DE60008377D1 - BISPIDINE DERIVATIVES FOR THE TREATMENT OF HEART ARRHYTHMIA - Google Patents

BISPIDINE DERIVATIVES FOR THE TREATMENT OF HEART ARRHYTHMIA

Info

Publication number
DE60008377D1
DE60008377D1 DE60008377T DE60008377T DE60008377D1 DE 60008377 D1 DE60008377 D1 DE 60008377D1 DE 60008377 T DE60008377 T DE 60008377T DE 60008377 T DE60008377 T DE 60008377T DE 60008377 D1 DE60008377 D1 DE 60008377D1
Authority
DE
Germany
Prior art keywords
treatment
heart arrhythmia
bispidine derivatives
bispidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60008377T
Other languages
German (de)
Other versions
DE60008377T2 (en
Inventor
Magnus Bjoersne
Marianne Frantsi
Kurt-Juergen Hoffmann
Bengt Ohlsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60008377D1 publication Critical patent/DE60008377D1/en
Publication of DE60008377T2 publication Critical patent/DE60008377T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60008377T 1999-06-16 2000-06-15 BISPIDINE DERIVATIVES FOR THE TREATMENT OF HEART ARRHYTHMIA Expired - Fee Related DE60008377T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9902269A SE9902269D0 (en) 1999-06-16 1999-06-16 Pharmaceutically active compounds
SE9902269 1999-06-16
PCT/SE2000/001252 WO2000076998A1 (en) 1999-06-16 2000-06-15 New bispidine compounds useful in the treatment of cardiac arrhythmias

Publications (2)

Publication Number Publication Date
DE60008377D1 true DE60008377D1 (en) 2004-03-25
DE60008377T2 DE60008377T2 (en) 2004-12-09

Family

ID=20416101

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60008377T Expired - Fee Related DE60008377T2 (en) 1999-06-16 2000-06-15 BISPIDINE DERIVATIVES FOR THE TREATMENT OF HEART ARRHYTHMIA

Country Status (28)

Country Link
EP (1) EP1192156B1 (en)
JP (1) JP2003502327A (en)
KR (1) KR20020042534A (en)
CN (1) CN1187351C (en)
AR (1) AR024392A1 (en)
AT (1) ATE259809T1 (en)
AU (1) AU762040B2 (en)
BR (1) BR0011667A (en)
CA (1) CA2377395A1 (en)
CZ (1) CZ20014493A3 (en)
DE (1) DE60008377T2 (en)
DK (1) DK1192156T3 (en)
EE (1) EE200100679A (en)
ES (1) ES2214291T3 (en)
HK (1) HK1045689A1 (en)
HU (1) HUP0300244A3 (en)
IL (1) IL146751A0 (en)
IS (1) IS6200A (en)
MX (1) MXPA01012926A (en)
NO (1) NO20016120L (en)
NZ (1) NZ516014A (en)
PL (1) PL353155A1 (en)
PT (1) PT1192156E (en)
SE (1) SE9902269D0 (en)
SK (1) SK18292001A3 (en)
TR (1) TR200103635T2 (en)
WO (1) WO2000076998A1 (en)
ZA (1) ZA200109798B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030302A1 (en) * 2000-07-07 2003-08-20 Astrazeneca Ab BISPIDINE COMPOUNDS, PHARMACEUTICAL FORMULATION, USE FOR THE MANUFACTURE OF MEDICINES, PROCESS FOR THE PREPARATION OF THESE INTERMEDIATE COMPOUNDS AND COMPOUNDS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT88381B (en) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh PROCESS FOR THE PREPARATION OF NEW COMPOUNDS 3,7-DIAZABICYCLO (3,3,1) NONANO, AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
DE3732094A1 (en) * 1987-09-24 1989-04-06 Basf Ag BISPID DERIVATIVES AS CLASS III ANTIARRHYTHMICS
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
SE9704709D0 (en) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
SK18292001A3 (en) 2002-12-03
MXPA01012926A (en) 2002-07-30
AU6032300A (en) 2001-01-02
NZ516014A (en) 2003-06-30
PT1192156E (en) 2004-06-30
SE9902269D0 (en) 1999-06-16
IS6200A (en) 2001-12-14
DK1192156T3 (en) 2004-05-17
EP1192156A1 (en) 2002-04-03
BR0011667A (en) 2002-04-02
KR20020042534A (en) 2002-06-05
CZ20014493A3 (en) 2002-05-15
EE200100679A (en) 2003-02-17
JP2003502327A (en) 2003-01-21
ES2214291T3 (en) 2004-09-16
CN1187351C (en) 2005-02-02
DE60008377T2 (en) 2004-12-09
NO20016120D0 (en) 2001-12-14
CN1370165A (en) 2002-09-18
EP1192156B1 (en) 2004-02-18
IL146751A0 (en) 2002-07-25
HUP0300244A3 (en) 2003-12-29
TR200103635T2 (en) 2002-04-22
CA2377395A1 (en) 2000-12-21
AU762040B2 (en) 2003-06-19
NO20016120L (en) 2002-02-18
HK1045689A1 (en) 2002-12-06
ATE259809T1 (en) 2004-03-15
AR024392A1 (en) 2002-10-02
WO2000076998A1 (en) 2000-12-21
ZA200109798B (en) 2003-02-28
WO2000076998B1 (en) 2001-03-08
HUP0300244A2 (en) 2003-06-28
PL353155A1 (en) 2003-10-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee