DE602008004337D1 - 2-ETHANSULFONIC ACID SALT FROM N-HYDROXY-4-a5-AE4- (5-ISOPROPYL-2-METHYL-1,3-THIAZOLE-4-YL) PHENOXYPENOXYUENE BENZAMIDINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THEREWITH - Google Patents

2-ETHANSULFONIC ACID SALT FROM N-HYDROXY-4-a5-AE4- (5-ISOPROPYL-2-METHYL-1,3-THIAZOLE-4-YL) PHENOXYPENOXYUENE BENZAMIDINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THEREWITH

Info

Publication number
DE602008004337D1
DE602008004337D1 DE602008004337T DE602008004337T DE602008004337D1 DE 602008004337 D1 DE602008004337 D1 DE 602008004337D1 DE 602008004337 T DE602008004337 T DE 602008004337T DE 602008004337 T DE602008004337 T DE 602008004337T DE 602008004337 D1 DE602008004337 D1 DE 602008004337D1
Authority
DE
Germany
Prior art keywords
benzamidine
isopropyl
hydroxy
methyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008004337T
Other languages
German (de)
Inventor
Jin Soo Lee
Soon Ki Cho
Seoung Kyoo Sung
Young Goo Jin
Jae Hoon Park
Bo Kyung Kim
Ja Hyun Cha
Eun Hee Cho
Jei Man Ryu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong Wha Pharm Co Ltd
Original Assignee
Dong Wha Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Wha Pharm Co Ltd filed Critical Dong Wha Pharm Co Ltd
Publication of DE602008004337D1 publication Critical patent/DE602008004337D1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine 2 ethansulfonic acid salt, a process for the preparation thereof, a pharmaceutical composition for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same, and an oral formulation for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same are described.
DE602008004337T 2007-04-19 2008-04-21 2-ETHANSULFONIC ACID SALT FROM N-HYDROXY-4-a5-AE4- (5-ISOPROPYL-2-METHYL-1,3-THIAZOLE-4-YL) PHENOXYPENOXYUENE BENZAMIDINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THEREWITH Active DE602008004337D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20070038395 2007-04-19
PCT/KR2008/002246 WO2008130172A1 (en) 2007-04-19 2008-04-21 N- hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine 2 ethansulfonic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
DE602008004337D1 true DE602008004337D1 (en) 2011-02-17

Family

ID=39875653

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008004337T Active DE602008004337D1 (en) 2007-04-19 2008-04-21 2-ETHANSULFONIC ACID SALT FROM N-HYDROXY-4-a5-AE4- (5-ISOPROPYL-2-METHYL-1,3-THIAZOLE-4-YL) PHENOXYPENOXYUENE BENZAMIDINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THEREWITH

Country Status (11)

Country Link
US (1) US8039635B2 (en)
EP (1) EP2146974B1 (en)
JP (1) JP5102849B2 (en)
KR (1) KR101006254B1 (en)
CN (1) CN101652355B (en)
AT (1) ATE494282T1 (en)
CA (1) CA2684582C (en)
DE (1) DE602008004337D1 (en)
ES (1) ES2355013T3 (en)
MX (1) MX2009010339A (en)
WO (1) WO2008130172A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006004370A1 (en) * 2004-07-05 2006-01-12 Dong Wha Pharmaceutical. Ind. Co., Ltd. Composition for the prevention and treatment of allergic inflammatory disease
KR20060017929A (en) * 2004-08-04 2006-02-28 동화약품공업주식회사 Novel benzamidine derivatives substituted by thiazole derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100454767B1 (en) 2001-07-19 2004-11-03 동화약품공업주식회사 Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis
WO2006004369A1 (en) 2004-07-05 2006-01-12 Dong Wha Pharmaceutical. Ind. Co., Ltd. Pharmaceutical composition for the treatment of bone fracture
WO2006004370A1 (en) 2004-07-05 2006-01-12 Dong Wha Pharmaceutical. Ind. Co., Ltd. Composition for the prevention and treatment of allergic inflammatory disease
US20070254930A1 (en) 2004-11-23 2007-11-01 Dong Wha Pharm. Ind. Co., Ltd. Oral Preparation Having Improved Bioavailability

Also Published As

Publication number Publication date
CN101652355B (en) 2012-11-07
ATE494282T1 (en) 2011-01-15
ES2355013T3 (en) 2011-03-22
CN101652355A (en) 2010-02-17
EP2146974A4 (en) 2010-04-07
CA2684582A1 (en) 2008-10-30
JP5102849B2 (en) 2012-12-19
WO2008130172A1 (en) 2008-10-30
EP2146974A1 (en) 2010-01-27
JP2010521524A (en) 2010-06-24
US20100113538A1 (en) 2010-05-06
KR20080094634A (en) 2008-10-23
MX2009010339A (en) 2009-10-16
EP2146974B1 (en) 2011-01-05
KR101006254B1 (en) 2011-01-06
CA2684582C (en) 2012-05-29
US8039635B2 (en) 2011-10-18

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