DE60233654D1 - Dimerisierter t-zell rezeptor fragment, dessen zusammensetzungen und verwendung - Google Patents
Dimerisierter t-zell rezeptor fragment, dessen zusammensetzungen und verwendungInfo
- Publication number
- DE60233654D1 DE60233654D1 DE60233654T DE60233654T DE60233654D1 DE 60233654 D1 DE60233654 D1 DE 60233654D1 DE 60233654 T DE60233654 T DE 60233654T DE 60233654 T DE60233654 T DE 60233654T DE 60233654 D1 DE60233654 D1 DE 60233654D1
- Authority
- DE
- Germany
- Prior art keywords
- interleukin
- cell receptor
- following infection
- progression
- aids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108091008874 T cell receptors Proteins 0.000 title abstract 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 238000010171 animal model Methods 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000010648 susceptibility to HIV infection Diseases 0.000 abstract 2
- XMVZMBGFIOQONW-GARJFASQSA-N Cys-Lys-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CS)N)C(=O)O XMVZMBGFIOQONW-GARJFASQSA-N 0.000 abstract 1
- HRGGKHFHRSFSDE-CIUDSAMLSA-N His-Asn-Ser Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)O)N HRGGKHFHRSFSDE-CIUDSAMLSA-N 0.000 abstract 1
- ZLFNNVATRMCAKN-ZKWXMUAHSA-N Ile-Ser-Gly Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)NCC(=O)O)N ZLFNNVATRMCAKN-ZKWXMUAHSA-N 0.000 abstract 1
- 102000008070 Interferon-gamma Human genes 0.000 abstract 1
- 108010074328 Interferon-gamma Proteins 0.000 abstract 1
- 102000003814 Interleukin-10 Human genes 0.000 abstract 1
- 108090000174 Interleukin-10 Proteins 0.000 abstract 1
- 102000000588 Interleukin-2 Human genes 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 102000000743 Interleukin-5 Human genes 0.000 abstract 1
- 108010002616 Interleukin-5 Proteins 0.000 abstract 1
- 102000004889 Interleukin-6 Human genes 0.000 abstract 1
- 108090001005 Interleukin-6 Proteins 0.000 abstract 1
- TYYLDKGBCJGJGW-UHFFFAOYSA-N L-tryptophan-L-tyrosine Natural products C=1NC2=CC=CC=C2C=1CC(N)C(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 TYYLDKGBCJGJGW-UHFFFAOYSA-N 0.000 abstract 1
- MAXILRZVORNXBE-PMVMPFDFSA-N Leu-Phe-Trp Chemical compound C([C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)C1=CC=CC=C1 MAXILRZVORNXBE-PMVMPFDFSA-N 0.000 abstract 1
- HKIUVWMZYFBIHG-KKUMJFAQSA-N Tyr-Arg-Gln Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O)N)O HKIUVWMZYFBIHG-KKUMJFAQSA-N 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- 108010020688 glycylhistidine Proteins 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 229940027941 immunoglobulin g Drugs 0.000 abstract 1
- 229960003130 interferon gamma Drugs 0.000 abstract 1
- 229940076144 interleukin-10 Drugs 0.000 abstract 1
- 229940100601 interleukin-6 Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Confectionery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0112126.8A GB0112126D0 (en) | 2001-05-18 | 2001-05-18 | Composition |
| PCT/GB2002/002323 WO2002094860A2 (en) | 2001-05-18 | 2002-05-17 | Dimerized t-cell receptor fragment, its compositions and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60233654D1 true DE60233654D1 (de) | 2009-10-22 |
Family
ID=9914850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60233654T Expired - Lifetime DE60233654D1 (de) | 2001-05-18 | 2002-05-17 | Dimerisierter t-zell rezeptor fragment, dessen zusammensetzungen und verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7998926B2 (de) |
| EP (1) | EP1389219B1 (de) |
| AT (1) | ATE442387T1 (de) |
| AU (1) | AU2002302751A1 (de) |
| DE (1) | DE60233654D1 (de) |
| GB (1) | GB0112126D0 (de) |
| WO (1) | WO2002094860A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7323174B1 (en) * | 2000-06-12 | 2008-01-29 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Modulation of immune response and methods based thereon |
| WO2005087793A2 (en) * | 2004-02-05 | 2005-09-22 | The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Immunostimulatory compositions and uses thereof |
| CA2561376C (en) | 2004-03-30 | 2016-06-21 | Institut Gustave Roussy | Polypeptide sequence involved in the modulation of the immunosuppresive effect of viral proteins |
| WO2005115430A1 (en) * | 2004-05-27 | 2005-12-08 | Gropep Limited | Treatment of inflammatory airway disease |
| US8178649B2 (en) * | 2004-12-07 | 2012-05-15 | Arizona Biomedical Research Commission | Immunostimulatory compositions and uses thereof |
| US8496942B2 (en) * | 2006-12-13 | 2013-07-30 | Susavion Biosciences, Inc. | Therapeutic peptides and uses thereof |
| US7811995B2 (en) * | 2006-12-13 | 2010-10-12 | Susavion Biosciences, Inc. | Therapeutic and diagnostic peptides |
| WO2016175878A1 (en) | 2015-04-27 | 2016-11-03 | Susavion Biosciences, Inc. | Compositions and methods for treating cancer and persistent viral infections |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| SE8405493D0 (sv) | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| DK166762B1 (da) | 1986-01-14 | 1993-07-12 | Nederlanden Staat | Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser |
| US4806352A (en) | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
| WO1991010736A2 (en) * | 1990-01-19 | 1991-07-25 | Dana Farber Cancer Institute | CLONING AND CHARACTERIZATION OF THE CD3θ SUBUNIT |
| WO1992001715A1 (en) | 1990-07-19 | 1992-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | Soluble cell-surface dimeric proteins |
| PL310327A1 (en) | 1993-02-12 | 1995-12-11 | Univ Leland Stanford Junior | Adjustable transcription of target genes and other biological processes |
| AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
| WO1996021028A2 (en) | 1995-01-03 | 1996-07-11 | Procept, Inc. | Soluble heterodimeric t cell receptors and their antibodies |
| US6150337A (en) | 1996-01-23 | 2000-11-21 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes |
| US5714577A (en) * | 1996-01-26 | 1998-02-03 | University Of Pittsburgh | Antimicrobial peptides |
| US6015884A (en) | 1996-03-28 | 2000-01-18 | The Johns Hopkins University | Soluble divalent and multivalent heterodimeric analogs of proteins |
| US5962319A (en) | 1997-05-19 | 1999-10-05 | Bml, Inc. | Human-Th1-specific protein, gene encoding the protein, transformants, recombinant vectors, and antibodies related to the gene |
| US5911990A (en) | 1996-08-13 | 1999-06-15 | Arizona Board Of Regents On Behalf Of The University Of Arizona | T-cell receptor peptides and methods for preventing the progression to AIDS in an animal model |
| IL119938A (en) * | 1996-12-30 | 2005-08-31 | Yissum Res Dev Co | Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells |
| US7323174B1 (en) * | 2000-06-12 | 2008-01-29 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Modulation of immune response and methods based thereon |
-
2001
- 2001-05-18 GB GBGB0112126.8A patent/GB0112126D0/en not_active Ceased
-
2002
- 2002-05-17 DE DE60233654T patent/DE60233654D1/de not_active Expired - Lifetime
- 2002-05-17 US US10/478,194 patent/US7998926B2/en active Active
- 2002-05-17 EP EP02730429A patent/EP1389219B1/de not_active Expired - Lifetime
- 2002-05-17 AU AU2002302751A patent/AU2002302751A1/en not_active Abandoned
- 2002-05-17 AT AT02730429T patent/ATE442387T1/de not_active IP Right Cessation
- 2002-05-17 WO PCT/GB2002/002323 patent/WO2002094860A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002302751A1 (en) | 2002-12-03 |
| EP1389219A2 (de) | 2004-02-18 |
| US20040248192A1 (en) | 2004-12-09 |
| WO2002094860A3 (en) | 2003-06-26 |
| EP1389219B1 (de) | 2009-09-09 |
| US7998926B2 (en) | 2011-08-16 |
| GB0112126D0 (en) | 2001-07-11 |
| WO2002094860A2 (en) | 2002-11-28 |
| ATE442387T1 (de) | 2009-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |