DE59903993D1 - METHOD FOR PRODUCING EPOTHILON B AND DERIVATIVES THEREOF - Google Patents
METHOD FOR PRODUCING EPOTHILON B AND DERIVATIVES THEREOFInfo
- Publication number
- DE59903993D1 DE59903993D1 DE59903993T DE59903993T DE59903993D1 DE 59903993 D1 DE59903993 D1 DE 59903993D1 DE 59903993 T DE59903993 T DE 59903993T DE 59903993 T DE59903993 T DE 59903993T DE 59903993 D1 DE59903993 D1 DE 59903993D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- epothilon
- producing
- epothilone
- diastereomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Silicon Polymers (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
This invention relates to a process for the production of epothilone B and derivatives as well as intermediate products for this process. In the new process, epothilone B or the derivatives are built up in high yields from the C1-C6, C7-C10 and C11-C20 fragments (2, 3 and 4) that can be obtained at a reasonable price and free of diastereomers (the variable radicals have the meanings that are indicated in the description).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19848306A DE19848306A1 (en) | 1998-10-14 | 1998-10-14 | High yield preparation of cytotoxic or fungicidal compound epothilon B, from phenylsulfonyl-butanol derivative by multistage process via new thiazole derivative intermediates |
PCT/EP1999/007746 WO2000023452A1 (en) | 1998-10-14 | 1999-10-14 | Method for producing epothilone b and derivatives, and intermediate products for this method |
Publications (1)
Publication Number | Publication Date |
---|---|
DE59903993D1 true DE59903993D1 (en) | 2003-02-13 |
Family
ID=7885043
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19848306A Ceased DE19848306A1 (en) | 1998-10-14 | 1998-10-14 | High yield preparation of cytotoxic or fungicidal compound epothilon B, from phenylsulfonyl-butanol derivative by multistage process via new thiazole derivative intermediates |
DE59903993T Expired - Lifetime DE59903993D1 (en) | 1998-10-14 | 1999-10-14 | METHOD FOR PRODUCING EPOTHILON B AND DERIVATIVES THEREOF |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19848306A Ceased DE19848306A1 (en) | 1998-10-14 | 1998-10-14 | High yield preparation of cytotoxic or fungicidal compound epothilon B, from phenylsulfonyl-butanol derivative by multistage process via new thiazole derivative intermediates |
Country Status (11)
Country | Link |
---|---|
US (2) | US6605726B1 (en) |
EP (1) | EP1121364B1 (en) |
JP (1) | JP2002527521A (en) |
AT (1) | ATE230751T1 (en) |
AU (1) | AU763717B2 (en) |
CA (1) | CA2346493A1 (en) |
DE (2) | DE19848306A1 (en) |
DK (1) | DK1121364T3 (en) |
ES (1) | ES2189508T3 (en) |
PT (1) | PT1121364E (en) |
WO (1) | WO2000023452A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
DE69734362T2 (en) | 1996-12-03 | 2006-07-20 | Sloan-Kettering Institute For Cancer Research | SYNTHESIS OF EPOTHILONES, INTERMEDIATE PRODUCTS, ANALOGUES AND USES THEREOF |
FR2775187B1 (en) * | 1998-02-25 | 2003-02-21 | Novartis Ag | USE OF EPOTHILONE B FOR THE MANUFACTURE OF AN ANTIPROLIFERATIVE PHARMACEUTICAL PREPARATION AND A COMPOSITION COMPRISING EPOTHILONE B AS AN IN VIVO ANTIPROLIFERATIVE AGENT |
WO2002030356A2 (en) * | 2000-10-13 | 2002-04-18 | The University Of Mississipi | Synthesis of epothilones and relates analogs |
DE60229143D1 (en) * | 2001-08-23 | 2008-11-13 | Novartis Ag | Cyclopropyl und cyclobutyl epothilon analoge |
ES2337134T3 (en) | 2002-03-12 | 2010-04-21 | Bristol-Myers Squibb Company | DERIVATIVES OF C3-CIANO-EPOTILONE. |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
SI1767535T1 (en) | 2002-08-23 | 2010-03-31 | Sloan Kettering Inst Cancer | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
EP1856255A4 (en) | 2005-02-11 | 2010-01-27 | Univ Southern California | Method of expressing proteins with disulfide bridges |
WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
EA035193B1 (en) | 2010-05-18 | 2020-05-14 | Серулин Фарма Инк. | Compositions and methods for treatment of autoimmune and other diseases |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4138042C2 (en) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilones, their production processes and agents containing these compounds |
US5745850A (en) * | 1994-10-24 | 1998-04-28 | Lucent Technologies, Inc. | Apparatus and method for mobile (e.g. cellular or wireless) telephone call handover and impersonation |
US5734699A (en) * | 1995-05-04 | 1998-03-31 | Interwave Communications International, Ltd. | Cellular private branch exchanges |
ATE218556T1 (en) * | 1995-11-17 | 2002-06-15 | Biotechnolog Forschung Gmbh | EPOTHILONE DERIVATIVES AND THEIR PRODUCTION |
US5809415A (en) * | 1995-12-11 | 1998-09-15 | Unwired Planet, Inc. | Method and architecture for an interactive two-way data communication network |
US6055427A (en) * | 1996-07-18 | 2000-04-25 | Nokia Telecommunications Oy | Hard handoff and a radio system |
US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US6119006A (en) * | 1997-01-03 | 2000-09-12 | Siemens Information And Communication Systems, Inc. | System and method for calendar-based cellular smart switching |
US6430395B2 (en) * | 2000-04-07 | 2002-08-06 | Commil Ltd. | Wireless private branch exchange (WPBX) and communicating between mobile units and base stations |
-
1998
- 1998-10-14 DE DE19848306A patent/DE19848306A1/en not_active Ceased
-
1999
- 1999-10-14 AU AU64717/99A patent/AU763717B2/en not_active Ceased
- 1999-10-14 JP JP2000577178A patent/JP2002527521A/en active Pending
- 1999-10-14 DE DE59903993T patent/DE59903993D1/en not_active Expired - Lifetime
- 1999-10-14 DK DK99952569T patent/DK1121364T3/en active
- 1999-10-14 EP EP99952569A patent/EP1121364B1/en not_active Expired - Lifetime
- 1999-10-14 ES ES99952569T patent/ES2189508T3/en not_active Expired - Lifetime
- 1999-10-14 PT PT99952569T patent/PT1121364E/en unknown
- 1999-10-14 CA CA002346493A patent/CA2346493A1/en not_active Abandoned
- 1999-10-14 US US09/807,370 patent/US6605726B1/en not_active Expired - Fee Related
- 1999-10-14 WO PCT/EP1999/007746 patent/WO2000023452A1/en active IP Right Grant
- 1999-10-14 AT AT99952569T patent/ATE230751T1/en not_active IP Right Cessation
-
2003
- 2003-04-23 US US10/420,716 patent/US20030220503A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU6471799A (en) | 2000-05-08 |
AU763717B2 (en) | 2003-07-31 |
EP1121364A1 (en) | 2001-08-08 |
WO2000023452A1 (en) | 2000-04-27 |
US6605726B1 (en) | 2003-08-12 |
ATE230751T1 (en) | 2003-01-15 |
DK1121364T3 (en) | 2003-03-17 |
EP1121364B1 (en) | 2003-01-08 |
PT1121364E (en) | 2003-04-30 |
JP2002527521A (en) | 2002-08-27 |
CA2346493A1 (en) | 2000-04-27 |
DE19848306A1 (en) | 2000-04-20 |
ES2189508T3 (en) | 2003-07-01 |
US20030220503A1 (en) | 2003-11-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE242329T1 (en) | COMBINATION OF DNA SEQUENCES THAT ALLOWS THE FORMATION OF MODIFIED STARCH IN PLANT CELLS AND PLANTS, METHOD FOR PRODUCING THESE PLANTS | |
ATE230751T1 (en) | METHOD FOR PRODUCING EPOTHILONE B AND DERIVATIVES THEREOF | |
DE60014150D1 (en) | METHOD FOR PRODUCING BIOPOLYMERS WITH CHANGED PROPERTIES | |
DE60100405D1 (en) | Process for the production of alloy powders | |
ATE340159T1 (en) | METHOD FOR PRODUCING ALFENTANIL, SUFENTANIL AND REMIFENTANIL | |
DE69509432D1 (en) | Process for the production of titanium alloy products | |
DE60027765D1 (en) | METHOD FOR PRODUCING MECHANICAL POWDER | |
ATE394490T1 (en) | MUTANT BACTERIAL STRAINS FROM THE GENUS SPHINGONOMAS THAT ARE DEFECTIVE IN THE PRODUCTION OF POLYHYDROXYBUTYRATES, AND METHOD FOR THE CLARIFICATION OF SPHINGANS | |
DE60327009D1 (en) | Process for the production of metallic and ceramic products | |
ATE238814T1 (en) | DENDRIMERE FULLERENE DERIVATIVES, METHOD OF PRODUCTION AND USE AS NEUROPROTECTIONS | |
HK1070350A1 (en) | Protected 3.5-dihydroxy-2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof | |
ATE201025T1 (en) | METHOD FOR PRODUCING CEPHALOSPORINS AND INTERMEDIATE PRODUCTS IN THIS METHOD | |
HUP0204069A2 (en) | Novel processes for making- and a new crystalline form of- leflunomide and pharmaceutical composition containing it | |
DE69841553D1 (en) | METHOD FOR THE PRODUCTION OF DEHOLED PHOSPHTIDES | |
DE69625151D1 (en) | Process for the continuous production of polyorganosiloxane particles | |
DE69926223D1 (en) | PROCESS FOR PRODUCING INTERMEDIATE PRODUCTS | |
DE59201325D1 (en) | Improved process for the production of polyenes. | |
DE69611253D1 (en) | PROCESS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF 3- (1-PIPERAZINYL) -1,2-BENZISOTHIAZOLES | |
DE59907056D1 (en) | PROCESS FOR THE PRODUCTION OF CYCLES | |
DE69520063D1 (en) | Process for the production of organic pigments | |
ATE96143T1 (en) | PROCESSES FOR PRODUCTION OF PURIFIED, FAT ALKYLDIETHANOLAMIDES, THE PRODUCTS MADE THEREOF AND THEIR USE. | |
DE59708352D1 (en) | Process for the production of printed products and products produced by the process | |
ATA71099A (en) | METHOD FOR PRODUCING APPLICABLE MATERIAL FOR A DIRECT REDUCTION PROCESS | |
DE69906393D1 (en) | METHOD FOR PRODUCING AN ENERGY SOFTENER | |
AU2003288744A1 (en) | Machine and process for shaping, annealing and quenching glass sheets, or similar materials |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8330 | Complete renunciation |