DE602004031129D1 - PROCESS FOR THE PREPARATION OF QUETIAPIN - Google Patents

PROCESS FOR THE PREPARATION OF QUETIAPIN

Info

Publication number
DE602004031129D1
DE602004031129D1 DE602004031129T DE602004031129T DE602004031129D1 DE 602004031129 D1 DE602004031129 D1 DE 602004031129D1 DE 602004031129 T DE602004031129 T DE 602004031129T DE 602004031129 T DE602004031129 T DE 602004031129T DE 602004031129 D1 DE602004031129 D1 DE 602004031129D1
Authority
DE
Germany
Prior art keywords
preparation
quetiapin
quetiapine
deprotection
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004031129T
Other languages
German (de)
Inventor
Leif Hilden
Arne Grumann
Soini Huhta
Petteri Rummakko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fermion Oy
Original Assignee
Fermion Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fermion Oy filed Critical Fermion Oy
Publication of DE602004031129D1 publication Critical patent/DE602004031129D1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention discloses a process for the preparation of quetiapine, which comprises the ring closure and deprotection of a compound of the formula (I), as well as novel intermediates in the process.
DE602004031129T 2003-09-23 2004-09-23 PROCESS FOR THE PREPARATION OF QUETIAPIN Active DE602004031129D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50498203P 2003-09-23 2003-09-23
PCT/FI2004/000561 WO2005028459A1 (en) 2003-09-23 2004-09-23 Preparation method for quetiapine

Publications (1)

Publication Number Publication Date
DE602004031129D1 true DE602004031129D1 (en) 2011-03-03

Family

ID=34375549

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031129T Active DE602004031129D1 (en) 2003-09-23 2004-09-23 PROCESS FOR THE PREPARATION OF QUETIAPIN

Country Status (7)

Country Link
US (1) US7858777B2 (en)
EP (1) EP1664009B1 (en)
JP (1) JP2007505865A (en)
AT (1) ATE496038T1 (en)
CA (1) CA2538866A1 (en)
DE (1) DE602004031129D1 (en)
WO (1) WO2005028459A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080065A1 (en) * 2002-03-20 2003-10-02 Teva Pharmaceutical Industries Ltd. Crystalline forms of quetiapine hemifumarate
WO2005028458A1 (en) * 2003-09-23 2005-03-31 Fermion Oy Preparation of quetiapine
EP1869007A1 (en) * 2005-04-14 2007-12-26 Teva Pharmaceutical Industries Ltd Process for preparing quetiapine fumarate
JP2009529062A (en) * 2007-03-29 2009-08-13 テバ ファーマシューティカル インダストリーズ リミティド An improved method for preparing quetiapine fumarate
WO2009004480A2 (en) 2007-05-07 2009-01-08 Actavis Group Ptc Ehf Quetiapine salts and their polymorphs
AU2009208909A1 (en) 2008-01-31 2009-08-06 Fermion Oy A process for the preparation of quetiapine
WO2010100623A1 (en) 2009-03-04 2010-09-10 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA979441A (en) * 1967-02-27 1975-12-09 American Cyanamid Company 11-(piperazinyl) dibenz (b,f) (1,4) oxazepines and analogous thiazepines
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US3458516A (en) * 1968-02-16 1969-07-29 American Cyanamid Co 11-(piperazinyl)dibenz(b,f)(1,4)oxazepines and analogous thiazepines
GB8607684D0 (en) 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
GB8705574D0 (en) 1987-03-10 1987-04-15 Ici Plc Preparation of thiazepine compound
HU227039B1 (en) * 2000-01-25 2010-05-28 Egis Gyogyszergyar Nyilvanosan New process for the production of quetiapine and intermediates therefor
WO2005028458A1 (en) * 2003-09-23 2005-03-31 Fermion Oy Preparation of quetiapine

Also Published As

Publication number Publication date
US20070111986A1 (en) 2007-05-17
US7858777B2 (en) 2010-12-28
EP1664009A1 (en) 2006-06-07
CA2538866A1 (en) 2005-03-31
JP2007505865A (en) 2007-03-15
WO2005028459A1 (en) 2005-03-31
EP1664009B1 (en) 2011-01-19
ATE496038T1 (en) 2011-02-15

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