DE602004013021D1 - Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung - Google Patents

Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung

Info

Publication number
DE602004013021D1
DE602004013021D1 DE602004013021T DE602004013021T DE602004013021D1 DE 602004013021 D1 DE602004013021 D1 DE 602004013021D1 DE 602004013021 T DE602004013021 T DE 602004013021T DE 602004013021 T DE602004013021 T DE 602004013021T DE 602004013021 D1 DE602004013021 D1 DE 602004013021D1
Authority
DE
Germany
Prior art keywords
preparation
months
api
alpha
large scale
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004013021T
Other languages
English (en)
Other versions
DE602004013021T3 (de
DE602004013021T2 (de
Inventor
Shabtai Bauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kamada Ltd
Original Assignee
Kamada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34379546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602004013021(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IL15805303A external-priority patent/IL158053A0/xx
Application filed by Kamada Ltd filed Critical Kamada Ltd
Publication of DE602004013021D1 publication Critical patent/DE602004013021D1/de
Application granted granted Critical
Publication of DE602004013021T2 publication Critical patent/DE602004013021T2/de
Publication of DE602004013021T3 publication Critical patent/DE602004013021T3/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE602004013021T 2003-09-22 2004-09-22 Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung Active DE602004013021T3 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US50390203P 2003-09-22 2003-09-22
IL15805303 2003-09-22
IL15805303A IL158053A0 (en) 2003-09-22 2003-09-22 Process for large scale purification of alpha-1 proteinase inhibitor
US503902P 2003-09-22
PCT/IL2004/000881 WO2005027821A2 (en) 2003-09-22 2004-09-22 Large scale preparation of alpha-1 proteinase inhibitor and use thereof
EP04770552A EP1664123B2 (de) 2003-09-22 2004-09-22 Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung

Publications (3)

Publication Number Publication Date
DE602004013021D1 true DE602004013021D1 (de) 2008-05-21
DE602004013021T2 DE602004013021T2 (de) 2009-06-25
DE602004013021T3 DE602004013021T3 (de) 2012-04-05

Family

ID=34379546

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004013021T Active DE602004013021T3 (de) 2003-09-22 2004-09-22 Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung

Country Status (12)

Country Link
US (2) US7879800B2 (de)
EP (1) EP1664123B2 (de)
AT (1) ATE391730T1 (de)
CA (1) CA2538998C (de)
DE (1) DE602004013021T3 (de)
DK (1) DK1664123T4 (de)
ES (1) ES2305845T5 (de)
IL (1) IL174410A0 (de)
PL (1) PL1664123T5 (de)
PT (1) PT1664123E (de)
SI (1) SI1664123T2 (de)
WO (1) WO2005027821A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0524432D0 (en) 2005-11-30 2006-01-11 Nhs Blood & Transplant Method
CA2641872A1 (en) 2006-02-09 2007-08-16 Kamada Ltd. Alpha-i antitrypsin for treating exacerbation episodes of pulmonary diseases
CN103396479A (zh) 2007-08-17 2013-11-20 Csl百灵有限公司 α-1-抗胰蛋白酶和载脂蛋白A-I的纯化方法
CN102099369A (zh) * 2008-07-18 2011-06-15 泰勒克里斯生物治疗学公司 制备α-1蛋白酶抑制剂的方法
EP2496246B1 (de) 2009-11-03 2018-06-27 Grifols Therapeutics LLC Zusammensetzung, verfahren und kit für einen alpha-1-proteasehmmer
CA2781120C (en) 2009-11-24 2015-01-27 Jianxin Guo Lyophilization methods, compositions, and kits
EP3412314A1 (de) 2011-05-27 2018-12-12 Baxalta GmbH Mit polysialsäure konjugierte therapeutische proteine und verfahren zur herstellung davon
MY166314A (en) 2011-12-30 2018-06-25 Grifols Sa Alpha1-proteinase inhibitor for delaying the onset or progression of pulmonary exacerbations
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
US9353165B2 (en) 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
IL267520B2 (en) * 2016-12-22 2023-09-01 Kamada Ltd Dry powder composition of alpha-1 antitrypsin
US10960062B2 (en) 2017-02-21 2021-03-30 Kamada Ltd. Methods and uses of alpha 1-antitrypsin for early intervention in pulmonary diseases
EP3723790B1 (de) 2017-12-12 2024-03-13 Kamada Ltd Verfahren zur induzierung der immuntoleranz und zur verminderung der antiinflammatorischen antikörperreaktion
IL267923B2 (en) 2018-08-02 2023-06-01 Grifols Worldwide Operations Ltd The composition containing the most concentrated alpha-1 type protein inhibitor and a method for obtaining it
WO2020157752A1 (en) * 2019-01-29 2020-08-06 Kamada Ltd Pharmaceutical aerosol composition

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439358A (en) 1982-06-17 1984-03-27 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4379087A (en) 1982-06-17 1983-04-05 Cutter Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4683294A (en) 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
US4697003A (en) * 1985-11-01 1987-09-29 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4656254A (en) 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
US4629567A (en) 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
US4749783A (en) 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
US5114917A (en) 1986-12-24 1992-05-19 John Lezdey Treatment of inflammation using alpha 1-antichymotrypsin
ATE178094T1 (de) 1990-05-01 1999-04-15 Chiron Corp Interleukin-i antagonist und seine verwendung
US5814225A (en) 1994-06-09 1998-09-29 Shanbrom Technologies Llc Iodinated gel filtration media for disinfecting protein solutions
US6284874B1 (en) 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
EP0871671A1 (de) 1995-09-07 1998-10-21 PPL Therapeutics (Scotland) Limited Reinigung von alpha-1 proteininhibitoren
US5780440A (en) 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
TW491855B (en) * 1996-08-07 2002-06-21 Csl Ltd Purification of immunoglobulins
AT407114B (de) 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung
US6093804A (en) † 1998-09-24 2000-07-25 American National Red Cross Method for purification of alpha-1 proteinase inhibitor
US6462180B1 (en) * 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
EP1343809B2 (de) 2000-12-14 2023-03-15 Grifols Therapeutics Inc. Verfahren zur herstellung eines alpha-1-proteinaseinhibitors
US7323553B2 (en) 2002-04-26 2008-01-29 Genentech, Inc. Non-affinity purification of proteins
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
RS20060077A (en) 2003-08-12 2008-08-07 Octapharma Ag., Process for preparing an alpha-1-antitrypsin solution
EP1765866B1 (de) 2004-06-07 2014-01-08 Therapure Biopharma Inc. Isolierung von plasma- oder serumprotein

Also Published As

Publication number Publication date
ES2305845T3 (es) 2008-11-01
DE602004013021T3 (de) 2012-04-05
DE602004013021T2 (de) 2009-06-25
EP1664123A2 (de) 2006-06-07
SI1664123T2 (sl) 2012-03-30
ES2305845T5 (es) 2012-04-12
ATE391730T1 (de) 2008-04-15
DK1664123T3 (da) 2008-07-28
IL174410A0 (en) 2006-08-01
PL1664123T5 (pl) 2012-04-30
EP1664123A4 (de) 2006-11-02
CA2538998C (en) 2015-11-24
WO2005027821A2 (en) 2005-03-31
WO2005027821A3 (en) 2005-08-04
DK1664123T4 (da) 2012-03-05
US20110092444A1 (en) 2011-04-21
PL1664123T3 (pl) 2008-11-28
AU2004273696A1 (en) 2005-03-31
SI1664123T1 (sl) 2008-10-31
CA2538998A1 (en) 2005-03-31
US20080139465A1 (en) 2008-06-12
EP1664123B2 (de) 2011-11-30
EP1664123B1 (de) 2008-04-09
US7879800B2 (en) 2011-02-01
PT1664123E (pt) 2008-07-16

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