DE602004027824D1 - ANTITUMORAL AGENT WITH A HISTON DEACETYLASE INHIBITOR AND A TOPOISOMERASE II HEMMER - Google Patents

ANTITUMORAL AGENT WITH A HISTON DEACETYLASE INHIBITOR AND A TOPOISOMERASE II HEMMER

Info

Publication number
DE602004027824D1
DE602004027824D1 DE602004027824T DE602004027824T DE602004027824D1 DE 602004027824 D1 DE602004027824 D1 DE 602004027824D1 DE 602004027824 T DE602004027824 T DE 602004027824T DE 602004027824 T DE602004027824 T DE 602004027824T DE 602004027824 D1 DE602004027824 D1 DE 602004027824D1
Authority
DE
Germany
Prior art keywords
topoisomerase
hemmer
deacetylase inhibitor
histon deacetylase
antitumoral agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004027824T
Other languages
German (de)
Inventor
Yoshinori Naoe
Yuka Sasakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of DE602004027824D1 publication Critical patent/DE602004027824D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

A compound of formula I: or a pharmaceutically acceptable salt thereof, in combination with a topoisomerase II inhibitor, except amrubicin and a pharmaceutically acceptable salt thereof, for use in treatment of cancer.
DE602004027824T 2003-09-25 2004-09-24 ANTITUMORAL AGENT WITH A HISTON DEACETYLASE INHIBITOR AND A TOPOISOMERASE II HEMMER Expired - Lifetime DE602004027824D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003334340 2003-09-25
JP2003344315 2003-10-02
PCT/JP2004/014451 WO2005030239A2 (en) 2003-09-25 2004-09-24 Antitumor agent comprising a histone deacetylase inhibitor and a topoisomerase ii inhibitor

Publications (1)

Publication Number Publication Date
DE602004027824D1 true DE602004027824D1 (en) 2010-08-05

Family

ID=34380371

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004027824T Expired - Lifetime DE602004027824D1 (en) 2003-09-25 2004-09-24 ANTITUMORAL AGENT WITH A HISTON DEACETYLASE INHIBITOR AND A TOPOISOMERASE II HEMMER

Country Status (14)

Country Link
US (1) US7314862B2 (en)
EP (2) EP1670514B1 (en)
JP (1) JP4779971B2 (en)
AT (1) ATE471740T1 (en)
CA (1) CA2540108A1 (en)
CY (1) CY1114359T1 (en)
DE (1) DE602004027824D1 (en)
DK (1) DK2263694T3 (en)
ES (2) ES2425083T3 (en)
MX (1) MXPA06003222A (en)
PL (2) PL2263694T3 (en)
PT (1) PT2263694E (en)
SI (1) SI2263694T1 (en)
WO (1) WO2005030239A2 (en)

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PT1426054E (en) * 2001-08-21 2011-12-06 Astellas Pharma Inc Medicinal use of histone deacetylase inhibitor and method of evaluating antitumor effect thereof
AU2003219555A1 (en) * 2002-04-05 2003-10-20 Fujisawa Pharmaceutical Co., Ltd. Depsipeptide for therapy of kidney cancer
WO2004074478A1 (en) * 2003-02-19 2004-09-02 Astellas Pharma Inc. Method of estimating antitumor effect of histone deacetylase inhibitor
US7375228B2 (en) * 2003-03-17 2008-05-20 Takeda San Diego, Inc. Histone deacetylase inhibitors
PL2263694T3 (en) 2003-09-25 2013-11-29 Astellas Pharma Inc Antitumor agent comprising the histone deacetylase inhibitor FK228 and the topoisomerase II inhibitor doxorubicin
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
US20050159470A1 (en) * 2003-12-19 2005-07-21 Syrrx, Inc. Histone deacetylase inhibitors
US7951780B2 (en) * 2004-02-25 2011-05-31 Astellas Pharma Inc. Antitumor agent
WO2006066133A2 (en) * 2004-12-16 2006-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP1896436A2 (en) * 2005-05-11 2008-03-12 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7732475B2 (en) * 2005-07-14 2010-06-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2007040522A1 (en) * 2005-09-30 2007-04-12 The Ohio State Research Foundation Antitumor agents
JP2009519224A (en) * 2005-11-18 2009-05-14 グロスター ファーマシューティカルズ， インコーポレイテッド Metabolite derivatives of HDAC inhibitor FK228
JP2009525955A (en) * 2006-01-13 2009-07-16 タケダ サン ディエゴ インコーポレイテッド Histone deacetylase inhibitor
WO2008013589A2 (en) * 2006-04-24 2008-01-31 Gloucester Pharmaceuticals Treatment of ras-expressing tumors
WO2007146730A2 (en) 2006-06-08 2007-12-21 Gloucester Pharmaceuticals Deacetylase inhibitor therapy
RU2446796C2 (en) 2006-12-26 2012-04-10 Фармасайкликс, Инк. Method for using histone deacetylase and biomarker monitoring in combined therapy
AU2007342030B2 (en) * 2006-12-29 2013-08-15 Celgene Corporation Romidepsin-based treatments for cancer
CN107090482A (en) 2006-12-29 2017-08-25 细胞基因公司 Prepare Romidepsin
WO2009002941A1 (en) * 2007-06-22 2008-12-31 Board Of Regents, The University Of Texas System Composition and method for the treatment of diseases affected by histone deacetylase inhibitors
US20110021517A1 (en) * 2008-02-26 2011-01-27 Nerviano Medical Sciences S.R.L. Antitumor combination comprising a morpholinyl anthracycline derivative and demethylating agents
WO2012009336A1 (en) * 2010-07-12 2012-01-19 Gloucester Pharmaceuticals, Inc. Romidepsin solid forms and uses thereof
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
CN103917231B (en) 2011-09-13 2016-09-28 药品循环有限责任公司 Combination formulations of histone deacetylase inhibitor and bendamustine and application thereof
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
US20150283159A1 (en) * 2012-11-01 2015-10-08 Microbial Chemistry Research Foundation Anticancer agent, and combination use anticancer agent
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
CN116327887B (en) * 2023-04-24 2023-11-03 南京捷因诊断技术有限公司 Application of LSD1 inhibitor as antitumor drug

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Also Published As

Publication number Publication date
PL2263694T3 (en) 2013-11-29
EP1670514A2 (en) 2006-06-21
MXPA06003222A (en) 2006-05-22
ES2344899T3 (en) 2010-09-09
EP1670514B1 (en) 2010-06-23
CA2540108A1 (en) 2005-04-07
JP4779971B2 (en) 2011-09-28
EP2263694B1 (en) 2013-06-12
US20050070467A1 (en) 2005-03-31
WO2005030239A2 (en) 2005-04-07
DK2263694T3 (en) 2013-08-26
EP2263694A1 (en) 2010-12-22
ATE471740T1 (en) 2010-07-15
PT2263694E (en) 2013-08-27
SI2263694T1 (en) 2013-09-30
CY1114359T1 (en) 2016-08-31
PL1670514T3 (en) 2010-11-30
WO2005030239A3 (en) 2005-07-28
US7314862B2 (en) 2008-01-01
JP2007506647A (en) 2007-03-22
ES2425083T3 (en) 2013-10-11

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