DE60030696D1 - SPECIFIC ANTIBODIES FOR CYP1B1 - Google Patents

SPECIFIC ANTIBODIES FOR CYP1B1

Info

Publication number
DE60030696D1
DE60030696D1 DE60030696T DE60030696T DE60030696D1 DE 60030696 D1 DE60030696 D1 DE 60030696D1 DE 60030696 T DE60030696 T DE 60030696T DE 60030696 T DE60030696 T DE 60030696T DE 60030696 D1 DE60030696 D1 DE 60030696D1
Authority
DE
Germany
Prior art keywords
cyp1b1
cancer
antibodies
specific antibodies
bind
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60030696T
Other languages
German (de)
Other versions
DE60030696T2 (en
Inventor
William Melvin
Ian Murray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Aberdeen
Original Assignee
University of Aberdeen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Aberdeen filed Critical University of Aberdeen
Application granted granted Critical
Publication of DE60030696D1 publication Critical patent/DE60030696D1/en
Publication of DE60030696T2 publication Critical patent/DE60030696T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PExFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used in the diagnosis or treatment of cancers linked to enhanced CYP1B1 expression, including breast cancer, prostate cancer, colorectal cancer, liver cancer and ovarian cancer.
DE60030696T 1999-03-19 2000-03-20 SPECIFIC ANTIBODIES FOR CYP1B1 Expired - Lifetime DE60030696T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9906380 1999-03-19
GBGB9906380.2A GB9906380D0 (en) 1999-03-19 1999-03-19 Monoclonal antibodies specific for cypibi
PCT/GB2000/001030 WO2000056773A1 (en) 1999-03-19 2000-03-20 Antibodies specific for cyp1b1

Publications (2)

Publication Number Publication Date
DE60030696D1 true DE60030696D1 (en) 2006-10-26
DE60030696T2 DE60030696T2 (en) 2007-10-04

Family

ID=10849980

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60030696T Expired - Lifetime DE60030696T2 (en) 1999-03-19 2000-03-20 SPECIFIC ANTIBODIES FOR CYP1B1

Country Status (10)

Country Link
US (2) US7419794B1 (en)
EP (1) EP1163272B1 (en)
JP (2) JP2002543765A (en)
AT (1) ATE339453T1 (en)
AU (1) AU768885B2 (en)
CA (1) CA2365121A1 (en)
DE (1) DE60030696T2 (en)
ES (1) ES2272261T3 (en)
GB (1) GB9906380D0 (en)
WO (1) WO2000056773A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1241945A4 (en) * 1999-11-15 2005-08-17 Dana Farber Cancer Inst Inc Cancer immunotherapy and diagnosis using cytochrome p450 1b1
GB0002835D0 (en) * 2000-02-09 2000-03-29 Melvin William T Drug resistance in cancer
EP1404841B1 (en) 2000-10-31 2011-08-17 Eisai Inc. Cyp1b1 nucleic acids and methods of use
US7385023B1 (en) 2000-11-15 2008-06-10 Trustees Of Boston University Cancer immunotherapy and diagnosis using cytochrome P450 1B1
GB0803071D0 (en) 2008-02-20 2008-03-26 Care Technologies Inc Cancer detection methods and techniques
WO2012075136A2 (en) * 2010-11-30 2012-06-07 Fox Chase Cancer Center Targeting of cyp1b1 in the treatment of head and neck cancer and lung cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4938948A (en) * 1985-10-07 1990-07-03 Cetus Corporation Method for imaging breast tumors using labeled monoclonal anti-human breast cancer antibodies
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5688773A (en) * 1994-08-17 1997-11-18 The General Hospital Corporation Method of selectively destroying neoplastic cells
GB9519490D0 (en) 1995-09-25 1995-11-29 Melvin William T Use of a cytochrome P450 enzyme in tumour cells as a marker and target
US6824780B1 (en) * 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use

Also Published As

Publication number Publication date
CA2365121A1 (en) 2000-09-28
GB9906380D0 (en) 1999-05-12
WO2000056773A1 (en) 2000-09-28
JP2002543765A (en) 2002-12-24
AU3308100A (en) 2000-10-09
JP2011157363A (en) 2011-08-18
DE60030696T2 (en) 2007-10-04
US7419794B1 (en) 2008-09-02
EP1163272A1 (en) 2001-12-19
US20090023160A1 (en) 2009-01-22
ATE339453T1 (en) 2006-10-15
ES2272261T3 (en) 2007-05-01
EP1163272B1 (en) 2006-09-13
AU768885B2 (en) 2004-01-08

Similar Documents

Publication Publication Date Title
ATE516047T1 (en) OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE
NO20026245L (en) Enhancement of antibody cytokine infusion protein mediated immune responses by combination therapy with immunocytokine uptake enhancers
WO2004058171A3 (en) Antibodies against gpr64 and uses thereof
MXPA05008794A (en) Glycorpotein antigen sima135 expressed in metastatic human tumor cells.
DE69942742D1 (en) IMMUNOTHERAPEIC COMPOSITION AND METHOD FOR THE TREATMENT OF PROSTATE CANCER
ATE476992T1 (en) NEUTRALIZABLE EPITOPE OF HGF AND NEUTRALIZING ANTIBODIES BINDING TO IT
SG170080A1 (en) Human monoclonal antibodies to o8e
WO2005046573A3 (en) Pro104 antibody compositions and methods of use
PL367831A1 (en) Recombinant tumor specific antibody and use thereof
TR200103756T2 (en) Treatment with humanized anti-ErbB2 antibodies and anti-ErbB2 antibodies.
DK1893196T3 (en) DIARYLHYDANTOIN CONNECTION
WO2005080431A3 (en) Monoclonal antibodies that specifically bind to folate receptor alpha
ATE478952T1 (en) 36P6D5: SECRETED TUMOR PROTEIN
WO2010060186A8 (en) Antibodies that specifically block the biological activity of a tumor antigen
HK1074670A1 (en) Sets of digital antibodies directed against short epitopes, and methods using same
DK1572087T3 (en) Antibodies with cancer antigen TMEFF2 and applications thereof
EP2504363A4 (en) Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume
DE69939819D1 (en) METHOD FOR CANCER DIAGNOSIS BY MEANS OF A CHIMERIC TOXIN
DE60030696D1 (en) SPECIFIC ANTIBODIES FOR CYP1B1
ATE425460T1 (en) ANTIBODIES, IMMUNOASSAY AND METHOD FOR DETECTING PROSTATE CANCER
WO2007076465A3 (en) Cln248 antibody compositions and methods of use
DE69829001D1 (en) HUMANIZED MONOCLONAL ANTIBODIES WITH HIGH AFFINITY AGAINST DAY-72
DE60231971D1 (en) NDET, AND ITS USE FOR THE TREATMENT OF CANCER
MX2021008453A (en) Formulations of antibodies that bind human cd137 and uses thereof.
WO2004104173A3 (en) Ovr115 ANTIBODY COMPOSITION AND METHODS OF USE

Legal Events

Date Code Title Description
8364 No opposition during term of opposition