DE60027168D1 - ADRENOMEDULLIN FOR THE TREATMENT OF DISORDERS OF THE HARNLASS - Google Patents
ADRENOMEDULLIN FOR THE TREATMENT OF DISORDERS OF THE HARNLASSInfo
- Publication number
- DE60027168D1 DE60027168D1 DE60027168T DE60027168T DE60027168D1 DE 60027168 D1 DE60027168 D1 DE 60027168D1 DE 60027168 T DE60027168 T DE 60027168T DE 60027168 T DE60027168 T DE 60027168T DE 60027168 D1 DE60027168 D1 DE 60027168D1
- Authority
- DE
- Germany
- Prior art keywords
- adrenomedullin
- incontinence
- urination disorder
- composition
- harnlass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004379 Adrenomedullin Human genes 0.000 title abstract 4
- 101800004616 Adrenomedullin Proteins 0.000 title abstract 4
- ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 title abstract 4
- 208000028938 Urination disease Diseases 0.000 abstract 4
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 208000000921 Urge Urinary Incontinence Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000024449 overflow incontinence Diseases 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000011514 reflex Effects 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 206010046494 urge incontinence Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A composition for promoting extension of bladder smooth muscle, comprising adrenomedullin. The composition of the present invention may be used to ameliorate a urination disorder. The urination disorder may be a urinary incontinence selected from the group consisting of urge incontinence, reflex incontinence, and overflow incontinence. According to the present invention, a method is provided for ameliorating a urination disorder using a composition comprising adrenomedullin. Further, use of adrenomedullin in production of a drug for ameliorating a urination disorder is provided.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17754999 | 1999-06-23 | ||
| JP17754999 | 1999-06-23 | ||
| PCT/JP2000/004166 WO2000078338A1 (en) | 1999-06-23 | 2000-06-23 | Compositions for promoting passive elongation of vesical smooth muscle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60027168D1 true DE60027168D1 (en) | 2006-05-18 |
| DE60027168T2 DE60027168T2 (en) | 2007-01-11 |
Family
ID=16032903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60027168T Expired - Fee Related DE60027168T2 (en) | 1999-06-23 | 2000-06-23 | ADRENOMEDULLIN FOR THE TREATMENT OF DISORDERS OF THE HARNLASS |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6852692B1 (en) |
| EP (1) | EP1205186B1 (en) |
| JP (1) | JP4610142B2 (en) |
| AT (1) | ATE322284T1 (en) |
| DE (1) | DE60027168T2 (en) |
| WO (1) | WO2000078338A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004089987A1 (en) * | 2003-04-08 | 2004-10-21 | Genova Ltd. | Secreted polypeptide species associated with cardiovascular disorders |
| US20070082363A1 (en) * | 2003-04-25 | 2007-04-12 | Lydie Bougueleret | Secreted polypeptide species reduced cardiovascular disorders |
| CA2715771C (en) | 2008-02-19 | 2014-10-28 | National University Corporation Asahikawa Medical College | Adrenomedullin production enhancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2774769B2 (en) * | 1993-04-26 | 1998-07-09 | 賢治 寒川 | Adrenomedullin |
| WO1996005221A1 (en) * | 1994-08-16 | 1996-02-22 | Human Genome Sciences, Inc. | Calcitonin receptor |
| US5888963A (en) * | 1996-04-18 | 1999-03-30 | Auckland Uniservices Limited | Treatment of bone disorders with adrenomedullin |
| US20010041355A1 (en) * | 2000-03-24 | 2001-11-15 | Shyam Ramakrishnan | Regulation of human nerve growth factor-related G protein-coupled receptor |
-
2000
- 2000-06-23 EP EP00940830A patent/EP1205186B1/en not_active Expired - Lifetime
- 2000-06-23 AT AT00940830T patent/ATE322284T1/en not_active IP Right Cessation
- 2000-06-23 JP JP2001504401A patent/JP4610142B2/en not_active Expired - Fee Related
- 2000-06-23 WO PCT/JP2000/004166 patent/WO2000078338A1/en active IP Right Grant
- 2000-06-23 DE DE60027168T patent/DE60027168T2/en not_active Expired - Fee Related
- 2000-06-23 US US10/018,924 patent/US6852692B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1205186A1 (en) | 2002-05-15 |
| EP1205186A4 (en) | 2003-06-25 |
| WO2000078338A1 (en) | 2000-12-28 |
| EP1205186B1 (en) | 2006-04-05 |
| US6852692B1 (en) | 2005-02-08 |
| JP4610142B2 (en) | 2011-01-12 |
| ATE322284T1 (en) | 2006-04-15 |
| DE60027168T2 (en) | 2007-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: KANGAWA, KENJI, MINO-SHI, OSAKA, JP |
|
| 8339 | Ceased/non-payment of the annual fee |