) | DE60317931T2 (en) |
DK (2) | DK1739430T3 (en) |
ES (2) | ES2323475T3 (en) |
GB (1) | GB0229747D0 (en) |
NO (1) | NO20052161L (en) |
PL (2) | PL394295A1 (en) |
PT (1) | PT1573335E (en) |
SI (1) | SI1573335T1 (en) |
WO (1) | WO2004057341A2 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0229747D0 (en) * | 2002-12-20 | 2003-01-29 | Axis Shield Asa | Assay |
JP4447641B2 (en) | 2004-07-23 | 2010-04-07 | アスペンビオ, ファーマ, インコーポレイテッド | Methods and devices for diagnosing appendicitis |
US7659087B2 (en) | 2004-07-23 | 2010-02-09 | Aspenbio Pharma, Inc. | Methods and devices for diagnosis of appendicitis |
EP1862805A1 (en) * | 2006-06-01 | 2007-12-05 | University of Zürich | The use of mrp 8/14 levels for discrimination of individuals at risk of acute coronary syndromes |
WO2010101950A1 (en) * | 2009-03-02 | 2010-09-10 | Catholic Healthcare West | Diagnostic devices and methods of use |
WO2010128033A2 (en) * | 2009-05-07 | 2010-11-11 | Novozymes A/S | Method for purification of target polypeptides |
US9574977B2 (en) * | 2013-02-26 | 2017-02-21 | Innova Prep | Liquid to liquid biological particle concentrator with disposable fluid path |
EP2511704A1 (en) | 2011-04-13 | 2012-10-17 | Immundiagnostik AG | Assay method for intrinsic acute kidney injury |
NO20110895A1 (en) * | 2011-06-21 | 2012-12-24 | Magne Fagerhol | Competitive S100A9 immunoassays |
ES2402457B2 (en) * | 2011-10-19 | 2014-01-20 | Universidade De Vigo | PROCEDURE FOR THE DIAGNOSIS OF SPILL PLEURAL MALIGNO THROUGH THE DETERMINATION OF THE CONCENTRATION OF CALPROTECTINE IN PLEURAL LIQUID. |
US9122968B2 (en) | 2012-04-03 | 2015-09-01 | X-Card Holdings, Llc | Information carrying card comprising a cross-linked polymer composition, and method of making the same |
US9594999B2 (en) | 2012-04-03 | 2017-03-14 | X-Card Holdings, Llc | Information carrying card comprising crosslinked polymer composition, and method of making the same |
NZ706155A (en) * | 2012-09-12 | 2018-09-28 | Berg Llc | Use of markers in the identification of cardiotoxic agents |
WO2014149926A1 (en) | 2013-03-15 | 2014-09-25 | X-Card Holdings, Llc | Methods of making a core layer for an information carrying card, and resulting products |
WO2018146129A1 (en) * | 2017-02-07 | 2018-08-16 | Orthogenics As | Biomarkers for diagnosing implant related risk of implant revision due to aseptic loosening |
EP3385712A1 (en) | 2017-04-03 | 2018-10-10 | Gentian AS | Improved calprotectin assay |
BR112019023210A2 (en) * | 2017-05-09 | 2020-05-26 | Immundiagnostik Ag | METHOD FOR DETERMINING MEMBERS OF THE S100 FAMILY OF CALCIUM-BINDING PROTEINS THROUGH IMMUNOTURBIDIMETRY |
CN108196066A (en) * | 2018-01-22 | 2018-06-22 | 安徽伊普诺康生物技术股份有限公司 | A kind of kit for measuring calcium sozin and its preparation application method |
CN111819577A (en) | 2018-03-07 | 2020-10-23 | X卡控股有限公司 | Metal card |
CN115836223A (en) * | 2020-05-13 | 2023-03-21 | 北欧生物科技公司 | Calprotectin assay |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
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US4287202A (en) | 1978-05-26 | 1981-09-01 | Horrobin David F | Treatment and/or prophylaxis of spasms of coronary arteries |
JPS55162059A (en) * | 1979-06-05 | 1980-12-17 | Mochida Pharmaceut Co Ltd | Measuring method for antigen, antibody or their complex and measurement reagent kit |
US4401765A (en) * | 1981-09-01 | 1983-08-30 | E. I. Du Pont De Nemours And Company | Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays |
US4480042A (en) * | 1981-10-28 | 1984-10-30 | E. I. Du Pont De Nemours And Company | Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays |
GB8318754D0 (en) * | 1983-07-11 | 1983-08-10 | Fagerhol M K F | Human proteins anti-sera test kits |
JPS60139621A (en) | 1983-12-27 | 1985-07-24 | Grelan Pharmaceut Co Ltd | Antithrombotic agent |
JPS625970A (en) | 1985-03-15 | 1987-01-12 | Terumo Corp | Pyrazine derivative and platelet coagulation inhibitor containing same |
EP0310361A3 (en) * | 1987-09-30 | 1989-05-24 | Beckman Instruments, Inc. | Tridentate conjugate and method of use thereof |
GB2218100A (en) | 1988-03-02 | 1989-11-08 | Erling Sundrehagen | Conjugates for the detection and/or quantification of antigenic substances in body fluids |
ATE139845T1 (en) * | 1989-08-23 | 1996-07-15 | Canon Kk | METHOD FOR MEASURING AN IMMUNOLOGICALLY ACTIVE MATERIAL AND DEVICE SUITABLE FOR THE SAME |
US5455160A (en) * | 1993-05-27 | 1995-10-03 | Fagerhol; Magne K. | Diagnostic test and kit for disease or disorders in the digestive system |
US5776348A (en) * | 1995-02-07 | 1998-07-07 | Massachusetts Institute Of Technology | Mineral precipitation system and method for inhibiting mineral precipitate formation |
PT937259E (en) * | 1996-11-01 | 2005-01-31 | Magne K Fagerhol | PROCESS FOR EXTRACTION OF PROTEINS |
AU7100898A (en) | 1997-04-02 | 1998-10-22 | Brigham And Women's Hospital | Means of ascertaining an individual's risk profile for atherosclerotic disease |
GB9816088D0 (en) | 1998-07-23 | 1998-09-23 | Axis Biochemicals Asa | System |
EP1105739A1 (en) * | 1998-08-20 | 2001-06-13 | Axis-Shield Asa | Assay method for cardiovascular disease |
US7622259B1 (en) * | 1999-07-05 | 2009-11-24 | K.U. Leuven Research & Development | Detection of von-Willebrand factor (vWF) activity |
JP2003508453A (en) | 1999-08-31 | 2003-03-04 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | Systemic inflammatory markers as diagnostic tools in the prevention of atherosclerosis |
FR2800636A1 (en) * | 1999-11-05 | 2001-05-11 | Bio Merieux | COMPOSITE PARTICLES, DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND USES |
US7011952B2 (en) * | 2000-02-22 | 2006-03-14 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
US20030059461A1 (en) * | 2000-06-06 | 2003-03-27 | Sibtech, Inc. | Molecular delivery vehicle for delivery of selected compounds to targets |
DE60139408D1 (en) * | 2000-08-29 | 2009-09-10 | Kyowa Medex Co Ltd | GOOD REPRODUCIBLE AGGLUTINATION IMMUNOASSAY PROCEDURE AND REAGENTS |
JP2002318233A (en) * | 2001-04-19 | 2002-10-31 | Shino Test Corp | Nephelometric measuring reagent and method for measuring substance to be measured |
EP2261669A1 (en) * | 2001-05-04 | 2010-12-15 | Alere San Diego, Inc. | Diagnostic markers of acute coronary syndromes and methods of use thereof |
GB0229747D0 (en) * | 2002-12-20 | 2003-01-29 | Axis Shield Asa | Assay |
FR2872579B1 (en) * | 2004-06-30 | 2006-11-24 | Pasteur Institut | DETECTION OF TUBERCULOSIS AND MYCOBACTERIUM TUBERCULOSIS INFECTION USING HBHA |
US7623910B2 (en) * | 2006-03-10 | 2009-11-24 | University Of Rochester | ECG-based differentiation of LQT1 and LQT2 mutation |
-
2002
- 2002-12-20 GB GBGB0229747.1A patent/GB0229747D0/en not_active Ceased
-
2003
- 2003-12-22 AU AU2003295142A patent/AU2003295142A1/en not_active Abandoned
- 2003-12-22 EP EP03786143A patent/EP1573335B1/en not_active Expired - Lifetime
- 2003-12-22 ES ES06021890T patent/ES2323475T3/en not_active Expired - Lifetime
- 2003-12-22 PL PL394295A patent/PL394295A1/en not_active IP Right Cessation
- 2003-12-22 AT AT03786143T patent/ATE380345T1/en active
- 2003-12-22 SI SI200331123T patent/SI1573335T1/en unknown
- 2003-12-22 DE DE60317931T patent/DE60317931T2/en not_active Expired - Lifetime
- 2003-12-22 JP JP2004561672A patent/JP4653492B2/en not_active Expired - Fee Related
- 2003-12-22 PL PL377476A patent/PL216385B1/en not_active IP Right Cessation
- 2003-12-22 CA CA002504876A patent/CA2504876A1/en not_active Abandoned
- 2003-12-22 DE DE60327007T patent/DE60327007D1/en not_active Expired - Lifetime
- 2003-12-22 US US10/539,797 patent/US10101325B2/en active Active
- 2003-12-22 CN CN201010167371.0A patent/CN101893635B/en not_active Expired - Fee Related
- 2003-12-22 PT PT03786143T patent/PT1573335E/en unknown
- 2003-12-22 WO PCT/GB2003/005607 patent/WO2004057341A2/en active IP Right Grant
- 2003-12-22 DK DK06021890T patent/DK1739430T3/en active
- 2003-12-22 DK DK03786143T patent/DK1573335T3/en active
- 2003-12-22 CA CA2729365A patent/CA2729365C/en not_active Expired - Lifetime
- 2003-12-22 AT AT06021890T patent/ATE427498T1/en active
- 2003-12-22 ES ES03786143T patent/ES2297250T3/en not_active Expired - Lifetime
- 2003-12-22 EP EP06021890A patent/EP1739430B1/en not_active Expired - Lifetime
- 2003-12-22 CN CN2003801069127A patent/CN1729398B/en not_active Expired - Fee Related
- 2003-12-22 CN CN2012100207169A patent/CN102608326A/en active Pending
-
2005
- 2005-05-03 NO NO20052161A patent/NO20052161L/en not_active Application Discontinuation
-
2009
- 2009-09-24 JP JP2009219158A patent/JP5744385B2/en not_active Expired - Fee Related
-
2011
- 2011-06-28 US US13/170,387 patent/US20110318847A1/en not_active Abandoned
-
2018
- 2018-10-15 US US16/159,786 patent/US20190049439A1/en not_active Abandoned
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Legal Events
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8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KUDLEK & GRUNERT PATENTANWAELTE PARTNERSCHAFT, 803 |
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R082 | Change of representative |
Ref document number: 1739430 Country of ref document: EP Representative=s name: KUDLEK & GRUNERT PATENTANWAELTE PARTNERSCHAFT, 803 |