DE602006019701D1 - Verfahren zur insel-isolierung und -transplantation - Google Patents
Verfahren zur insel-isolierung und -transplantationInfo
- Publication number
- DE602006019701D1 DE602006019701D1 DE602006019701T DE602006019701T DE602006019701D1 DE 602006019701 D1 DE602006019701 D1 DE 602006019701D1 DE 602006019701 T DE602006019701 T DE 602006019701T DE 602006019701 T DE602006019701 T DE 602006019701T DE 602006019701 D1 DE602006019701 D1 DE 602006019701D1
- Authority
- DE
- Germany
- Prior art keywords
- islets
- transplantation
- donor
- separated
- isolation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002054 transplantation Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000009413 insulation Methods 0.000 title 1
- 238000002955 isolation Methods 0.000 abstract 3
- 210000000056 organ Anatomy 0.000 abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 210000004185 liver Anatomy 0.000 abstract 2
- 210000000496 pancreas Anatomy 0.000 abstract 2
- 230000035899 viability Effects 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 238000006213 oxygenation reaction Methods 0.000 abstract 1
- 210000003240 portal vein Anatomy 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/080,797 US20060204482A1 (en) | 2005-03-14 | 2005-03-14 | Methods of islet isolation and transplantation |
| PCT/US2006/008390 WO2006099030A2 (en) | 2005-03-14 | 2006-03-09 | Methods of islet isolation and transplantation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006019701D1 true DE602006019701D1 (de) | 2011-03-03 |
Family
ID=36971182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006019701T Active DE602006019701D1 (de) | 2005-03-14 | 2006-03-09 | Verfahren zur insel-isolierung und -transplantation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060204482A1 (de) |
| EP (1) | EP1866429B1 (de) |
| JP (1) | JP2008532547A (de) |
| AT (1) | ATE496119T1 (de) |
| CA (1) | CA2601089A1 (de) |
| DE (1) | DE602006019701D1 (de) |
| WO (1) | WO2006099030A2 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5727167B2 (ja) * | 2010-07-20 | 2015-06-03 | 学校法人福岡大学 | Ｎｃｘを標的とした単離膵島ならびに移植膵島障害の新規制御法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0440925A1 (de) * | 1989-12-13 | 1991-08-14 | The Green Cross Corporation | Aufbewahrungsflüssigkeit und Aufbewahrungsverfahren für innere Organe |
| US5843024A (en) * | 1996-05-17 | 1998-12-01 | Breonics, Inc. | Solution and process for resuscitation and preparation of ischemically damaged tissue |
| US20010055809A1 (en) * | 1998-01-30 | 2001-12-27 | Harpal S. Mangat | Extending tissue preservation |
| DE60026974T2 (de) * | 1999-01-04 | 2007-04-19 | Biomm, Inc., Miami | Neue polymerformulierungen, die perfluorierte verbindungen enthalten, zum konstruieren von zellen und geweben zur transplantation, welche den stoffwechsel und das überleben von zellen verbessern, sowie verfahren zu deren herstellung |
-
2005
- 2005-03-14 US US11/080,797 patent/US20060204482A1/en not_active Abandoned
-
2006
- 2006-03-09 AT AT06737552T patent/ATE496119T1/de not_active IP Right Cessation
- 2006-03-09 DE DE602006019701T patent/DE602006019701D1/de active Active
- 2006-03-09 JP JP2008501918A patent/JP2008532547A/ja not_active Withdrawn
- 2006-03-09 CA CA002601089A patent/CA2601089A1/en not_active Abandoned
- 2006-03-09 EP EP06737552A patent/EP1866429B1/de active Active
- 2006-03-09 WO PCT/US2006/008390 patent/WO2006099030A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| US20060204482A1 (en) | 2006-09-14 |
| EP1866429A4 (de) | 2008-03-26 |
| EP1866429A2 (de) | 2007-12-19 |
| ATE496119T1 (de) | 2011-02-15 |
| CA2601089A1 (en) | 2006-09-21 |
| WO2006099030A2 (en) | 2006-09-21 |
| EP1866429B1 (de) | 2011-01-19 |
| WO2006099030A3 (en) | 2007-04-05 |
| JP2008532547A (ja) | 2008-08-21 |
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