DE602004031088D1 - Mutierte SREBP-1c Promoteren und deren Verwendung - Google Patents
Mutierte SREBP-1c Promoteren und deren VerwendungInfo
- Publication number
- DE602004031088D1 DE602004031088D1 DE602004031088T DE602004031088T DE602004031088D1 DE 602004031088 D1 DE602004031088 D1 DE 602004031088D1 DE 602004031088 T DE602004031088 T DE 602004031088T DE 602004031088 T DE602004031088 T DE 602004031088T DE 602004031088 D1 DE602004031088 D1 DE 602004031088D1
- Authority
- DE
- Germany
- Prior art keywords
- srebp
- promoters
- mutant
- metabolic disorder
- inactivated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000008078 Sterol Regulatory Element Binding Protein 1 Human genes 0.000 title 1
- 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 title 1
- 208000030159 metabolic disease Diseases 0.000 abstract 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940043274 prophylactic drug Drugs 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003043398 | 2003-02-20 | ||
| JP2003160856 | 2003-06-05 | ||
| PCT/JP2004/001924 WO2004074475A1 (ja) | 2003-02-20 | 2004-02-19 | 転写制御シスエレメント及びそれに特異的に結合する転写調節因子並びにそれらの用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004031088D1 true DE602004031088D1 (de) | 2011-03-03 |
Family
ID=32911421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004031088T Expired - Lifetime DE602004031088D1 (de) | 2003-02-20 | 2004-02-19 | Mutierte SREBP-1c Promoteren und deren Verwendung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070032643A1 (de) |
| EP (1) | EP1600507B1 (de) |
| AT (1) | ATE496126T1 (de) |
| DE (1) | DE602004031088D1 (de) |
| WO (1) | WO2004074475A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0304860A (pt) * | 2002-11-11 | 2004-08-31 | Ajinomoto Kk | Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia |
| CN104946579A (zh) * | 2015-07-03 | 2015-09-30 | 浙江大学 | 一种金华猪乳腺上皮细胞系的培养方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030224515A1 (en) * | 2002-06-04 | 2003-12-04 | Isis Pharmaceuticals Inc. | Antisense modulation of sterol regulatory element-binding protein-1 expression |
-
2004
- 2004-02-19 WO PCT/JP2004/001924 patent/WO2004074475A1/ja active Application Filing
- 2004-02-19 DE DE602004031088T patent/DE602004031088D1/de not_active Expired - Lifetime
- 2004-02-19 AT AT04712761T patent/ATE496126T1/de not_active IP Right Cessation
- 2004-02-19 US US10/546,096 patent/US20070032643A1/en not_active Abandoned
- 2004-02-19 EP EP04712761A patent/EP1600507B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1600507A1 (de) | 2005-11-30 |
| ATE496126T1 (de) | 2011-02-15 |
| EP1600507A4 (de) | 2006-07-19 |
| WO2004074475A1 (ja) | 2004-09-02 |
| US20070032643A1 (en) | 2007-02-08 |
| EP1600507B1 (de) | 2011-01-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60231316D1 (de) | VERWENDUNG VON BISPEZIFISCHEN ANTIKÖRPERN GEGEN EINEN AKTIVIERENDEN REZEPTOR FcEpsilonRI UND GEGEN EINEN INHIBIERENDEN REZEPTOR OX2Ra (CD200Ra) ZUR REGULIERUNG DER IMMUNANTWORTEN | |
| CY1124111T1 (el) | Παραγοντες ρυθμισης γλουταμικου στην αντιμετωπιση ψυχικων διαταραχων | |
| ATE496636T1 (de) | Verwendung von agonisten und antagonisten von interleukin-33 (il-33) | |
| NO20082473L (no) | Fremgangsmater, sammensetninger og sett for behandling av medisinske tilstander | |
| DK1287364T3 (da) | Diagnostisk og terapi til makulære degenerationsrelaterede lidelser | |
| NO20034966D0 (no) | Elektronisk styrt aktiv opphengsdemper | |
| DK1660057T3 (da) | Kombinationsterapi til behandling af neovaskulære øjenlidelser | |
| DE60324219D1 (de) | Elektrophotographisches, lichtempfindliches Element, Prozesskartusche und elektrophotographischer Apparat | |
| DE602004002147D1 (de) | Apparat für kardiopulmonäre Reanimation mit Feedback von Messungen des Pulses und/oder des Sauerstoffgehalts des Blutes | |
| AU4929701A (en) | Whole-body optical imaging of gene expression and uses thereof | |
| DE50310246D1 (de) | N leitwertsensor enthaltenden kontrolleinheit | |
| ITRM20070351A1 (it) | Gene codificante la proteina ambra 1 avente attivita' regolatoria dell autofagia e dello sviluppo del sistema nervoso centrale | |
| ATE537847T1 (de) | Biologische vorrichtung zur regulierung der genexpression | |
| DE602006019861D1 (de) | Säule und kassettensäule unter verwendung davon | |
| DE602005027322D1 (de) | Verwendung von antikörpern gegen tweak zur behandlung von schlaganfall | |
| ATE525480T1 (de) | Verwendung von a33-antigenen und jam-it | |
| NO20072285L (no) | S-mirtazapin for behandling av hetetokter | |
| DE59813690D1 (de) | Substituierte heterocyclen und deren verwendung in arzneimitteln | |
| DE60336068D1 (de) | Antikörper gerichtet gegen oxidierten Apolipoprotein B | |
| DE602004031088D1 (de) | Mutierte SREBP-1c Promoteren und deren Verwendung | |
| DE602004021214D1 (de) | Regelstrecke mit Kompensation von Störgrössen | |
| BR0313588A (pt) | Métodos para o tratamento da demência com base em apo e genótipo | |
| ATE489628T1 (de) | Galk1s als modifikatoren des pten/akt-wegs | |
| FI20041572A (fi) | Kasvihuone, kasvihuoneen ilmastonsäätöjärjestelmä ja menetelmä kasvihuoneen ilmaston säätämiseksi | |
| ATE445592T1 (de) | Derivate von heteroarylalkylcarbamaten, verfahren zu deren herstellung und deren verwendung als faah-enzyminhibitoren |