DE602004004774D1 - Verfahren zur selektion allosterischer modulatoren von g-protein gekoppelten rezeptoren der familie iii - Google Patents
Verfahren zur selektion allosterischer modulatoren von g-protein gekoppelten rezeptoren der familie iiiInfo
- Publication number
- DE602004004774D1 DE602004004774D1 DE602004004774T DE602004004774T DE602004004774D1 DE 602004004774 D1 DE602004004774 D1 DE 602004004774D1 DE 602004004774 T DE602004004774 T DE 602004004774T DE 602004004774 T DE602004004774 T DE 602004004774T DE 602004004774 D1 DE602004004774 D1 DE 602004004774D1
- Authority
- DE
- Germany
- Prior art keywords
- iii
- receptor
- selection
- rcpg
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003281 allosteric effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 6
- 108020003175 receptors Proteins 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 108091006027 G proteins Proteins 0.000 abstract 3
- 102000030782 GTP binding Human genes 0.000 abstract 3
- 108091000058 GTP-Binding Proteins 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000921 anthelmintic agent Substances 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000002917 insecticide Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0306136A FR2855270A1 (fr) | 2003-05-22 | 2003-05-22 | Procede de selection de regulateurs allosteriques des recepteurs couples aux proteines g de classe iii |
| FR0306136 | 2003-05-22 | ||
| PCT/FR2004/001140 WO2004106932A1 (fr) | 2003-05-22 | 2004-05-11 | Procede de selection de regulateurs allosteriques des recepteurs couples aux proteines g de classe iii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004004774D1 true DE602004004774D1 (de) | 2007-03-29 |
| DE602004004774T2 DE602004004774T2 (de) | 2007-11-22 |
Family
ID=33396655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004004774T Expired - Lifetime DE602004004774T2 (de) | 2003-05-22 | 2004-05-11 | Verfahren zur selektion allosterischer modulatoren von g-protein gekoppelten rezeptoren der familie iii |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7611848B2 (de) |
| EP (1) | EP1625400B1 (de) |
| JP (1) | JP4739193B2 (de) |
| AT (1) | ATE354092T1 (de) |
| CA (1) | CA2526695C (de) |
| DE (1) | DE602004004774T2 (de) |
| FR (1) | FR2855270A1 (de) |
| WO (1) | WO2004106932A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013022948A1 (en) | 2011-08-08 | 2013-02-14 | The Coca-Cola Company | Cell lines comprising endogenous taste receptors and their uses |
| WO2013067519A2 (en) * | 2011-11-04 | 2013-05-10 | Purdue Research Foundation | Insect and tick g-coupled receptors useful as targets for insecticides and compounds and reagents identified using the same |
| CN114763560B (zh) * | 2021-09-30 | 2023-03-24 | 生物岛实验室 | 表达代谢型谷氨酸受体2和g蛋白嵌合体的细胞株 |
-
2003
- 2003-05-22 FR FR0306136A patent/FR2855270A1/fr not_active Withdrawn
-
2004
- 2004-05-11 DE DE602004004774T patent/DE602004004774T2/de not_active Expired - Lifetime
- 2004-05-11 JP JP2006516255A patent/JP4739193B2/ja not_active Expired - Fee Related
- 2004-05-11 US US10/557,986 patent/US7611848B2/en not_active Expired - Fee Related
- 2004-05-11 CA CA2526695A patent/CA2526695C/fr not_active Expired - Fee Related
- 2004-05-11 AT AT04742696T patent/ATE354092T1/de not_active IP Right Cessation
- 2004-05-11 WO PCT/FR2004/001140 patent/WO2004106932A1/fr active IP Right Grant
- 2004-05-11 EP EP04742696A patent/EP1625400B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2526695C (fr) | 2013-07-16 |
| US7611848B2 (en) | 2009-11-03 |
| EP1625400A1 (de) | 2006-02-15 |
| CA2526695A1 (fr) | 2004-12-09 |
| WO2004106932A1 (fr) | 2004-12-09 |
| DE602004004774T2 (de) | 2007-11-22 |
| FR2855270A1 (fr) | 2004-11-26 |
| EP1625400B1 (de) | 2007-02-14 |
| ATE354092T1 (de) | 2007-03-15 |
| JP4739193B2 (ja) | 2011-08-03 |
| US20080058430A1 (en) | 2008-03-06 |
| JP2007526878A (ja) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |