DE602005013248D1 - AMID DERIVATIVES OF 3-PHENYLDIHYDROPYRIMIDOÄ4,5-DÜPYRIMIDINONES, THEIR PREPARATION AND USE AS PHARMACEUTICAL AGENTS - Google Patents

AMID DERIVATIVES OF 3-PHENYLDIHYDROPYRIMIDOÄ4,5-DÜPYRIMIDINONES, THEIR PREPARATION AND USE AS PHARMACEUTICAL AGENTS

Info

Publication number
DE602005013248D1
DE602005013248D1 DE602005013248T DE602005013248T DE602005013248D1 DE 602005013248 D1 DE602005013248 D1 DE 602005013248D1 DE 602005013248 T DE602005013248 T DE 602005013248T DE 602005013248 T DE602005013248 T DE 602005013248T DE 602005013248 D1 DE602005013248 D1 DE 602005013248D1
Authority
DE
Germany
Prior art keywords
düpyrimidinones
preparation
pharmaceutical agents
derivatives
amid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005013248T
Other languages
German (de)
Inventor
Richard Engh
Hubert Hertenberger
Konrad Honold
Birgit Masjost
Petra Rueger
Wolfgang Schaefer
Stefan Scheiblich
Manfred Schwaiger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602005013248D1 publication Critical patent/DE602005013248D1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
DE602005013248T 2004-08-31 2005-08-30 AMID DERIVATIVES OF 3-PHENYLDIHYDROPYRIMIDOÄ4,5-DÜPYRIMIDINONES, THEIR PREPARATION AND USE AS PHARMACEUTICAL AGENTS Active DE602005013248D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04020598 2004-08-31
PCT/EP2005/009321 WO2006024486A2 (en) 2004-08-31 2005-08-30 Amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents

Publications (1)

Publication Number Publication Date
DE602005013248D1 true DE602005013248D1 (en) 2009-04-23

Family

ID=34926359

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005013248T Active DE602005013248D1 (en) 2004-08-31 2005-08-30 AMID DERIVATIVES OF 3-PHENYLDIHYDROPYRIMIDOÄ4,5-DÜPYRIMIDINONES, THEIR PREPARATION AND USE AS PHARMACEUTICAL AGENTS

Country Status (14)

Country Link
US (1) US7655651B2 (en)
EP (1) EP1789416B1 (en)
JP (1) JP2008510690A (en)
KR (1) KR100853975B1 (en)
CN (1) CN1980933B (en)
AT (1) ATE425166T1 (en)
AU (1) AU2005279336A1 (en)
BR (1) BRPI0514738A (en)
CA (1) CA2576818A1 (en)
DE (1) DE602005013248D1 (en)
ES (1) ES2320570T3 (en)
MX (1) MX2007002096A (en)
RU (1) RU2007111757A (en)
WO (1) WO2006024486A2 (en)

Families Citing this family (34)

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BRPI0413005A (en) * 2003-07-29 2006-09-26 Irm Llc compounds and compositions as protein kinase inhibitors
SA08280783B1 (en) * 2007-01-11 2011-04-24 استرازينيكا ايه بي Pyridopyrimidine Derivatives as PDE4 Inhibitors
TW200835497A (en) * 2007-01-11 2008-09-01 Astrazeneca Ab Chemical compounds 636
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
CA2876689C (en) 2012-06-13 2022-04-26 Incyte Corporation Substituted tricyclic compounds as fgfr inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
TWI647220B (en) 2013-03-15 2019-01-11 美商西建卡爾有限責任公司 Heteroaryl compound and its use
SG11201507478VA (en) 2013-03-15 2015-10-29 Celgene Avilomics Res Inc Heteroaryl compounds and uses thereof
MY181020A (en) 2013-03-15 2020-12-16 Sanofi Sa Heteroaryl compounds and uses thereof
HUE036571T2 (en) 2013-04-19 2018-07-30 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
EP3259269B9 (en) 2015-02-20 2020-03-04 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2018009544A1 (en) 2016-07-05 2018-01-11 The Broad Institute, Inc. Bicyclic urea kinase inhibitors and uses thereof
KR101818130B1 (en) 2016-08-09 2018-01-12 한국과학기술연구원 Therapeutic Agent of Acute Myeloid Leukemia containing 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-d]pyrimidine derivatives
KR101897631B1 (en) * 2016-08-10 2018-09-12 한국과학기술연구원 Urea compounds containing 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one skeleton as protein kinase inhibitors
AU2018226771B2 (en) 2017-02-28 2023-11-23 Dana-Farber Cancer Institute, Inc. Uses of pyrimidopyrimidinones as SIK inhibitors
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
CN109836427B (en) * 2017-11-29 2022-04-15 暨南大学 Pyrimidopyrimidinone compounds and application thereof
US11174257B2 (en) 2018-05-04 2021-11-16 Incyte Corporation Salts of an FGFR inhibitor
CR20200590A (en) 2018-05-04 2021-04-26 Incyte Corp Solid forms of an fgfr inhibitor and processes for preparing the same
CN108610343A (en) * 2018-06-12 2018-10-02 杨文思 A kind of epidermal growth factor receptor inhibitor and its synthetic method for treating cancer
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
KR20220100879A (en) 2019-10-14 2022-07-18 인사이트 코포레이션 Bicyclic heterocycles as FGFR inhibitors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021113479A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CA3162010A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
KR102382613B1 (en) * 2020-01-15 2022-04-06 한국과학기술연구원 7-amino-3,4-dihydropyrimido pyrimidin-2-one derivatives as protein kinase inhibitors and pharmaceutical compositions for treating disease containing the same
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
BR112023004179A2 (en) * 2020-09-16 2023-04-11 Axceso Biopharma Co Ltd PYRIMID PYRIMIDINONE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
AR126102A1 (en) 2021-06-09 2023-09-13 Incyte Corp TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ508268A (en) 1998-05-26 2004-02-27 Warner Lambert Co Bicyclic pyrimidines and bicyclic 3,4- dihydropyrimidines as inhibitors of cellular proliferation
PL347432A1 (en) 1998-10-23 2002-04-08 Hoffmann La Roche Bicyclic nitrogen heterocycles
MXPA02003950A (en) 1999-10-21 2002-10-23 Hoffmann La Roche Heteroalkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase.
CZ20021743A3 (en) 1999-10-21 2002-08-14 F. Hoffmann-La Roche Ag Bicyclic nitrogen heterocycles substituted with alkylamino group functioning together with the group as P38 protein kinase inhibitors
PA8577501A1 (en) 2002-07-25 2004-02-07 Warner Lambert Co KINASE INHIBITORS
US7084270B2 (en) 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
US7112676B2 (en) 2002-11-04 2006-09-26 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
TW200413381A (en) 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
BRPI0413005A (en) * 2003-07-29 2006-09-26 Irm Llc compounds and compositions as protein kinase inhibitors

Also Published As

Publication number Publication date
EP1789416B1 (en) 2009-03-11
CN1980933B (en) 2010-07-14
BRPI0514738A (en) 2008-06-24
KR20070039606A (en) 2007-04-12
MX2007002096A (en) 2007-03-29
RU2007111757A (en) 2008-10-10
AU2005279336A1 (en) 2006-03-09
US20070232611A1 (en) 2007-10-04
US7655651B2 (en) 2010-02-02
ES2320570T3 (en) 2009-05-25
CN1980933A (en) 2007-06-13
ATE425166T1 (en) 2009-03-15
JP2008510690A (en) 2008-04-10
EP1789416A2 (en) 2007-05-30
WO2006024486A2 (en) 2006-03-09
WO2006024486A3 (en) 2006-05-26
KR100853975B1 (en) 2008-08-25
CA2576818A1 (en) 2006-03-09

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