DE60139133D1 - Nicht-menschliches säugetier mit fehlender expression der alpha6 nikotinischen acetylcholin rezeptoruntereinheit und verwendung zum screening - Google Patents

Nicht-menschliches säugetier mit fehlender expression der alpha6 nikotinischen acetylcholin rezeptoruntereinheit und verwendung zum screening

Info

Publication number
DE60139133D1
DE60139133D1 DE60139133T DE60139133T DE60139133D1 DE 60139133 D1 DE60139133 D1 DE 60139133D1 DE 60139133 T DE60139133 T DE 60139133T DE 60139133 T DE60139133 T DE 60139133T DE 60139133 D1 DE60139133 D1 DE 60139133D1
Authority
DE
Germany
Prior art keywords
alpha6
acetylcholine receptor
human
mammali
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60139133T
Other languages
English (en)
Inventor
Nicolas Champtiaux
Jean-Pierre Changeux
Alain Bessis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Pasteur de Lille
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Institut Pasteur de Lille filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of DE60139133D1 publication Critical patent/DE60139133D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60139133T 2000-09-04 2001-09-04 Nicht-menschliches säugetier mit fehlender expression der alpha6 nikotinischen acetylcholin rezeptoruntereinheit und verwendung zum screening Expired - Lifetime DE60139133D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0011247A FR2813499B1 (fr) 2000-09-04 2000-09-04 Mammifere non-humain mutant pour l'expression de la sous- unite alpha6 du recepteur nicotinique de l'acetylcholine et utilisation pour le criblage de substances susceptibles d'interagir avec ce recepteur
PCT/FR2001/002741 WO2002019812A2 (fr) 2000-09-04 2001-09-04 Mammifere non-humain mutant pour l'expression de la sous-unite alpha6 du recepteur nicotinique de l'acetylcholine et utilisation pour le criblage de substances susceptibles d'interagir avec ce recepteur

Publications (1)

Publication Number Publication Date
DE60139133D1 true DE60139133D1 (de) 2009-08-13

Family

ID=8853944

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60139133T Expired - Lifetime DE60139133D1 (de) 2000-09-04 2001-09-04 Nicht-menschliches säugetier mit fehlender expression der alpha6 nikotinischen acetylcholin rezeptoruntereinheit und verwendung zum screening

Country Status (13)

Country Link
US (1) US7820876B2 (de)
EP (1) EP1315417B1 (de)
JP (1) JP2004508817A (de)
AT (1) ATE434932T1 (de)
AU (1) AU2001291929A1 (de)
CA (1) CA2421324A1 (de)
CY (1) CY1110482T1 (de)
DE (1) DE60139133D1 (de)
DK (1) DK1315417T3 (de)
ES (1) ES2329011T3 (de)
FR (1) FR2813499B1 (de)
PT (1) PT1315417E (de)
WO (1) WO2002019812A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1499350A4 (de) 2001-08-31 2006-02-08 Agensys Inc Nukleinsäure und zugehöriges protein mit der bezeichnung 205p1b5 zur verwendung bei der behandlung und zum nachweis von krebs
US20090100532A1 (en) * 2007-09-25 2009-04-16 California Institute Of Technology Transgenic mice expressing hypersensitive nicotinic receptors
JP2013220090A (ja) * 2012-04-19 2013-10-28 Tohoku Univ 眼疾患治療に使用する薬剤スクリーニング方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5683912A (en) * 1994-07-21 1997-11-04 The Salk Institute For Biological Studies Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit
US6485967B1 (en) * 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
DE19850015A1 (de) 1998-10-30 2000-05-04 Max Delbrueck Centrum Proteine der Stomatinfamilie und ihre Verwendung als Zielproteine für die Schm erztherapie
US6252132B1 (en) * 1998-11-02 2001-06-26 Institut Pasteur Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor

Also Published As

Publication number Publication date
US7820876B2 (en) 2010-10-26
PT1315417E (pt) 2009-08-25
ES2329011T3 (es) 2009-11-20
EP1315417A2 (de) 2003-06-04
WO2002019812A3 (fr) 2002-05-02
US20040006782A1 (en) 2004-01-08
FR2813499B1 (fr) 2004-11-26
ATE434932T1 (de) 2009-07-15
JP2004508817A (ja) 2004-03-25
FR2813499A1 (fr) 2002-03-08
CY1110482T1 (el) 2015-04-29
DK1315417T3 (da) 2009-10-19
WO2002019812A2 (fr) 2002-03-14
CA2421324A1 (fr) 2002-03-14
EP1315417B1 (de) 2009-07-01
AU2001291929A1 (en) 2002-03-22

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