DE60319719T2 - Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie - Google Patents

Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie Download PDF

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Publication number
DE60319719T2
DE60319719T2 DE60319719T DE60319719T DE60319719T2 DE 60319719 T2 DE60319719 T2 DE 60319719T2 DE 60319719 T DE60319719 T DE 60319719T DE 60319719 T DE60319719 T DE 60319719T DE 60319719 T2 DE60319719 T2 DE 60319719T2
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DE
Germany
Prior art keywords
gene
cholesterol
patient
pair
haplotype
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60319719T
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German (de)
English (en)
Other versions
DE60319719D1 (de
Inventor
Sridhar Chicago KUDARAVALLI
Mihael Hristos Potomac POLYMEROPOULOS
Rosarelis Bethesda TORRES
Curt Douglas Germantown WOLFGANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
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Publication date
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Application filed by Novartis AG filed Critical Novartis AG
Publication of DE60319719D1 publication Critical patent/DE60319719D1/de
Application granted granted Critical
Publication of DE60319719T2 publication Critical patent/DE60319719T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60319719T 2002-09-30 2003-09-29 Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie Expired - Lifetime DE60319719T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41512302P 2002-09-30 2002-09-30
US415123P 2002-09-30
PCT/EP2003/010798 WO2004029618A2 (en) 2002-09-30 2003-09-29 Methods to predict cholesterol elevations during immunosuppressant therapy

Publications (2)

Publication Number Publication Date
DE60319719D1 DE60319719D1 (de) 2008-04-24
DE60319719T2 true DE60319719T2 (de) 2009-03-12

Family

ID=32043422

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60319719T Expired - Lifetime DE60319719T2 (de) 2002-09-30 2003-09-29 Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie

Country Status (13)

Country Link
US (2) US7732134B2 (https=)
EP (1) EP1549770B1 (https=)
JP (1) JP4575775B2 (https=)
CN (1) CN100453650C (https=)
AT (1) ATE389034T1 (https=)
AU (1) AU2003287955B2 (https=)
BR (1) BR0314552A (https=)
CA (1) CA2500979A1 (https=)
DE (1) DE60319719T2 (https=)
ES (1) ES2302959T3 (https=)
IL (1) IL167639A (https=)
PT (1) PT1549770E (https=)
WO (1) WO2004029618A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0611021A2 (pt) * 2005-05-31 2010-08-10 Novartis Ag combinação de inibidores de hmg-coa redutase e inibidores de mtor
JP2013509883A (ja) 2009-11-06 2013-03-21 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 臓器移植患者における移植片拒絶反応の非侵襲的診断方法
KR101924162B1 (ko) * 2010-03-15 2018-11-30 버지니아 커먼웰스 유니버시티 기도의 염증 및 이상성 점액섬모 전달의 치료법으로서의 에어로졸화 댑손
US20130203769A1 (en) * 2012-02-08 2013-08-08 University Of Cincinnati Targeting Metabolic Adaptive Responses to Chemotherapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686246A (en) * 1995-08-03 1997-11-11 Kornman; Kenneth S. Detecting genetic predisposition to periodontal disease
US5698399A (en) * 1996-04-05 1997-12-16 Duff; Gordon W. Detecting genetic predisposition for osteoporosis
US6524795B1 (en) 1997-03-10 2003-02-25 Interleukin Genetics, Inc. Diagnostics for cardiovascular disorders
US6210877B1 (en) * 1997-03-10 2001-04-03 Interleukin Genetics, Inc. Prediction of coronary artery disease
GB9711040D0 (en) * 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
WO2003044176A2 (en) * 2001-11-19 2003-05-30 Interleukin Genetics, Inc. Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases

Also Published As

Publication number Publication date
CN1685062A (zh) 2005-10-19
AU2003287955A1 (en) 2004-04-19
JP2006500930A (ja) 2006-01-12
US7732134B2 (en) 2010-06-08
AU2003287955B9 (en) 2004-04-19
HK1084445A1 (zh) 2006-07-28
DE60319719D1 (de) 2008-04-24
US20100184798A1 (en) 2010-07-22
CN100453650C (zh) 2009-01-21
US20060246439A1 (en) 2006-11-02
ATE389034T1 (de) 2008-03-15
WO2004029618A2 (en) 2004-04-08
WO2004029618A3 (en) 2004-06-17
IL167639A (en) 2011-10-31
PT1549770E (pt) 2008-06-24
BR0314552A (pt) 2005-08-09
CA2500979A1 (en) 2004-04-08
EP1549770B1 (en) 2008-03-12
EP1549770A2 (en) 2005-07-06
ES2302959T3 (es) 2008-08-01
AU2003287955B2 (en) 2007-06-21
JP4575775B2 (ja) 2010-11-04

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN