DE60319719T2 - Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie - Google Patents

Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie Download PDF

Info

Publication number
DE60319719T2
DE60319719T2 DE60319719T DE60319719T DE60319719T2 DE 60319719 T2 DE60319719 T2 DE 60319719T2 DE 60319719 T DE60319719 T DE 60319719T DE 60319719 T DE60319719 T DE 60319719T DE 60319719 T2 DE60319719 T2 DE 60319719T2
Authority
DE
Germany
Prior art keywords
gene
cholesterol
patient
pair
haplotype
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60319719T
Other languages
German (de)
English (en)
Other versions
DE60319719D1 (de
Inventor
Sridhar Chicago KUDARAVALLI
Mihael Hristos Potomac POLYMEROPOULOS
Rosarelis Bethesda TORRES
Curt Douglas Germantown WOLFGANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32043422&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60319719(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE60319719D1 publication Critical patent/DE60319719D1/de
Publication of DE60319719T2 publication Critical patent/DE60319719T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60319719T 2002-09-30 2003-09-29 Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie Expired - Lifetime DE60319719T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41512302P 2002-09-30 2002-09-30
US415123P 2002-09-30
PCT/EP2003/010798 WO2004029618A2 (en) 2002-09-30 2003-09-29 Methods to predict cholesterol elevations during immunosuppressant therapy

Publications (2)

Publication Number Publication Date
DE60319719D1 DE60319719D1 (de) 2008-04-24
DE60319719T2 true DE60319719T2 (de) 2009-03-12

Family

ID=32043422

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60319719T Expired - Lifetime DE60319719T2 (de) 2002-09-30 2003-09-29 Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie

Country Status (13)

Country Link
US (2) US7732134B2 (https=)
EP (1) EP1549770B1 (https=)
JP (1) JP4575775B2 (https=)
CN (1) CN100453650C (https=)
AT (1) ATE389034T1 (https=)
AU (1) AU2003287955B2 (https=)
BR (1) BR0314552A (https=)
CA (1) CA2500979A1 (https=)
DE (1) DE60319719T2 (https=)
ES (1) ES2302959T3 (https=)
IL (1) IL167639A (https=)
PT (1) PT1549770E (https=)
WO (1) WO2004029618A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0611021A2 (pt) * 2005-05-31 2010-08-10 Novartis Ag combinação de inibidores de hmg-coa redutase e inibidores de mtor
HUE052213T2 (hu) 2009-11-06 2021-04-28 Univ Leland Stanford Junior Grafitkilökõdés nem invazív diagnosztizálása szervátültetett betegekben
KR101924162B1 (ko) * 2010-03-15 2018-11-30 버지니아 커먼웰스 유니버시티 기도의 염증 및 이상성 점액섬모 전달의 치료법으로서의 에어로졸화 댑손
US20130203769A1 (en) * 2012-02-08 2013-08-08 University Of Cincinnati Targeting Metabolic Adaptive Responses to Chemotherapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686246A (en) 1995-08-03 1997-11-11 Kornman; Kenneth S. Detecting genetic predisposition to periodontal disease
US5698399A (en) * 1996-04-05 1997-12-16 Duff; Gordon W. Detecting genetic predisposition for osteoporosis
US6210877B1 (en) * 1997-03-10 2001-04-03 Interleukin Genetics, Inc. Prediction of coronary artery disease
US6524795B1 (en) 1997-03-10 2003-02-25 Interleukin Genetics, Inc. Diagnostics for cardiovascular disorders
GB9711040D0 (en) * 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
CN1753903B (zh) * 2001-11-19 2010-05-12 白介素遗传公司 影响转录和对炎性和传染性疾病的敏感性的白细胞介素-1基因座的功能多态性

Also Published As

Publication number Publication date
PT1549770E (pt) 2008-06-24
JP2006500930A (ja) 2006-01-12
AU2003287955B2 (en) 2007-06-21
IL167639A (en) 2011-10-31
CN1685062A (zh) 2005-10-19
EP1549770A2 (en) 2005-07-06
AU2003287955B9 (en) 2004-04-19
ATE389034T1 (de) 2008-03-15
WO2004029618A3 (en) 2004-06-17
US7732134B2 (en) 2010-06-08
ES2302959T3 (es) 2008-08-01
HK1084445A1 (zh) 2006-07-28
US20100184798A1 (en) 2010-07-22
JP4575775B2 (ja) 2010-11-04
US20060246439A1 (en) 2006-11-02
WO2004029618A2 (en) 2004-04-08
CN100453650C (zh) 2009-01-21
AU2003287955A1 (en) 2004-04-19
CA2500979A1 (en) 2004-04-08
EP1549770B1 (en) 2008-03-12
BR0314552A (pt) 2005-08-09
DE60319719D1 (de) 2008-04-24

Similar Documents

Publication Publication Date Title
EP2310525B1 (en) Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
EP2841068B1 (en) Crhr1 antagonists for use in the treatment of patients having crh overactivity
EP1673473B1 (en) Use of genetic polymorphisms that associate with efficacy of treatment of inflammatory disease
Abdel-Kahaar et al. The impact of CYP3A4* 22 on tacrolimus pharmacokinetics and outcome in clinical practice at a single kidney transplant center
JP2012507297A (ja) Erbb4遺伝子の多型に基づく精神病及び統合失調症の治療法
US20080166723A1 (en) CDK5 genetic markers associated with galantamine response
AU2003266967B2 (en) Methods for the treatment of dementia based on Apo E genotype
DE60129043T2 (de) Identifizierung von genetischen determinanten der polymorphen cyp3a5 expression
DE60319719T2 (de) Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie
Tapias-Espinosa et al. Oxytocin attenuates schizophrenia-like reduced sensorimotor gating in outbred and inbred rats in line with strain differences in CD38 gene expression
US20050250118A1 (en) EPHX2 Genetic markers associated with galantamine
US20050260613A1 (en) LRPAP1 genetic markers associated with galantamine
US20050048543A1 (en) CHRNA2 genetic markers associated with galantamine response
WO2004042081A1 (de) Spezifische haplotypen des mdr1-gens und deren anwendung in der diagnose und therapie
DE10360956A1 (de) System und Verfahren zum Nachweis von diabetischer Nephropatie oder einer Prädisposition dafür
HK1084445B (en) Methods to predict cholesterol elevations during immunosuppressant therapy
Coresh Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors
Mohammadi The role of VEGF in human organ transplant rejection: Association of VEGF genotype with VEGF production, splice variation, inhibition by immunosuppressive agents and heart graft rejection
Kirchheiner et al. Besonderheiten der Arzneitherapie im Alter unter Berücksichtigung pharmakogenetischer Faktoren
DE102004044374A1 (de) Verwendung einer Genveränderung im Gen des humanen CDCA3-Proteins in der medizinischen Diagnostik und Therapie
DE102005046526A1 (de) Variante des humanen SV2A-Proteins und deren Einfluss auf die Therapieantwort bei Epilepsie

Legal Events

Date Code Title Description
8363 Opposition against the patent
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN