DE60126143D1 - GUANIDINE AND AMIDINE COMPOUNDS, AND THEIR USE AS FACTOR XA INHIBITORS - Google Patents

GUANIDINE AND AMIDINE COMPOUNDS, AND THEIR USE AS FACTOR XA INHIBITORS

Info

Publication number
DE60126143D1
DE60126143D1 DE60126143T DE60126143T DE60126143D1 DE 60126143 D1 DE60126143 D1 DE 60126143D1 DE 60126143 T DE60126143 T DE 60126143T DE 60126143 T DE60126143 T DE 60126143T DE 60126143 D1 DE60126143 D1 DE 60126143D1
Authority
DE
Germany
Prior art keywords
guanidine
inhibitors
factor
amidine compounds
amidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60126143T
Other languages
German (de)
Other versions
DE60126143T2 (en
Inventor
Anuschirwan Peyman
William Will
Uwe Gerlach
Marc Nazar
Gerhard Zoller
Hans-Peter Nestler
Hans Matter
Fahad Al-Obeidi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Application granted granted Critical
Publication of DE60126143D1 publication Critical patent/DE60126143D1/en
Publication of DE60126143T2 publication Critical patent/DE60126143T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60126143T 2000-12-06 2001-11-28 GUANIDINE AND AMIDINE COMPOUNDS, AND THEIR USE AS FACTOR XA INHIBITORS Expired - Lifetime DE60126143T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00126750 2000-12-06
EP00126750 2000-12-06
PCT/EP2001/013874 WO2002046159A1 (en) 2000-12-06 2001-11-28 Guanidine and amidine derivatives as factor xa inhibitors

Publications (2)

Publication Number Publication Date
DE60126143D1 true DE60126143D1 (en) 2007-03-08
DE60126143T2 DE60126143T2 (en) 2007-11-15

Family

ID=8170585

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60126143T Expired - Lifetime DE60126143T2 (en) 2000-12-06 2001-11-28 GUANIDINE AND AMIDINE COMPOUNDS, AND THEIR USE AS FACTOR XA INHIBITORS

Country Status (26)

Country Link
US (2) US20020173656A1 (en)
EP (1) EP1345900B1 (en)
JP (1) JP4274522B2 (en)
KR (1) KR20040015036A (en)
CN (1) CN1479722A (en)
AR (1) AR033684A1 (en)
AU (2) AU3320602A (en)
BR (1) BR0115938A (en)
CA (1) CA2430518C (en)
CZ (1) CZ20031554A3 (en)
DE (1) DE60126143T2 (en)
DK (1) DK1345900T3 (en)
EE (1) EE200300192A (en)
ES (1) ES2278798T3 (en)
HR (1) HRP20030447A2 (en)
HU (1) HUP0302604A3 (en)
IL (2) IL156214A0 (en)
MX (1) MXPA03004848A (en)
NO (1) NO20032489L (en)
NZ (1) NZ526269A (en)
PL (1) PL362320A1 (en)
PT (1) PT1345900E (en)
RU (1) RU2003120070A (en)
SK (1) SK6862003A3 (en)
WO (1) WO2002046159A1 (en)
ZA (1) ZA200303847B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005535710A (en) * 2002-08-09 2005-11-24 トランス　テック　ファーマ，インコーポレイテッド Aryl and heteroaryl compounds and methods for modulating coagulation
US7405210B2 (en) 2003-05-21 2008-07-29 Osi Pharmaceuticals, Inc. Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
CA2531796A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014534A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2005034994A1 (en) * 2003-10-10 2005-04-21 Chugai Seiyaku Kabushiki Kaisha Remedy for solid tumor
JP2007527904A (en) 2004-03-08 2007-10-04 プロシディオン・リミテッド Pyrrolopyridine-2-carboxylic acid hydrazide compounds as glycogen phosphorylase inhibitors
WO2006059164A2 (en) 2004-12-02 2006-06-08 Prosidion Limited Pyrrolopyridine-2-carboxylic acid amides
DE102006048300A1 (en) * 2006-01-26 2007-08-02 Hellstern, Peter, Prof. Dr.med. New amidinobenzylamino-peptide derivatives, useful as anticoagulant in ex vivo systems, are inhibitors of activated factor X and other enzymes involved in coagulation
US20100222381A1 (en) 2009-02-27 2010-09-02 Hariprasad Vankayalapati Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
US8507640B2 (en) 2010-08-19 2013-08-13 International Business Machines Corporation Methods of ring opening polymerization and catalysts therefor
JO3407B1 (en) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd Tetrahydropyrazolopyrimidine Compounds
MA49566A (en) 2017-07-11 2020-05-20 Vertex Pharma CARBOXAMIDES USED AS SODIUM CHANNEL INHIBITORS
AU2018346597B2 (en) 2017-10-06 2023-07-13 Forma Therapeutics, Inc. Inhibiting Ubiquitin Specific Peptidase 30
BR112021003620A2 (en) 2018-10-05 2021-05-18 Forma Therapeutics, Inc. Fused pyrrolines that act as specific protease inhibitors for ubiquitin 30 (usp30)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201303B (en) * 1990-07-05 1993-03-01 Hoffmann La Roche
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
ES2103181B1 (en) * 1994-08-01 1998-04-01 Menarini Lab NAFTALENIC AMIDES WITH ANTAGONIST ACTION OF THE LEUKOTRENEES.
SK286094B6 (en) * 1994-04-26 2008-03-05 Aventis Pharmaceuticals Inc. Factor Xa inhibitors, pharmaceutical composition containing the same and its use
US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
TW542822B (en) * 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
US6417200B1 (en) * 1997-06-26 2002-07-09 Eli Lilly And Company Antithrombotic agents
ES2224620T3 (en) * 1998-03-23 2005-03-01 Aventis Pharmaceuticals Inc. DERIVATIVES OF PIPERIDINYL AND N-AMINOPIPERIDINYL.
US20020016339A1 (en) * 1998-03-23 2002-02-07 Klein Scott I. Piperididinyl and N-amidinopiperidinyl derivatives
EP0987274A1 (en) 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
CA2385592C (en) * 1999-09-17 2011-01-11 Bing-Yan Zhu Benzamides and related inhibitors of factor xa

Also Published As

Publication number Publication date
HRP20030447A2 (en) 2005-04-30
CA2430518C (en) 2010-06-15
CA2430518A1 (en) 2002-06-13
BR0115938A (en) 2003-12-23
EP1345900B1 (en) 2007-01-17
RU2003120070A (en) 2004-12-27
US20050143419A1 (en) 2005-06-30
NO20032489D0 (en) 2003-06-02
ZA200303847B (en) 2004-04-15
US7435747B2 (en) 2008-10-14
JP2004515492A (en) 2004-05-27
EE200300192A (en) 2003-08-15
EP1345900A1 (en) 2003-09-24
CZ20031554A3 (en) 2003-08-13
KR20040015036A (en) 2004-02-18
NO20032489L (en) 2003-07-25
AU2002233206B2 (en) 2006-06-22
CN1479722A (en) 2004-03-03
HUP0302604A2 (en) 2003-11-28
US20020173656A1 (en) 2002-11-21
DK1345900T3 (en) 2007-05-21
WO2002046159A1 (en) 2002-06-13
DE60126143T2 (en) 2007-11-15
AU3320602A (en) 2002-06-18
JP4274522B2 (en) 2009-06-10
PT1345900E (en) 2007-03-30
NZ526269A (en) 2004-11-26
PL362320A1 (en) 2004-10-18
MXPA03004848A (en) 2003-08-19
HUP0302604A3 (en) 2005-09-28
SK6862003A3 (en) 2004-02-03
ES2278798T3 (en) 2007-08-16
AR033684A1 (en) 2004-01-07
IL156214A (en) 2010-05-31
IL156214A0 (en) 2003-12-23

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Legal Events

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