DE60316134D1 - SUBSTITUTED AMINOISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTIDEPRESSIVA - Google Patents

SUBSTITUTED AMINOISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTIDEPRESSIVA

Info

Publication number
DE60316134D1
DE60316134D1 DE60316134T DE60316134T DE60316134D1 DE 60316134 D1 DE60316134 D1 DE 60316134D1 DE 60316134 T DE60316134 T DE 60316134T DE 60316134 T DE60316134 T DE 60316134T DE 60316134 D1 DE60316134 D1 DE 60316134D1
Authority
DE
Germany
Prior art keywords
aminoisoxazoline
antidepressiva
derivatives
substituted
substituted aminoisoxazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60316134T
Other languages
German (de)
Other versions
DE60316134T2 (en
Inventor
Jose Igancio Andres-Gil
Manuel Jesu Alcazar-Vaca
Margaretha Henrica Mari Bakker
Lucas Olivares Ana Isabel De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE60316134D1 publication Critical patent/DE60316134D1/en
Publication of DE60316134T2 publication Critical patent/DE60316134T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE60316134T 2002-04-02 2003-03-27 SUBSTITUTED AMINOISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTIDEPRESSIVA Expired - Lifetime DE60316134T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02076239 2002-04-02
EP02076239 2002-04-02
PCT/EP2003/003245 WO2003082878A1 (en) 2002-04-02 2003-03-27 Substituted amino isoxazoline derivatives and their use as anti-depressants.

Publications (2)

Publication Number Publication Date
DE60316134D1 true DE60316134D1 (en) 2007-10-18
DE60316134T2 DE60316134T2 (en) 2008-05-29

Family

ID=28459528

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60316134T Expired - Lifetime DE60316134T2 (en) 2002-04-02 2003-03-27 SUBSTITUTED AMINOISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTIDEPRESSIVA

Country Status (24)

Country Link
US (1) US7265103B2 (en)
EP (1) EP1492796B1 (en)
JP (1) JP4580653B2 (en)
KR (1) KR20040093061A (en)
CN (1) CN100349897C (en)
AR (1) AR039207A1 (en)
AT (1) ATE372342T1 (en)
BR (1) BR0308309A (en)
CA (1) CA2480113C (en)
DE (1) DE60316134T2 (en)
DK (1) DK1492796T3 (en)
EA (1) EA008189B1 (en)
ES (1) ES2292949T3 (en)
HK (1) HK1080072A1 (en)
HR (1) HRP20040871A2 (en)
IL (2) IL164341A0 (en)
MX (1) MXPA04008626A (en)
NO (1) NO20044645L (en)
NZ (1) NZ536109A (en)
PL (1) PL211708B1 (en)
PT (1) PT1492796E (en)
TW (1) TWI286138B (en)
WO (1) WO2003082878A1 (en)
ZA (1) ZA200407904B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR040967A1 (en) * 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv TRICYCLIC C-SUBSTITUTED ISOXAZOLINE DERIVATIVES AND ITS USE AS ANTI-DEPRESSIVE
AU2003271567B2 (en) * 2002-08-21 2009-12-24 Janssen Pharmaceutica N.V. C6- and C9-substituted chromeno (4, 3-C) isoxazoline derivatives and their use as anti-depressants
ES2331144T3 (en) 2004-11-26 2009-12-22 Janssen Pharmaceutica Nv ISOXAZOLINE-INDOL DERIVATIVES WITH IMPROVED ANTIPSYTICAL AND ANSIOLITIC ACTIVITY.
BRPI0812833A2 (en) * 2007-07-03 2014-12-09 Hoffmann La Roche 4-IMIDAZOLINES AND ITS USE AS ANTIDEPRESSANTS
UY32481A (en) 2009-03-10 2010-09-30 Takeda Pharmaceutical BENZOFURAN DERIVATIVES
US20130062732A1 (en) 2011-09-08 2013-03-14 International Business Machines Corporation Interconnect structures with functional components and methods for fabrication
CN105801510A (en) * 2016-04-08 2016-07-27 李勇 Medicine composition for treating depression

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2055011T3 (en) 1988-09-19 1994-08-16 Akzo Nv A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF TETRAHIDRONAFTALENO AND INDANO.
KR100308748B1 (en) * 1996-01-05 2001-12-12 게리 디. 스트리트, 스티븐 엘. 네스비트 4,5-Dihydronaphth[1,2-C]Isoxazoles and Derivatives Thereof Having CNS Activity
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
MXPA03007432A (en) * 2001-02-21 2003-11-18 Janssen Pharmaceutica Nv Isoxazoline derivatives as anti-depressants.
AR040967A1 (en) * 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv TRICYCLIC C-SUBSTITUTED ISOXAZOLINE DERIVATIVES AND ITS USE AS ANTI-DEPRESSIVE
AU2003271567B2 (en) * 2002-08-21 2009-12-24 Janssen Pharmaceutica N.V. C6- and C9-substituted chromeno (4, 3-C) isoxazoline derivatives and their use as anti-depressants

Also Published As

Publication number Publication date
EA200401297A1 (en) 2005-02-24
WO2003082878A1 (en) 2003-10-09
PL211708B1 (en) 2012-06-29
PT1492796E (en) 2007-11-16
AR039207A1 (en) 2005-02-09
BR0308309A (en) 2004-12-28
IL164341A0 (en) 2005-12-18
KR20040093061A (en) 2004-11-04
ZA200407904B (en) 2005-10-20
US7265103B2 (en) 2007-09-04
JP2005522469A (en) 2005-07-28
EP1492796B1 (en) 2007-09-05
ES2292949T3 (en) 2008-03-16
HK1080072A1 (en) 2006-04-21
IL164341A (en) 2009-06-15
TWI286138B (en) 2007-09-01
NZ536109A (en) 2006-06-30
CA2480113C (en) 2012-04-24
DE60316134T2 (en) 2008-05-29
TW200406414A (en) 2004-05-01
US20050222125A1 (en) 2005-10-06
CN100349897C (en) 2007-11-21
AU2003219111A1 (en) 2003-10-13
EP1492796A1 (en) 2005-01-05
MXPA04008626A (en) 2004-12-06
EA008189B1 (en) 2007-04-27
ATE372342T1 (en) 2007-09-15
NO20044645L (en) 2004-10-27
JP4580653B2 (en) 2010-11-17
PL371630A1 (en) 2005-06-27
DK1492796T3 (en) 2007-12-03
CA2480113A1 (en) 2003-10-09
CN1642960A (en) 2005-07-20
HRP20040871A2 (en) 2005-04-30

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: ANDRES-GIL, JOSE IGANCIO, E-45007 TOLEDO, ES

Inventor name: ALCAZAR-VACA, MANUEL JESU, E- 45007 TOLEDO, ES

Inventor name: BAKKER, MARGARETHA HENRICA MARIA, B-2340 BEERS, BE

Inventor name: DE LUCAS OLIVARES, ANA ISABEL, E-45007 TOLEDO, ES

8364 No opposition during term of opposition