DE60140373D1 - FERMENTATION METHOD FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS FROM THE FAMILY OF THE ENTEROBACTERIACEAE - Google Patents
FERMENTATION METHOD FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS FROM THE FAMILY OF THE ENTEROBACTERIACEAEInfo
- Publication number
- DE60140373D1 DE60140373D1 DE60140373T DE60140373T DE60140373D1 DE 60140373 D1 DE60140373 D1 DE 60140373D1 DE 60140373 T DE60140373 T DE 60140373T DE 60140373 T DE60140373 T DE 60140373T DE 60140373 D1 DE60140373 D1 DE 60140373D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- amino acids
- family
- enterobacteriaceae
- strains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The invention relates to a fermentation process for the preparation of L-amino acids, especially L-threonine, in which the following steps are carried out: a) fermentation of the microorganisms of the family Enterobacteriaceae producing the desired L-amino acid, in which microorganisms at least the pckA gene and/or the open reading frames yjfA and ytfP are, individually or jointly, attenuated and, in particular, switched off, b) enrichment of the L-amino acid in the medium or in the bacterial cells, and c) isolation of the L-amino acid.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10048605 | 2000-09-30 | ||
DE10055516 | 2000-11-09 | ||
DE10130192A DE10130192A1 (en) | 2000-09-30 | 2001-06-22 | Process for the fermentative production of L-amino acids using strains of the Enterobacteriaceae family |
PCT/EP2001/010209 WO2002029080A2 (en) | 2000-09-30 | 2001-09-05 | Fermentation process for the preparation of l-amino acids using strains of the family enterobacteriaceae |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60140373D1 true DE60140373D1 (en) | 2009-12-17 |
Family
ID=26007228
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10130192A Withdrawn DE10130192A1 (en) | 2000-09-30 | 2001-06-22 | Process for the fermentative production of L-amino acids using strains of the Enterobacteriaceae family |
DE60140373T Expired - Lifetime DE60140373D1 (en) | 2000-09-30 | 2001-09-05 | FERMENTATION METHOD FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS FROM THE FAMILY OF THE ENTEROBACTERIACEAE |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10130192A Withdrawn DE10130192A1 (en) | 2000-09-30 | 2001-06-22 | Process for the fermentative production of L-amino acids using strains of the Enterobacteriaceae family |
Country Status (6)
Country | Link |
---|---|
AT (1) | ATE447618T1 (en) |
DE (2) | DE10130192A1 (en) |
DK (1) | DK1320626T3 (en) |
ES (1) | ES2336192T3 (en) |
PL (1) | PL210791B1 (en) |
PT (1) | PT1320626E (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10147960A1 (en) * | 2001-09-28 | 2003-04-10 | Degussa | Process for the fermentative production of D-pantothenic acid and / or its salts |
US20190276859A1 (en) * | 2016-07-08 | 2019-09-12 | Evonik Degussa Gmbh | Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts) |
-
2001
- 2001-06-22 DE DE10130192A patent/DE10130192A1/en not_active Withdrawn
- 2001-09-05 AT AT01974228T patent/ATE447618T1/en active
- 2001-09-05 DK DK01974228.7T patent/DK1320626T3/en active
- 2001-09-05 PT PT01974228T patent/PT1320626E/en unknown
- 2001-09-05 DE DE60140373T patent/DE60140373D1/en not_active Expired - Lifetime
- 2001-09-05 ES ES01974228T patent/ES2336192T3/en not_active Expired - Lifetime
- 2001-09-05 PL PL387772A patent/PL210791B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PT1320626E (en) | 2010-02-02 |
ES2336192T3 (en) | 2010-04-09 |
DE10130192A1 (en) | 2002-04-11 |
PL210791B1 (en) | 2012-03-30 |
ATE447618T1 (en) | 2009-11-15 |
DK1320626T3 (en) | 2010-03-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |