DE60238555D1 - PARATHORMONE ANTIBODIES AND ASSOCIATED METHODS - Google Patents
PARATHORMONE ANTIBODIES AND ASSOCIATED METHODSInfo
- Publication number
- DE60238555D1 DE60238555D1 DE60238555T DE60238555T DE60238555D1 DE 60238555 D1 DE60238555 D1 DE 60238555D1 DE 60238555 T DE60238555 T DE 60238555T DE 60238555 T DE60238555 T DE 60238555T DE 60238555 D1 DE60238555 D1 DE 60238555D1
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- parathormone
- associated methods
- methods
- bind
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
Abstract
Methods of preparing antibodies that recognize and bind three-dimensional epitopes of antigens are disclosed. The methods are particularly useful for preparing antibodies that bind the bioactive, three-dimensional amino terminus of parathyroid hormone. The antibodies so produced are used in diagnostic and therapeutic applications.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/898,398 US20030082179A1 (en) | 2001-07-03 | 2001-07-03 | Parathyroid hormone antibodies and related methods |
PCT/US2002/021356 WO2003003986A2 (en) | 2001-07-03 | 2002-07-03 | Parathyroid hormone antibodies and related methods |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60238555D1 true DE60238555D1 (en) | 2011-01-20 |
Family
ID=25409386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60238555T Expired - Lifetime DE60238555D1 (en) | 2001-07-03 | 2002-07-03 | PARATHORMONE ANTIBODIES AND ASSOCIATED METHODS |
Country Status (7)
Country | Link |
---|---|
US (4) | US20030082179A1 (en) |
EP (1) | EP1455821B1 (en) |
JP (1) | JP2004536831A (en) |
AT (1) | ATE490785T1 (en) |
AU (1) | AU2002354806A1 (en) |
DE (1) | DE60238555D1 (en) |
WO (1) | WO2003003986A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6689566B1 (en) * | 1999-01-14 | 2004-02-10 | Scantibodies Laboratory, Inc. | Methods, kits, and antibodies for detecting parathyroid hormone |
US7820393B2 (en) * | 1999-01-14 | 2010-10-26 | Scantibodies Laboratory, Inc. | Methods, kits and antibodies for detecting parathyroid hormone |
US7226749B2 (en) * | 2000-12-05 | 2007-06-05 | Zahradnik Richard J | Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 |
US7318925B2 (en) * | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
BR0318454A (en) * | 2003-08-08 | 2006-09-12 | Abgenix Inc | parathyroid hormone (pth) targeting antibodies and their uses |
GB0329146D0 (en) * | 2003-12-16 | 2004-01-21 | Glaxosmithkline Biolog Sa | Vaccine |
US7959920B2 (en) * | 2005-09-06 | 2011-06-14 | Scantibodies Laboratory, Inc. | Methods of making and using antibodies directed to parathyroid hormone |
EP2133695A1 (en) * | 2008-06-12 | 2009-12-16 | Koninklijke Philips Electronics N.V. | Parathyroid hormone assay |
BR112012005331A2 (en) † | 2009-09-14 | 2019-09-24 | Koninl Philips Electronics Nv | "Immunoassay for detecting an analyte in a sample, method for detecting analytes in a sample, biosensor device, and appropriate part kit for detecting an analyte in a sample" |
CA2811140C (en) * | 2010-08-31 | 2018-05-29 | Kyowa Medex Co., Ltd. | Method for measuring fibroblast growth factor-23 and reagent therefor |
EP2631247A1 (en) | 2012-02-22 | 2013-08-28 | Immundiagnostik AG | Means and methods of measuring parathyroid hormone in patients suffering from oxidative stress |
EP2775306B1 (en) | 2013-03-08 | 2018-06-27 | Immundiagnostik AG | Non-oxidized, biological active parathyroid hormone determines mortality in hemodialysis patients |
KR101949405B1 (en) * | 2016-10-21 | 2019-02-18 | 이화여자대학교 산학협력단 | Animal model having hypoparathyroidism and method for producing the same |
CN107255726B (en) * | 2017-08-02 | 2018-09-14 | 江苏省原子医学研究所 | Quantitatively detect the fluorescence immune chromatography test paper and preparation method thereof of human parathyroid hormone |
US20200371118A1 (en) | 2018-01-17 | 2020-11-26 | Immundiagnostik Ag | Biomarker predicting coronary artery diseases |
IL284533B2 (en) * | 2019-01-11 | 2024-02-01 | Radius Health Inc | Methods for detecting neutralizing antibodies to parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp) analog |
CN113588602A (en) * | 2021-07-08 | 2021-11-02 | 苏州诺为尔医疗科技有限责任公司 | Rapid parathyroid hormone detection method |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US33188A (en) * | 1861-09-03 | Improvement in mounting glaziers diamonds | ||
US3880934A (en) | 1972-02-10 | 1975-04-29 | Syntex Inc | Nitrophenyloxy-butanediols |
US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
US4066410A (en) * | 1975-09-15 | 1978-01-03 | Nuclear-Medical Laboratories, Inc. | Thyroid hormone assay |
US4380580A (en) * | 1978-04-10 | 1983-04-19 | Miles Laboratories, Inc. | Heterogenous chemiluminescent specific binding assay |
US4369138A (en) * | 1980-07-15 | 1983-01-18 | Immuno Nuclear Corporation | Parathyroid radioimmunoassay |
SE453510B (en) * | 1980-12-29 | 1988-02-08 | Toyo Jozo Kk | PEPTIME FOR ANALYSIS OF HUMANT PARATYROID HORMON |
US4508828A (en) * | 1983-03-21 | 1985-04-02 | Immuno Nuclear Corporation | Bioassay of parathyroid hormone |
EP0273928B1 (en) * | 1986-07-18 | 1997-01-08 | The University Of Melbourne | A PROTEIN ACTIVE IN HUMORAL HYPERCALCEMIA OF MALIGNANCY-PTHrP |
US5744444A (en) * | 1989-10-27 | 1998-04-28 | Haemopep Pharma Gmbh | HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof |
US5395938A (en) * | 1992-08-21 | 1995-03-07 | Nichols Institute Diagnostics | Biotinylated chemiluminescent labels and their conjugates, assays and assay kits |
US5962637A (en) * | 1994-06-03 | 1999-10-05 | Microbiological Research Authority | Toxin assay |
DE4434551A1 (en) | 1994-09-28 | 1996-04-04 | Forssmann Wolf Georg Prof Dr D | Peptides from the sequence of hPTH (1-37) |
JP2729159B2 (en) * | 1994-10-31 | 1998-03-18 | 日清製粉株式会社 | Monoclonal antibody of human glicentin, hybridoma producing the antibody, and method for quantifying human glicentin using the same |
GB9507985D0 (en) * | 1995-04-19 | 1995-06-07 | Orion Yhtymae Oy | Antibody to aminoterminal propeptide to type 1 procollagen and assay method using it |
DE19725365B4 (en) * | 1997-06-16 | 2006-05-24 | C. Rob. Hammerstein Gmbh & Co. Kg | Vehicle seat with forwardly displaceable backrest and forwardly displaceable seat support |
US6689566B1 (en) * | 1999-01-14 | 2004-02-10 | Scantibodies Laboratory, Inc. | Methods, kits, and antibodies for detecting parathyroid hormone |
DE19961350A1 (en) * | 1999-12-17 | 2001-06-21 | Immundiagnostik Ag | Method for determining parathyroid activity in a human sample |
US6838264B2 (en) * | 2000-12-05 | 2005-01-04 | Immutopics, Inc. | Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 |
-
2001
- 2001-07-03 US US09/898,398 patent/US20030082179A1/en not_active Abandoned
-
2002
- 2002-07-03 EP EP02752184A patent/EP1455821B1/en not_active Revoked
- 2002-07-03 WO PCT/US2002/021356 patent/WO2003003986A2/en active Search and Examination
- 2002-07-03 DE DE60238555T patent/DE60238555D1/en not_active Expired - Lifetime
- 2002-07-03 JP JP2003510000A patent/JP2004536831A/en active Pending
- 2002-07-03 AU AU2002354806A patent/AU2002354806A1/en not_active Abandoned
- 2002-07-03 AT AT02752184T patent/ATE490785T1/en not_active IP Right Cessation
-
2004
- 2004-08-18 US US10/921,368 patent/US20050003493A1/en not_active Abandoned
-
2005
- 2005-06-06 US US11/146,598 patent/US20060024772A1/en not_active Abandoned
-
2006
- 2006-05-19 US US11/437,428 patent/US20060286107A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003003986A2 (en) | 2003-01-16 |
WO2003003986A3 (en) | 2004-07-01 |
EP1455821A2 (en) | 2004-09-15 |
US20030082179A1 (en) | 2003-05-01 |
ATE490785T1 (en) | 2010-12-15 |
US20060024772A1 (en) | 2006-02-02 |
JP2004536831A (en) | 2004-12-09 |
EP1455821B1 (en) | 2010-12-08 |
AU2002354806A1 (en) | 2003-01-21 |
US20050003493A1 (en) | 2005-01-06 |
EP1455821A4 (en) | 2006-04-12 |
US20060286107A1 (en) | 2006-12-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60238555D1 (en) | PARATHORMONE ANTIBODIES AND ASSOCIATED METHODS | |
IL163902A0 (en) | Antibodies against cancer antigen tmeff2 and uses thereof | |
TW200510459A (en) | RG1 antibodies and uses thereof | |
HK1109636A1 (en) | Human antibodies and proteins | |
HUP9802212A2 (en) | Recombinant anti-cd4 antibodies for human therapy | |
DE60329489D1 (en) | FUSION PROTEINS HUMANIZED G250-SPECIFIC ANTIBODY AND USES THEREOF | |
GEP20074091B (en) | Cripto blocking antibodies and uses thereof | |
IL195338A (en) | Antibody comprising an fc variant comprising d or e amino acid substitution at position 239 and pharmaceutical composition and use thereof | |
DK1572748T3 (en) | Humanized antibody (H14.18) of mouse 14.18 antibody that binds to GD2 and its fusion protein with IL-2 | |
EP1383785A4 (en) | Recombinant tumor specific antibody and use thereof | |
CY1110033T1 (en) | ARTIFICIAL HUMAN THERAPEUTIC ANTIBODIES AGAINST ISMORPHES CD45 | |
HK1074670A1 (en) | Sets of digital antibodies directed against short epitopes, and methods using same | |
DE602006013428D1 (en) | CHIMAIR RECOMBINANT ANTIGENS OF TOXOPLASMA GONDII | |
DE60018761D1 (en) | THERAPEUTIC ANTIBODIES TO THE MUC-1 ANTIGEN AND METHOD FOR THEIR USE | |
DK1362109T3 (en) | Recombinant oligomeric protein complexes with enhanced immunogenic potential | |
IL221708A0 (en) | Polyclonal goat anti-hla class ii antibody for treatment of disease involving proliferative immune response | |
WO2003104425A3 (en) | Novel stable anti-cd22 antibodies | |
DE69626423D1 (en) | METHOD AND COMPOSITION FOR REFORMING MULTI-EPITOPIC ANTIGENS TO INTRODUCE THE IMMUNE RESPONSE | |
HUP0302681A2 (en) | Javelinization of protein antigens to heat shock proteins | |
GB0008305D0 (en) | Treatment of fungal infections | |
WO2005007673A3 (en) | Immunogenic peptides | |
DE60315827D1 (en) | IMPROVED POLYSACCHARIDE AND GLYCOCONJUGATE VACCINE | |
EP0972054A4 (en) | Enhancement of immune response using targeting molecules | |
CY1106200T1 (en) | ANTIBODIES TO CASPASE-8, THEIR PREPARATION AND USE | |
WO2003106478A3 (en) | ANTIBODIES THAT BIND alphaE INTEGRIN |