DE602005016228D1 - MICROFLUIDIC MIXING - Google Patents

MICROFLUIDIC MIXING

Info

Publication number
DE602005016228D1
DE602005016228D1 DE602005016228T DE602005016228T DE602005016228D1 DE 602005016228 D1 DE602005016228 D1 DE 602005016228D1 DE 602005016228 T DE602005016228 T DE 602005016228T DE 602005016228 T DE602005016228 T DE 602005016228T DE 602005016228 D1 DE602005016228 D1 DE 602005016228D1
Authority
DE
Germany
Prior art keywords
mixing
aliquots
microconduit
iii
microcavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005016228T
Other languages
German (de)
Inventor
Gerald Jesson
Mats Holmquist
Matthew Fielden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gyros Patent AB
Original Assignee
Gyros Patent AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0400848A external-priority patent/SE0400848D0/en
Application filed by Gyros Patent AB filed Critical Gyros Patent AB
Publication of DE602005016228D1 publication Critical patent/DE602005016228D1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7172—Feed mechanisms characterised by the means for feeding the components to the mixer using capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Led Devices (AREA)

Abstract

A method for mixing two or more aliquots of material, said material being liquid for each of the aliquots except one that may be liquid or a solid material that is dispersed or dissolved in the resulting mixed aliquot, said mixing taking place in a microfluidic mixing unit (100,200,300). The mixing unit comprises: A) a premixing microcavity (103,203,303) that in the upstream direction is connected to said inlet arrangement, and B) a mixing microconduit (104,204,304), and C) an inlet subunit (101,201,301) that in the downstream direction is connected to said premixing microcavity (103,203,303) and/or said mixing microconduit (104,204,304). The method comprises the steps of: i) providing said unit (100,200,300), ii) providing said two or more aliquots in the premixing microcavity (103,203,303), iii) mixing said aliquots in the mixing microconduit (104,204,304), and iv) collecting said resulting mixed aliquot. The characteristic feature is: (A) the mixing unit comprises a vent (111,211,311) in a remote part or end of microconduit (104,204,304), and (B) step (iii) comprises the substeps of: (iii.a) moving said aliquots into said microconduit (104,204,304), and (iii.b) moving said aliquots (104,204,304) in the opposite direction in said microconduit (104,204,304).
DE602005016228T 2004-03-31 2005-03-21 MICROFLUIDIC MIXING Active DE602005016228D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55785004P 2004-03-31 2004-03-31
SE0400848A SE0400848D0 (en) 2004-03-31 2004-03-31 Microfluidic Mixing
PCT/SE2005/000403 WO2005094976A1 (en) 2004-03-31 2005-03-21 Microfluidic mixing

Publications (1)

Publication Number Publication Date
DE602005016228D1 true DE602005016228D1 (en) 2009-10-08

Family

ID=35063568

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005016228T Active DE602005016228D1 (en) 2004-03-31 2005-03-21 MICROFLUIDIC MIXING

Country Status (4)

Country Link
EP (1) EP1729874B1 (en)
AT (1) ATE440658T1 (en)
DE (1) DE602005016228D1 (en)
WO (1) WO2005094976A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110095A1 (en) 2005-04-14 2006-10-19 Gyros Patent Ab A microfluidic device with finger valves
WO2007069940A1 (en) 2005-12-12 2007-06-21 Gyros Patent Ab Microfluidic assays and microfluidic devices
GB201704747D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Reagent mixing system and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1390144A2 (en) * 2001-03-19 2004-02-25 Gyros AB Structural units that define fluidic functions
EP2283924B1 (en) * 2001-08-28 2013-04-17 Gyros Patent Ab Inlet unit with means supporting liquid entrance into a microchannel structure

Also Published As

Publication number Publication date
WO2005094976A1 (en) 2005-10-13
ATE440658T1 (en) 2009-09-15
EP1729874A1 (en) 2006-12-13
EP1729874B1 (en) 2009-08-26

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Legal Events

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8364 No opposition during term of opposition