DE602005002562D1 - PYRROLYL SUBSTITUTED PYRIDOE2,3-DIPYRIMIDIN-7-ONE AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS - Google Patents
PYRROLYL SUBSTITUTED PYRIDOE2,3-DIPYRIMIDIN-7-ONE AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTSInfo
- Publication number
- DE602005002562D1 DE602005002562D1 DE602005002562T DE602005002562T DE602005002562D1 DE 602005002562 D1 DE602005002562 D1 DE 602005002562D1 DE 602005002562 T DE602005002562 T DE 602005002562T DE 602005002562 T DE602005002562 T DE 602005002562T DE 602005002562 D1 DE602005002562 D1 DE 602005002562D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- pyridoe2
- dipyrimidin
- derivatives
- therapeutic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
The present invention provides pyrimidines of Formula I: wherein R<SUP>2</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>8 </SUP>and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56790204P | 2004-05-04 | 2004-05-04 | |
US567902P | 2004-05-04 | ||
PCT/IB2005/001141 WO2005105801A1 (en) | 2004-05-04 | 2005-04-22 | Pyrrolyl substituted pyrido[2,3-d]pyrimidin-7-ones and derivatives thereof as therapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE602005002562D1 true DE602005002562D1 (en) | 2007-10-31 |
DE602005002562T2 DE602005002562T2 (en) | 2008-01-31 |
Family
ID=34966564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005002562T Expired - Fee Related DE602005002562T2 (en) | 2004-05-04 | 2005-04-22 | PYRROLYL SUBSTITUTED PYRIDOE2,3-DIPYRIMIDIN-7-ONE AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS |
Country Status (10)
Country | Link |
---|---|
US (1) | US20080255162A1 (en) |
EP (1) | EP1749004B1 (en) |
JP (1) | JP2007536370A (en) |
AT (1) | ATE373659T1 (en) |
BR (1) | BRPI0510560A (en) |
CA (1) | CA2563669A1 (en) |
DE (1) | DE602005002562T2 (en) |
ES (1) | ES2292130T3 (en) |
MX (1) | MXPA06012829A (en) |
WO (1) | WO2005105801A1 (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006302148B2 (en) * | 2005-10-07 | 2012-12-06 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of PI3Kalpha |
NZ594628A (en) * | 2005-10-07 | 2013-04-26 | Exelixis Inc | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Ka |
WO2008021389A2 (en) | 2006-08-16 | 2008-02-21 | Exelixis, Inc. | Using pi3k and mek modulators in treatments of cancer |
PT2074122E (en) | 2006-09-15 | 2011-08-24 | Pfizer Prod Inc | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors |
SI2139484T1 (en) * | 2007-04-10 | 2013-10-30 | Exelixis, Inc. | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha |
CA2683784A1 (en) * | 2007-04-11 | 2008-10-23 | Exelixis, Inc. | Pyrido[2,3-d]pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer |
US20100209340A1 (en) * | 2007-04-11 | 2010-08-19 | Buhr Chris A | Pyrido [2, 3-d] pyrimidin-7-one compounds as inhibitors of p13k-alpha for the treatment of cancer |
WO2009155121A2 (en) | 2008-05-30 | 2009-12-23 | Amgen Inc. | Inhibitors of pi3 kinase |
WO2010039740A1 (en) * | 2008-09-30 | 2010-04-08 | Exelixis, Inc. | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα AND MTOR |
GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
WO2011048936A1 (en) | 2009-10-19 | 2011-04-28 | 大正製薬株式会社 | Aminothiazole derivative |
WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
FR2955109B1 (en) | 2010-01-08 | 2012-09-07 | Sanofi Aventis | 5-OXO-5,8-DIHYDRO-PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
US8901137B2 (en) | 2010-02-09 | 2014-12-02 | Exelixis, Inc. | Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors |
GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
TR201813877T4 (en) | 2012-02-10 | 2018-11-21 | Hoffmann La Roche | COMPOUNDS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY. |
MX2014010176A (en) * | 2012-02-23 | 2014-11-10 | Abbvie Inc | Pyridopyrimidinone inhibitors of kinases. |
US9371336B2 (en) | 2012-03-01 | 2016-06-21 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
KR102109992B1 (en) | 2012-03-23 | 2020-05-13 | 피티씨 테라퓨틱스, 인크. | Compounds for treating spinal muscular atrophy |
WO2015105657A1 (en) | 2013-12-19 | 2015-07-16 | Ptc Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
CA2954189A1 (en) | 2014-07-26 | 2016-02-04 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof |
WO2016196386A1 (en) | 2015-05-30 | 2016-12-08 | Ptc Therapeutics, Inc. | Methods for modulating rna splicing |
LT3386511T (en) | 2015-12-10 | 2021-08-25 | Ptc Therapeutics, Inc. | Methods for treating huntington`s disease |
EA201991309A1 (en) | 2016-11-28 | 2019-11-29 | RNA SPLICING MODULATION METHODS | |
EP3634953B1 (en) | 2017-06-05 | 2024-01-03 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
KR20200017476A (en) | 2017-06-14 | 2020-02-18 | 피티씨 테라퓨틱스, 인크. | How to Change RNA Splicing |
CN111182898B (en) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | Methods for treating huntington's disease |
EP3645121A4 (en) | 2017-06-28 | 2021-03-17 | PTC Therapeutics, Inc. | Methods for treating huntington's disease |
US20210009590A1 (en) | 2018-03-27 | 2021-01-14 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
EP3814360A1 (en) | 2018-06-27 | 2021-05-05 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
EP3814357B1 (en) | 2018-06-27 | 2024-05-01 | PTC Therapeutics, Inc. | Heterocyclic and heteroaryl compounds for treating huntington's disease |
CN114901659A (en) * | 2019-11-26 | 2022-08-12 | 施万生物制药研发Ip有限责任公司 | Fused pyrimidinone compounds as JAK inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100345830C (en) * | 2000-04-27 | 2007-10-31 | 安斯泰来制药有限公司 | Condensed heteroaryl derivatives |
US7019002B2 (en) * | 2001-12-11 | 2006-03-28 | Pharmacia & Upjohn, S.P.A. | Pyridopyrimidinones derivatives as telomerase inhibitors |
US7098332B2 (en) * | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
-
2005
- 2005-04-22 WO PCT/IB2005/001141 patent/WO2005105801A1/en active Application Filing
- 2005-04-22 DE DE602005002562T patent/DE602005002562T2/en not_active Expired - Fee Related
- 2005-04-22 EP EP05733676A patent/EP1749004B1/en active Active
- 2005-04-22 ES ES05733676T patent/ES2292130T3/en active Active
- 2005-04-22 MX MXPA06012829A patent/MXPA06012829A/en unknown
- 2005-04-22 US US11/568,611 patent/US20080255162A1/en not_active Abandoned
- 2005-04-22 BR BRPI0510560-9A patent/BRPI0510560A/en not_active Application Discontinuation
- 2005-04-22 JP JP2007512546A patent/JP2007536370A/en not_active Withdrawn
- 2005-04-22 AT AT05733676T patent/ATE373659T1/en not_active IP Right Cessation
- 2005-04-22 CA CA002563669A patent/CA2563669A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0510560A (en) | 2007-11-20 |
EP1749004B1 (en) | 2007-09-19 |
EP1749004A1 (en) | 2007-02-07 |
ATE373659T1 (en) | 2007-10-15 |
DE602005002562T2 (en) | 2008-01-31 |
US20080255162A1 (en) | 2008-10-16 |
JP2007536370A (en) | 2007-12-13 |
CA2563669A1 (en) | 2005-11-10 |
WO2005105801A1 (en) | 2005-11-10 |
MXPA06012829A (en) | 2007-01-26 |
ES2292130T3 (en) | 2008-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |