DE60142484D1 - CCR3 RECEPTOR ANTAGONISTS - Google Patents

CCR3 RECEPTOR ANTAGONISTS

Info

Publication number
DE60142484D1
DE60142484D1 DE60142484T DE60142484T DE60142484D1 DE 60142484 D1 DE60142484 D1 DE 60142484D1 DE 60142484 T DE60142484 T DE 60142484T DE 60142484 T DE60142484 T DE 60142484T DE 60142484 D1 DE60142484 D1 DE 60142484D1
Authority
DE
Germany
Prior art keywords
sub
sup
alkyl
img
character
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60142484T
Other languages
German (de)
Inventor
Gurdip Bhalay
Trevor John Howe
Grand Darren Mark Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0024675A external-priority patent/GB0024675D0/en
Priority claimed from GB0120549A external-priority patent/GB0120549D0/en
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE60142484D1 publication Critical patent/DE60142484D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compounds of formula (I) in free or salt form, where Ar<SUP>1 </SUP>is phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C<SUB>1</SUB>-C<SUB>8</SUB>-alkyl optionally substituted by cyano or halogen, Ar<SUP>2 </SUP>is phenyl optionally which is unsubstituted or substituted by one or more substituents selected from halogen, cyano, hydroxy, nitro, C<SUB>1</SUB>-C<SUB>8</SUB>-alkyl, C<SUB>1</SUB>-C<SUB>8</SUB>-haloalkyl, C<SUB>1</SUB>-C<SUB>8</SUB>-alkoxy or C<SUB>1</SUB>-C<SUB>8</SUB>-alkoxycarbonyl, R<SUP>1 </SUP>is C<SUB>1</SUB>-C<SUB>8</SUB>-alkyl substituted by hydroxy, C<SUB>1</SUB>-C<SUB>8</SUB>-alkoxy, acyloxy, -N(R<SUP>2</SUP>)R<SUP>3</SUP>, halogen, carboxy, C<SUB>1</SUB>-C<SUB>8</SUB>-alkoxycarbonyl, phenyl-C<SUB>1</SUB>-C<SUB>8</SUB>-alkoxycarbonyl, -CON(R<SUP>4</SUP>)R<SUP>5 </SUP>or by a monovalent cyclic organic group, R<SUP>2 </SUP>and R?3 <img id="CUSTOM-CHARACTER-00001" he="2.12mm" wi="1.44mm" file="US07034042-20060425-P00001.TIF" alt="custom character" img-content="character" img-format="tif"/> are each independently hydrogen or C<SUB>1</SUB>-C<SUB>8</SUB>-alkyl, or R<SUP>2 </SUP>is hydrogen and R<SUP>3 </SUP>is acyl or SO<SUB>2</SUB>R<SUP>6</SUP>, or R<SUP>2 </SUP>and R<SUP>3 </SUP>together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R<SUP>4 </SUP>and R<SUP>5 </SUP>are each independently hydrogen, C<SUB>1</SUB>-C<SUB>8</SUB>-alkyl optionally substituted by hydroxy or phenyl, or phenyl optionally substituted by C<SUB>1</SUB>-C<SUB>8</SUB>-alkyl, halogen, cyano or C<SUB>1</SUB>-C<SUB>8</SUB>-alkoxy, or R<SUP>4 </SUP>and R<SUP>5 </SUP>together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R?6 <img id="CUSTOM-CHARACTER-00002" he="2.12mm" wi="1.44mm" file="US07034042-20060425-P00002.TIF" alt="custom character" img-content="character" img-format="tif"/> is C<SUB>1</SUB>-C<SUB>8</SUB>-alkyl, C<SUB>1</SUB>-C<SUB>8</SUB>-haloalkyl, or phenyl optionally substituted by C<SUB>1</SUB>-C<SUB>8</SUB>-alkyl, and n is 1, 2, 3 or 4. The compounds are useful as pharmaceuticals.
DE60142484T 2000-10-09 2001-10-08 CCR3 RECEPTOR ANTAGONISTS Expired - Lifetime DE60142484D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0024675A GB0024675D0 (en) 2000-10-09 2000-10-09 Organic compounds
GB0120549A GB0120549D0 (en) 2001-08-23 2001-08-23 Organic compounds
PCT/EP2001/011627 WO2002030898A1 (en) 2000-10-09 2001-10-08 N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists

Publications (1)

Publication Number Publication Date
DE60142484D1 true DE60142484D1 (en) 2010-08-12

Family

ID=26245127

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60142484T Expired - Lifetime DE60142484D1 (en) 2000-10-09 2001-10-08 CCR3 RECEPTOR ANTAGONISTS

Country Status (12)

Country Link
US (1) US7034042B2 (en)
EP (1) EP1330436B1 (en)
JP (1) JP4199539B2 (en)
CN (1) CN1209351C (en)
AT (1) ATE472533T1 (en)
AU (1) AU2001295601A1 (en)
BR (1) BR0114485A (en)
CA (1) CA2423296C (en)
DE (1) DE60142484D1 (en)
ES (1) ES2348290T3 (en)
PT (1) PT1330436E (en)
WO (1) WO2002030898A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117387D0 (en) * 2001-07-17 2001-09-05 Novartis Ag Organic compounds
EP1505067A4 (en) * 2002-04-25 2006-06-21 Teijin Ltd 4,4-disubstituted piperidine derivatives having ccr3 antagonism
ZA200803939B (en) * 2005-11-24 2009-10-28 Eisai R&D Man Co Ltd Morpholine type cinnamide compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673684A (en) * 1984-04-04 1987-06-16 Terumo Corporation Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient
JPH0660160B2 (en) * 1985-12-13 1994-08-10 テルモ株式会社 Amide derivative and antiallergic agent containing the same
JPS63139124A (en) * 1986-12-01 1988-06-10 Terumo Corp Remedy for nephritis
JPS63179869A (en) * 1987-01-20 1988-07-23 Dainippon Pharmaceut Co Ltd Piperidine derivative
DE19756235A1 (en) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New piperidinyl-substituted pyridylalkane alkene and alkane carboxylic acid amides
EE200100502A (en) 1999-03-26 2002-12-16 Astrazeneca Ab Compounds
TWI227231B (en) * 2000-07-12 2005-02-01 Novartis Ag 4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3

Also Published As

Publication number Publication date
US20040087621A1 (en) 2004-05-06
ATE472533T1 (en) 2010-07-15
PT1330436E (en) 2010-10-11
ES2348290T3 (en) 2010-12-02
EP1330436A1 (en) 2003-07-30
CN1468222A (en) 2004-01-14
CA2423296C (en) 2009-12-29
AU2001295601A1 (en) 2002-04-22
JP4199539B2 (en) 2008-12-17
US7034042B2 (en) 2006-04-25
CN1209351C (en) 2005-07-06
CA2423296A1 (en) 2002-04-18
BR0114485A (en) 2003-11-18
EP1330436B1 (en) 2010-06-30
JP2004511467A (en) 2004-04-15
WO2002030898A1 (en) 2002-04-18

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN