DE60102137T2 - BETA-AMINIC ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEASES AND TNA ALPHA INHIBITORS - Google Patents

BETA-AMINIC ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEASES AND TNA ALPHA INHIBITORS Download PDF

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Publication number
DE60102137T2
DE60102137T2 DE60102137T DE60102137T DE60102137T2 DE 60102137 T2 DE60102137 T2 DE 60102137T2 DE 60102137 T DE60102137 T DE 60102137T DE 60102137 T DE60102137 T DE 60102137T DE 60102137 T2 DE60102137 T2 DE 60102137T2
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Prior art keywords
beta
acid derivatives
matrix metalloproteases
alpha inhibitors
aminic acid
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Expired - Lifetime
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DE60102137T
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German (de)
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DE60102137D1 (en
Inventor
Jingwu Duan
W King
Carl Decicco
P Maduskuie
E Voss
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Bristol Myers Squibb Pharma Co
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Bristol Myers Squibb Pharma Co
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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DE60102137T 2000-03-17 2001-03-15 BETA-AMINIC ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEASES AND TNA ALPHA INHIBITORS Expired - Lifetime DE60102137T2 (en)

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Application Number Priority Date Filing Date Title
US19018300P 2000-03-17 2000-03-17
US23546700P 2000-09-26 2000-09-26
US25206200P 2000-11-20 2000-11-20
PCT/US2001/008336 WO2001070734A2 (en) 2000-03-17 2001-03-15 Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha

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DE60102137D1 DE60102137D1 (en) 2004-04-01
DE60102137T2 true DE60102137T2 (en) 2004-10-21

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Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040122011A1 (en) * 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
US6455734B1 (en) 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
PE20030320A1 (en) 2001-07-17 2003-04-03 Gruenenthal Chemie SUBSTITUTE DERIVATIVES OF 4-AMINOCICLOHEXANOL
DE10162701A1 (en) * 2001-12-19 2003-07-03 Merck Patent Gmbh pyrrole
DE60331367D1 (en) 2002-12-30 2010-04-01 Angiotech Int Ag ACTIVE COMPOSITION OF FAST GELING POLYMERIC COMPOSITION
US8088737B2 (en) 2003-04-04 2012-01-03 Incyte Corporation Compositions, methods and kits relating to Her-2 cleavage
US7842835B2 (en) 2003-07-07 2010-11-30 Georgetown University Histone deacetylase inhibitors and methods of use thereof
WO2005012221A1 (en) * 2003-08-04 2005-02-10 Ono Pharmaceutical Co., Ltd. Diphenyl ether compound, process for producing the same, and use
NZ542711A (en) 2003-08-20 2008-03-28 Pharmacyclics Inc Acetylene derivatives as inhibitors of histone deacetylase
WO2005035471A1 (en) 2003-10-14 2005-04-21 Ajinomoto Co., Inc. Ether derivative
EP1711495A2 (en) 2004-01-23 2006-10-18 Amgen Inc. Quinoline, quinazoline, pyridine and pyrimidine counds and their use in the treatment of inflammation, angiogenesis and cancer
BRPI0507373A (en) 2004-01-23 2007-07-10 Amgen Inc compounds and method of use
SE0400850D0 (en) * 2004-03-30 2004-03-31 Astrazeneca Ab Novel Compounds
US7638513B2 (en) * 2004-06-02 2009-12-29 Schering Corporation Compounds for the treatment of inflammatory disorders
PE20060426A1 (en) * 2004-06-02 2006-06-28 Schering Corp TARTARIC ACID DERIVATIVES AS INHIBITORS OF MMPs, ADAMs, TACE AND TNF-alpha
EP1778676B1 (en) 2004-07-16 2010-08-25 Schering Corporation Hydantoin derivatives for the treatment of inflammatory disorders
US7488745B2 (en) * 2004-07-16 2009-02-10 Schering Corporation Compounds for the treatment of inflammatory disorders
US7504424B2 (en) * 2004-07-16 2009-03-17 Schering Corporation Compounds for the treatment of inflammatory disorders
TW200626532A (en) * 2004-09-21 2006-08-01 Syngenta Participations Ag Novel insecticides
CA2587642C (en) 2004-11-30 2013-04-09 Amgen Inc. Substituted heterocycles and methods of use
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Substituted Amid derivatives & methods of use
JP2008542355A (en) 2005-05-31 2008-11-27 ファイザー株式会社 Substituted aryloxy-N-bicyclomethylacetamide compounds as VR1 antagonists
PE20071241A1 (en) * 2006-01-17 2008-01-14 Schering Corp HYDANTOIN-DERIVED COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
JP5205971B2 (en) * 2006-01-27 2013-06-05 宇部興産株式会社 Method for producing tetrahydropyran compound
KR20080108129A (en) * 2006-03-17 2008-12-11 라퀄리아 파마 인코포레이티드 Chromane derivatives
WO2007118130A2 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Antibacterial agents
DK2041181T3 (en) * 2006-06-08 2011-08-29 Helmholtz Zentrum Muenchen Specific protease inhibitors and their use in cancer therapy
WO2008019284A1 (en) * 2006-08-04 2008-02-14 Decode Genetics Ehf Phenoxymethylalkyne inhibitors of lta4h for treating inflammation
WO2008109991A1 (en) * 2007-03-09 2008-09-18 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
JP5361857B2 (en) 2007-03-23 2013-12-04 ファイザー・リミテッド Ion channel inhibitors
JP5539864B2 (en) * 2007-06-12 2014-07-02 アカオゲン，インコーポレーテッド Antibacterial agent
CA2694724C (en) * 2007-08-01 2017-09-12 University Health Network Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
EP2020413A1 (en) 2007-08-02 2009-02-04 Bayer CropScience AG Oxaspirocyclical spiro-substituted tetram and tetron acid derivatives
US8859529B2 (en) 2008-09-24 2014-10-14 Merck Sharp & Dohme Corp. Compounds for the treatment of inflammatory disorders
EP2346857B1 (en) 2008-09-24 2019-11-27 Merck Sharp & Dohme Corp. Compounds for the treatment of inflammatory disorders
WO2010054279A1 (en) 2008-11-10 2010-05-14 Schering Corporation Compounds for the treatment of inflammatory disorders
WO2010054278A2 (en) 2008-11-10 2010-05-14 Schering Corporation Compounds for the treatment of inflammatory disorders
UY32582A (en) 2009-04-28 2010-11-30 Amgen Inc 3 KINASE PHOSPHINOSITI INHIBITORS AND / OR MAMMAL OBJECTIVE
FR2950057B1 (en) 2009-09-17 2011-08-26 Galderma Res & Dev NOVEL BENZENE CARBOXYLAMIDE COMPOUNDS, PROCESS FOR THEIR SYNTHESIS AND THEIR USE IN MEDICINE AND COSMETICS
FR2950056B1 (en) 2009-09-17 2011-08-26 Galderma Res & Dev NOVEL BENZENE CARBOXYLAMIDE COMPOUNDS, PROCESS FOR THEIR SYNTHESIS AND THEIR USE IN MEDICINE AND COSMETICS
IN2012DN02763A (en) 2009-09-29 2015-09-18 Glaxo Group Ltd
PL2611776T3 (en) * 2010-09-03 2017-06-30 Lg Life Sciences Ltd Production method of intermediate compound for synthesizing medicament
SG2014011555A (en) 2011-08-15 2014-08-28 Intermune Inc Lysophosphatidic acid receptor antagonists
CN102936216B (en) * 2012-12-05 2015-03-04 南京药石药物研发有限公司 Preparation method of 7,9-dioxo-2,6-aza-spiro[3.5]nona-2-tert-butyl formate and intermediate thereof
WO2014139080A1 (en) * 2013-03-12 2014-09-18 Boehringer Ingelheim International Trading (Shanghai) Co., Ltd. Novel process for the manufacture of 3-oxo-tetrahydrofuran
AU2014334551B2 (en) 2013-10-14 2018-05-10 Eisai R&D Management Co., Ltd. Selectively substituted quinoline compounds
WO2015057659A1 (en) 2013-10-14 2015-04-23 Eisai R&D Management Co., Ltd. Selectively substituted quinoline compounds
CN103965097A (en) * 2014-05-22 2014-08-06 南开大学 Preparation method of 2-piperidone
CN104311473B (en) * 2014-05-27 2016-09-28 斯芬克司药物研发（天津）股份有限公司 A kind of piperidines and preparation method thereof
WO2016105448A1 (en) * 2014-12-22 2016-06-30 Darryl Rideout Imidazoline receptor type 1 ligands for use as therapeutics
ES2695533T3 (en) * 2016-02-01 2019-01-08 Galderma Res & Dev Benzenesulfonamide compounds, method for their synthesis and use in medicine and cosmetics
CN113194954A (en) 2018-10-04 2021-07-30 国家医疗保健研究所 EGFR inhibitors for the treatment of keratoderma
CN110498750B (en) * 2019-09-02 2021-10-15 南通大学 Synthesis method of (R) -4-hydroxy-1-methoxybutyl-2-ylcarbamate
WO2023191425A1 (en) * 2022-03-28 2023-10-05 주식회사 비엔에이치리서치 Electrophysiological screening method for drugs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02256667A (en) * 1988-12-27 1990-10-17 Masatoshi Yamato Condensed quinoline-based compound and production thereof
US5212182A (en) * 1990-10-03 1993-05-18 American Home Products Corpooration Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics
ES2233275T3 (en) * 1995-12-08 2005-06-16 Agouron Pharmaceuticals, Inc. INTERMEDIARIES THAT SERVE FOR THE PREPARATION OF METALOPROTEINASE INHIBITORS.
DE69624081T2 (en) 1995-12-20 2003-06-12 Hoffmann La Roche Matrix metalloprotease inhibitors
EP0818442A3 (en) * 1996-07-12 1998-12-30 Pfizer Inc. Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
AUPP982399A0 (en) 1999-04-19 1999-05-13 Fujisawa Pharmaceutical Co., Ltd. Mmp inhibitor

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