DE602004017658D1 - Therapeutic agents suitable for the treatment of pain - Google Patents

Therapeutic agents suitable for the treatment of pain

Info

Publication number
DE602004017658D1
DE602004017658D1 DE602004017658T DE602004017658T DE602004017658D1 DE 602004017658 D1 DE602004017658 D1 DE 602004017658D1 DE 602004017658 T DE602004017658 T DE 602004017658T DE 602004017658 T DE602004017658 T DE 602004017658T DE 602004017658 D1 DE602004017658 D1 DE 602004017658D1
Authority
DE
Germany
Prior art keywords
pain
treatment
therapeutic agents
agents suitable
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004017658T
Other languages
German (de)
Inventor
Donald J Kyle
Qun Sun
Laykea Tafesse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of DE602004017658D1 publication Critical patent/DE602004017658D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602004017658T 2003-06-12 2004-06-14 Therapeutic agents suitable for the treatment of pain Expired - Lifetime DE602004017658D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47774403P 2003-06-12 2003-06-12

Publications (1)

Publication Number Publication Date
DE602004017658D1 true DE602004017658D1 (en) 2008-12-18

Family

ID=34061917

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602004017658T Expired - Lifetime DE602004017658D1 (en) 2003-06-12 2004-06-14 Therapeutic agents suitable for the treatment of pain
DE602004008069T Expired - Lifetime DE602004008069D1 (en) 2003-06-12 2004-06-14 THERAPEUTIC AGENTS SUITABLE FOR THE TREATMENT OF PAIN

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE602004008069T Expired - Lifetime DE602004008069D1 (en) 2003-06-12 2004-06-14 THERAPEUTIC AGENTS SUITABLE FOR THE TREATMENT OF PAIN

Country Status (28)

Country Link
US (3) US7683063B2 (en)
EP (3) EP1631285B1 (en)
JP (2) JP5269315B2 (en)
KR (2) KR100896497B1 (en)
CN (2) CN1835751B (en)
AR (1) AR044688A1 (en)
AT (2) ATE369133T1 (en)
AU (1) AU2004255169B2 (en)
BR (1) BRPI0411241A (en)
CA (1) CA2528920C (en)
CY (1) CY1108738T1 (en)
DE (2) DE602004017658D1 (en)
DK (1) DK1862458T3 (en)
EA (1) EA009593B1 (en)
ES (1) ES2317623T3 (en)
GE (1) GEP20084488B (en)
IL (1) IL172418A (en)
IS (1) IS8142A (en)
MA (1) MA27908A1 (en)
MX (1) MXPA05013587A (en)
MY (1) MY142655A (en)
NO (1) NO20060192L (en)
PL (1) PL1862458T3 (en)
PT (1) PT1862458E (en)
SI (1) SI1862458T1 (en)
TW (1) TWI287010B (en)
WO (1) WO2005004866A1 (en)
ZA (1) ZA200508744B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100777169B1 (en) 2001-01-29 2007-11-16 시오노기세이야쿠가부시키가이샤 Medicinal preparation containing 5-methyl-1-phenyl-2-1h-pyridone as active ingredient
CA2526361C (en) 2003-05-20 2012-05-15 Ajinomoto Co., Inc. Amide derivative
MY142655A (en) * 2003-06-12 2010-12-15 Euro Celtique Sa Therapeutic agents useful for treating pain
US20050009841A1 (en) * 2003-07-11 2005-01-13 Zheng Guo Zhu Novel amides useful for treating pain
BRPI0412808A (en) * 2003-07-24 2006-09-26 Euro Celtique Sa piperidine compounds and pharmaceutical compositions containing them
DK1867644T3 (en) 2003-07-24 2009-09-21 Euro Celtique Sa Heteroberl-tetrahydropyridyl compounds useful for treating or preventing pain
TW200738232A (en) * 2006-01-31 2007-10-16 Alcon Mfg Ltd Use of vanilloid receptor-1 antagonists for the prevention and treatment of glaucoma
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
KR100801278B1 (en) * 2006-08-29 2008-02-04 삼성전기주식회사 Hybrid type waveguide sensor
US7645767B2 (en) * 2006-08-31 2010-01-12 Trinity Laboratories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
WO2008057300A2 (en) * 2006-10-27 2008-05-15 Redpoint Bio Corporation Trpvi antagonists and uses thereof
MY148657A (en) * 2007-04-27 2013-05-15 Purdue Pharma Lp Trpv1 antagonists and uses thereof
NZ579820A (en) * 2007-04-27 2011-01-28 Purdue Pharma Lp Therapeutic agents useful for treating pain
JP4657384B2 (en) 2007-05-03 2011-03-23 ファイザー・リミテッド 2-pyridinecarboxamide derivatives as sodium channel modulators
US7998982B2 (en) 2007-08-09 2011-08-16 Abbott Laboratories Amide derivatives as TRPV1 antagonists
US8084616B2 (en) 2007-10-24 2011-12-27 Abbott Laboratories TRPV1 antagonists
WO2010000763A2 (en) * 2008-06-30 2010-01-07 Novartis Ag Combination products
EP2585446A4 (en) 2010-06-22 2013-12-25 Shionogi & Co Compounds having trpv1 antagonistic activity and uses thereof
WO2012158844A1 (en) 2011-05-17 2012-11-22 Shionogi & Co., Ltd. Heterocyclic compounds
ME02609B (en) 2011-06-22 2017-06-20 Purdue Pharma Lp Trpv1 antagonists including dihydroxy substituent and uses thereof
WO2013146970A1 (en) * 2012-03-29 2013-10-03 第一三共株式会社 Novel quinoline derivative
TW201730188A (en) * 2015-11-30 2017-09-01 阿斯特捷利康公司 1,3,4-thiadiazole compounds and their use in treating cancer
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
TWI808055B (en) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-1 inhibitors
TWI794171B (en) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-l1 inhibitors
MX2018015170A (en) * 2016-06-23 2019-07-04 St Jude Childrens Res Hospital Small molecule modulators of pantothenate kinases.
MA45780A (en) 2016-07-29 2019-06-05 Janssen Pharmaceutica Nv TREATMENT METHODS FOR PROSTATE CANCER
GB201709459D0 (en) * 2017-06-14 2017-07-26 Intrabio Ltd Treatment for migraine
JP6964506B2 (en) * 2017-12-19 2021-11-10 ライオン株式会社 Tablets and method of manufacturing tablets
US11891378B2 (en) 2017-12-27 2024-02-06 St. Jude Children's Research Hospital, Inc. Small molecule modulators of pantothenate kinases
EP3731859A4 (en) 2017-12-27 2021-09-22 St. Jude Children's Research Hospital, Inc. Methods of treating disorders associated with castor
RU2744162C1 (en) * 2020-03-18 2021-03-03 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России) Analgesic agent based on 5-(2-aminopropyl)-6-oxo-3,4-diphenylpyrrolo[3,4-c]pyrazole
CN113061593B (en) * 2021-04-02 2023-11-10 洛阳华荣生物技术有限公司 L-malate dehydrogenase mutant and application thereof
DE102022104759A1 (en) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-crystal screening method, in particular for the production of co-crystals
CN114957214A (en) * 2022-06-22 2022-08-30 九江善水科技股份有限公司 Preparation method of chlorantraniliprole intermediate

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) * 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
GB1363215A (en) * 1973-01-04 1974-08-14 Mullard Ltd Mechanical-electrical transducer
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US5053595A (en) * 1982-12-01 1991-10-01 Metcal, Inc. Heat shrink sleeve with high mu material
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
JPH0680054B2 (en) 1985-06-19 1994-10-12 吉富製薬株式会社 Piperidine derivative
US5316759A (en) * 1986-03-17 1994-05-31 Robert J. Schaap Agonist-antagonist combination to reduce the use of nicotine and other drugs
DE3822792C2 (en) * 1987-07-11 1997-11-27 Sandoz Ag New use of 5HT¶3¶ antagonists
US5198459A (en) * 1987-07-11 1993-03-30 Sandoz Ltd. Use of 5HT-3 antagonists in preventing or reducing dependency on dependency-inducing agents
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (en) 1989-03-22 1991-07-25 Bioresearch Spa USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS.
US5120548A (en) * 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5075341A (en) * 1989-12-01 1991-12-24 The Mclean Hospital Corporation Treatment for cocaine abuse
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
SI21560B (en) * 1990-06-07 2005-04-30 Astrazeneca Ab 3,5-disubstituted indole derivatives as "5-ht1-similar" receptor agonist1
FR2676734B1 (en) * 1991-05-23 1995-05-19 Roussel Uclaf NEW PYRIMIDINE DERIVATIVES, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5698155A (en) * 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US6204284B1 (en) * 1991-12-20 2001-03-20 American Cyanamid Company Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5232934A (en) * 1992-07-17 1993-08-03 Warner-Lambert Co. Method for the treatment of psychomotor stimulant addiction
DE4234295A1 (en) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carboxylic acid derivatives, medicaments containing these compounds and process for their preparation
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
IT1270594B (en) * 1994-07-07 1997-05-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN
US5556837A (en) * 1994-08-01 1996-09-17 Regeneron Pharmaceuticals Inc. Methods for treating addictive disorders
US5762925A (en) * 1994-11-03 1998-06-09 Sagen; Jacqueline Preventing opiate tolerance by cellular implantation
ATE301457T1 (en) * 1995-06-12 2005-08-15 Searle & Co AGENT CONTAINING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
CA2274593A1 (en) * 1996-12-13 1998-06-18 Banyu Pharmaceutical Co., Ltd. Novel aminopyrazole derivatives
US6703362B1 (en) * 1997-05-15 2004-03-09 Cytogen Corporation Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
JP4444493B2 (en) * 1997-08-20 2010-03-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Nucleic acid sequences encoding capsaicin receptors and capsaicin receptor related polypeptides and uses thereof
EP0943683A1 (en) * 1998-03-10 1999-09-22 Smithkline Beecham Plc Human vanilloid receptor homologue Vanilrep1
US6098369A (en) * 1998-07-17 2000-08-08 Bodolay; William A. Apparatus for attaching a reclosable fastener to a flexible material
US6689780B1 (en) * 1998-12-23 2004-02-10 Eli Lilly And Company Heteroroaromatic amides as inhibitor of factor Xa
WO2000039117A1 (en) * 1998-12-23 2000-07-06 Eli Lilly And Company HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa
WO2000039118A1 (en) * 1998-12-23 2000-07-06 Eli Lilly And Company Aromatic amides
GB9907097D0 (en) * 1999-03-26 1999-05-19 Novartis Ag Organic compounds
US6632815B2 (en) * 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
DE50114170D1 (en) 2000-03-27 2008-09-11 Abbott Gmbh & Co Kg DOPAMINE D3 RECEPTOR LIGANDS FOR THE TREATMENT OF SEARCH
EP1285651B1 (en) * 2000-04-28 2010-09-01 Takeda Pharmaceutical Company Limited Melanin concentrating hormone antagonists
AR028782A1 (en) 2000-07-05 2003-05-21 Taisho Pharmaceutical Co Ltd TETRAHYDROPIRIDINE OR PIPERIDINE HETEROCICLIC DERIVATIVES
JP2003142681A (en) 2001-10-31 2003-05-16 Sony Corp Semiconductor device with insulated gate field effect transistor
JP2003192673A (en) 2001-12-27 2003-07-09 Bayer Ag Piperazinecarboxamide derivative
ES2345044T3 (en) 2002-02-01 2010-09-14 Euro-Celtique S.A. 2-PIPERAZIN-PIRIDINES USEFUL TO TREAT THE PAIN.
DE60325025D1 (en) 2002-02-15 2009-01-15 Glaxo Group Ltd MODULATORS OF THE VANILLOID RECEPTOR
JP2006505570A (en) * 2002-10-17 2006-02-16 アムジエン・インコーポレーテツド Benzimidazole derivatives and their use as vanilloid receptor ligands
US7067509B2 (en) * 2003-03-07 2006-06-27 Neurocrine Biosciences, Inc. Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
US20050014753A1 (en) 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
CA2526361C (en) 2003-05-20 2012-05-15 Ajinomoto Co., Inc. Amide derivative
MY142655A (en) 2003-06-12 2010-12-15 Euro Celtique Sa Therapeutic agents useful for treating pain
US7129235B2 (en) * 2003-07-11 2006-10-31 Abbott Laboratories Amides useful for treating pain
US20050009841A1 (en) * 2003-07-11 2005-01-13 Zheng Guo Zhu Novel amides useful for treating pain
BRPI0412808A (en) * 2003-07-24 2006-09-26 Euro Celtique Sa piperidine compounds and pharmaceutical compositions containing them
DK1867644T3 (en) * 2003-07-24 2009-09-21 Euro Celtique Sa Heteroberl-tetrahydropyridyl compounds useful for treating or preventing pain
NZ579820A (en) * 2007-04-27 2011-01-28 Purdue Pharma Lp Therapeutic agents useful for treating pain

Also Published As

Publication number Publication date
IS8142A (en) 2005-11-23
JP2012021000A (en) 2012-02-02
IL172418A0 (en) 2006-04-10
EP1862458B1 (en) 2008-11-05
CN101863877A (en) 2010-10-20
IL172418A (en) 2011-03-31
MA27908A1 (en) 2006-05-02
US8227467B2 (en) 2012-07-24
ATE413385T1 (en) 2008-11-15
CN1835751B (en) 2010-06-23
PL1862458T3 (en) 2009-04-30
NO20060192L (en) 2006-02-07
CA2528920A1 (en) 2005-01-20
US20130012541A1 (en) 2013-01-10
KR20090008439A (en) 2009-01-21
EP1631285B1 (en) 2007-08-08
ZA200508744B (en) 2006-08-30
JP2007504284A (en) 2007-03-01
JP5269315B2 (en) 2013-08-21
PT1862458E (en) 2009-01-20
AU2004255169A1 (en) 2005-01-20
MXPA05013587A (en) 2006-03-17
EP2060260A1 (en) 2009-05-20
EA009593B1 (en) 2008-02-28
TW200508216A (en) 2005-03-01
EP1862458A3 (en) 2008-01-23
CN1835751A (en) 2006-09-20
EA200501820A1 (en) 2006-06-30
DE602004008069D1 (en) 2007-09-20
BRPI0411241A (en) 2006-07-25
MY142655A (en) 2010-12-15
KR20060012026A (en) 2006-02-06
EP1631285A1 (en) 2006-03-08
US8680118B2 (en) 2014-03-25
KR100896497B1 (en) 2009-05-08
US20110152324A1 (en) 2011-06-23
SI1862458T1 (en) 2009-04-30
US7683063B2 (en) 2010-03-23
GEP20084488B (en) 2008-09-25
AR044688A1 (en) 2005-09-21
EP1631285A4 (en) 2006-11-02
WO2005004866A1 (en) 2005-01-20
CA2528920C (en) 2011-05-03
EP1862458A2 (en) 2007-12-05
TWI287010B (en) 2007-09-21
DK1862458T3 (en) 2009-02-16
CY1108738T1 (en) 2014-07-02
US20070027159A1 (en) 2007-02-01
ES2317623T3 (en) 2009-04-16
AU2004255169B2 (en) 2010-08-26
ATE369133T1 (en) 2007-08-15

Similar Documents

Publication Publication Date Title
ATE413385T1 (en) THERAPEUTIC AGENTS SUITABLE FOR THE TREATMENT OF PAIN
ATE512163T1 (en) ADMINISTRATION OF AGENTS FOR THE TREATMENT OF INFLAMMATION
DE602004028763D1 (en) TE FOR THE TREATMENT OF VIRUS DISEASES
DE60327622D1 (en) COMBINED ANTITACHYCARDIA - PACEMAKERS AND HIGH VOLTAGE THERAPY FOR THE TREATMENT OF VENTRICULAR ARRHYTHMIES
DE60322582D1 (en) SURFACE TREATMENT OF MEDICAL DEVICE
DE60322451D1 (en) 4-tetrazolyl-4-phenylpiperidine derivatives for the treatment of pain
ATE440866T1 (en) NOGO-A-NEUTRALIZING IMMUNOLOBULINES FOR THE TREATMENT OF NEUROLOGICAL DISEASES
DE60335293D1 (en) PYRROLOPYRIDAZINE COMPOUNDS AND USE METHOD FOR THE TREATMENT OF PROLIFERATIVE DISEASES
DE60328476D1 (en) MEDICAL BALLOON SYSTEM FOR THE TREATMENT OF ADIPOSITAS
DE60124302D1 (en) THIAZONE DERIVATIVES FOR THE TREATMENT OF PPAR-LIFE DISEASES
ATE308997T1 (en) AGENTS FOR THE TREATMENT OF DISEASES OF THE ESOPHAUS
DE602004010407D1 (en) FLUORO-SUBSTITUTED OMEGA-CARBOXYARYLDIPHENYL-UREA FOR THE TREATMENT AND PREVENTION OF DISEASES AND SUFFERING
NO20063443L (en) Piperzines effective for treating pain
ATE443704T1 (en) PYRIDOPYRIMIDINONE FOR THE TREATMENT OF CANCER DISEASES
DE60136477D1 (en) RETINOIDES FOR THE TREATMENT OF EMPHYSEM
DE60204466D1 (en) INTEGRINMA TREATMENT FOR THE TREATMENT OF EYE DISEASES
DE602005016141D1 (en) S-MIRTAZAPINE FOR THE TREATMENT OF HITZEWALLUNGEN
DE60236743D1 (en) FOR THE TREATMENT OF ANDROGEN-DEPENDENT DISEASES
DE60238765D1 (en) CARBAMATE COMPOUNDS FOR THE TREATMENT OF PAIN
DE60127552D1 (en) INTRAKORPORAL MEDICAMENTS FOR HIGH-ENERGETIC PHOTOTHERAPEUTIC TREATMENT OF DISEASES
ATE482707T1 (en) 1-Ä2H-1-BENZOPYRAN-2-ON-8-YLÜ-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN
DE602005015434D1 (en) MEANS FOR THE TREATMENT OF PSYCHONEUROTIC DISEASES
DE60016047D1 (en) DIHYDROBENZOPYRANE, DIHYDROBENZOTHIOPYRANE AND TETRAHYDROCHINOLINE FOR THE TREATMENT OF COX-2-DEPENDENT DISEASES
DE60315490D1 (en) THERAPEUTIC TREATMENT
DE60223707D1 (en) CALCIUM-L-THREONATE FOR THE TREATMENT OF BONE FRACTURES

Legal Events

Date Code Title Description
8364 No opposition during term of opposition