DE60028730D1 - MULTIPARTICULAR BISOPROLOL FORMULATION - Google Patents

MULTIPARTICULAR BISOPROLOL FORMULATION

Info

Publication number
DE60028730D1
DE60028730D1 DE60028730T DE60028730T DE60028730D1 DE 60028730 D1 DE60028730 D1 DE 60028730D1 DE 60028730 T DE60028730 T DE 60028730T DE 60028730 T DE60028730 T DE 60028730T DE 60028730 D1 DE60028730 D1 DE 60028730D1
Authority
DE
Germany
Prior art keywords
bisoprolol
formulation
polymeric coating
multiparticular
bisoprolol formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60028730T
Other languages
German (de)
Other versions
DE60028730T2 (en
Inventor
Niall Fanning
Mary Kelly
Paul Stark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Circ Pharma Research and Development Ltd
Original Assignee
Athpharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IE990048A external-priority patent/IE990048A1/en
Application filed by Athpharma Ltd filed Critical Athpharma Ltd
Application granted granted Critical
Publication of DE60028730D1 publication Critical patent/DE60028730D1/en
Publication of DE60028730T2 publication Critical patent/DE60028730T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A multiparticulate bisoprolol formulation for once-daily oral administration, each particle of which comprises a core of bisoprolol or a pharmaceutically acceptable salt thereof surrounded by a polymeric coating, the polymeric coating being effective to achieve an initial lag of bisoprolol release in vivo of at least 4-6 hours following administration and thereafter maintaining therapeutic concentrations of bisoprolol for the remainder of the twenty-four hour period. The formulation can be used for night-time dosing so as to minimise the likelihood of acute cardiovascular occurrences in the well-documented high risk period in the morning.
DE60028730T 1999-01-21 2000-01-17 MULTIPARTICULAR BISOPROLOL FORMULATION Expired - Lifetime DE60028730T2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11681999P 1999-01-21 1999-01-21
IE990048 1999-01-21
US116819P 1999-01-21
IE990048A IE990048A1 (en) 1999-01-21 1999-01-21 Multiparticulate bisoprolol formulation
PCT/IE2000/000005 WO2000042998A1 (en) 1999-01-21 2000-01-17 Multiparticulate bisoprolol formulation

Publications (2)

Publication Number Publication Date
DE60028730D1 true DE60028730D1 (en) 2006-07-27
DE60028730T2 DE60028730T2 (en) 2006-12-28

Family

ID=26320236

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60028730T Expired - Lifetime DE60028730T2 (en) 1999-01-21 2000-01-17 MULTIPARTICULAR BISOPROLOL FORMULATION

Country Status (8)

Country Link
EP (1) EP1143963B1 (en)
JP (1) JP2002535271A (en)
AT (1) ATE329589T1 (en)
AU (1) AU3071300A (en)
CA (1) CA2359709A1 (en)
DE (1) DE60028730T2 (en)
ES (1) ES2267491T3 (en)
WO (1) WO2000042998A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
JP4592041B2 (en) * 2000-11-24 2010-12-01 株式会社Ｎｒｌファーマ New food production methods and applications that improve quality of life
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US6663888B2 (en) 2001-12-14 2003-12-16 Eurand Pharmaceuticals Ltd. Pulsatile release histamine H2 antagonist dosage form
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ589750A (en) 2004-10-21 2012-07-27 Aptalis Pharmatech Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
IES20070122A2 (en) * 2006-12-05 2008-05-28 Michael Hilary Burke A process for the preparation of an orally administered unit dose tablet
TWI471146B (en) 2009-12-02 2015-02-01 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2558396B2 (en) * 1990-06-28 1996-11-27 田辺製薬株式会社 Controlled release formulation
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same

Also Published As

Publication number Publication date
WO2000042998A9 (en) 2001-05-25
JP2002535271A (en) 2002-10-22
ES2267491T3 (en) 2007-03-16
ATE329589T1 (en) 2006-07-15
CA2359709A1 (en) 2000-07-27
EP1143963B1 (en) 2006-06-14
EP1143963A1 (en) 2001-10-17
AU3071300A (en) 2000-08-07
DE60028730T2 (en) 2006-12-28
WO2000042998A1 (en) 2000-07-27

Similar Documents

Publication Publication Date Title
DE60028730D1 (en) MULTIPARTICULAR BISOPROLOL FORMULATION
NZ509028A (en) Stable extended release oral dosage composition comprising a pseudoephedrine-containing core, the core being uniformly covered with a desloratadine-containing film
FR2811571B1 (en) ORAL PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE AND SUSTAINED ABSORPTION OF AN ACTIVE INGREDIENT
WO2002028376A3 (en) Chrono delivery formulations and method of use thereof
PL356962A1 (en) Multi-particulate form of medicament, comprising at least two differently coated forms of pellet
NZ514574A (en) Novel method of treatment
DK1117383T3 (en) Dosage forms comprising therapeutic formulation
ES2180683T3 (en) PREPARATION OF NIFEDIPINE FOR RELEASE WITH LONG-TERM DURATION.
MY126555A (en) Oral pharmaceutical extended release dosage form
WO2001076575A3 (en) The treatment of respiratory diseases
HK1031197A1 (en) Osmotic dosage form comprising first and second coats
HUP0201711A2 (en) Indanyl-substituted benzole carbonamide, method for the production of the same, use thereof as a medicament and pharmaceutical preparations containing the same
NO20013757L (en) Core tablet for controlled release of glicazide after oral administration
ATE286387T1 (en) EXTENDED RELEASE PREPARATION CONTAINING CLARITHROMYCIN
RS54050B1 (en) Formulations and methods for treating amyloidosis
GR1003658B (en) Matrix tablet enabling the prolonged release of trimetazidine after administration by the oral route
CA2256751A1 (en) Coated trimebutine maleate tablet
YU36401A (en) Pharmaceutical composition for modified insulin sensitiser
WO2000008007A3 (en) Cyclopentabenzofuran derivatives and their use
NO20031410L (en) Use of distamycin derivatives for the manufacture of drugs
MXPA05008843A (en) Therapeutic system comprising amoxicillin and clavulanic acid.
NO975680D0 (en) Oral pharmaceutical preparation of piperidinoalkanol compounds in solution form
WO2003105811A3 (en) Controlled release compositions and methods for using same
GB9420748D0 (en) 1,5 benzodiazepine derivatives
ITFI910154A1 (en) MICROCRYSTALLINE FORM OF MECLOPHENAMIC ACID, METHOD AND PHARMACEUTICAL FORMULATIONS

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: CIRC PHARMA RESEARCH AND DEVELOPMENT LTD., DUB, IE

8364 No opposition during term of opposition