DE571864C - Process for the production of a durable organ extract - Google Patents

Process for the production of a durable organ extract

Info

Publication number
DE571864C
DE571864C DER77627D DER0077627D DE571864C DE 571864 C DE571864 C DE 571864C DE R77627 D DER77627 D DE R77627D DE R0077627 D DER0077627 D DE R0077627D DE 571864 C DE571864 C DE 571864C
Authority
DE
Germany
Prior art keywords
extract
durable
production
organ extract
parathyroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DER77627D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DAVID ROTHSCHILD DR
Original Assignee
DAVID ROTHSCHILD DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DAVID ROTHSCHILD DR filed Critical DAVID ROTHSCHILD DR
Priority to DER77627D priority Critical patent/DE571864C/en
Application granted granted Critical
Publication of DE571864C publication Critical patent/DE571864C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Verfahren zur Herstellung eines haltbaren Organ-Extraktes Vermischt man Nebennieren-Extrakt mit ebenschilddrüsen-Extrakt, so treten nach N N kürzerer oder längerer Zeit Ausflockungen, Verfärbungen und gelartige Zersetzungen ein, die das Präparat praktisch unbrauchbar machen.Process for the production of a durable organ extract If one mixes adrenal gland extract with parathyroid gland extract, flocculation, discoloration and gel-like decomposition occur for a shorter or longer time after N N, which make the preparation practically unusable.

Gemäß vorliegender Erfindung wird ein einheitliches, wertvolles, neues Erzeugnis nach einem bestimmten chemischen Verfahren hergestellt, das unbegrenzt haltbar und deshalb praktisch jederzeit verwendbar bleibt.According to the present invention, there is a uniform, valuable, new Product manufactured by a specific chemical process that is unlimited durable and therefore can be used practically at any time.

In dem durch das vorliegende Verfahren erreichten kolloidchemischen Gleichgewicht von Nebennieren-Extrakt und Nebenschilddrüsen-Extrakt verliert das Nebennieren-Extrakt seine Neigung zu chinbider Abartung, während an dem Nebenschilddrüsen-Extrakt durch das vorliegende Verfahren insofern eine chemische Veränderung nachgewiesen werden kann, als die an dem nichtvorbehandelten Nebenschilddrüsen-Extrakt regelmäßig nachweisbare Millonsche Reaktion durch das vorliegende Verfahren verschwindet. Diese chemischen Veränderungen der Ausgangs-Extrakte werden dadurch herbeigeführt, daß die Extrakte bei einer Temperätur von 35' C auf die für den gedachten Zweck gefundene und bestimmte Wasserstoffionenkonzentration von 3,5 eingestellt werden. Zur Erreichung des (pH) von 3,5 ist ein Zusatz einer etwa roo°1oigen Essigsäure in der Menge von o,oo5 g für je r ccm Extrakt erforderlich; in der Regel ist die WasserstofF-ionenkonzentration von 3,5 das Optimum zur Erreichung der Haltbarkeit. In Ausnahmefällen, besonders bei Verwendung ausländischer Extraktstoffe"kann die für die Haltbarkeit günstigste Wasserstoffionenkonzentration in geringen Grenzen von 3,3 bis 3,7 schwanken, in der Regel liegt sie bei 3,5. Ausführungsbeispiel Zur Herstellung von zo ccm Enderzeugnis werden 5 mg Tebennieren-Extrakt in 5 ccm Lösung mit dem Extrakt aus r g Nebenschilddrüsen-Substanz in 5 ccm Lösung bei 35' C zusammengebracht unter Zusatz von 5 cg einer roo°/oigen Essigsäure. An Stelle der Essigsäure können auch Mineralsäuren, wie Salz-, Schwefel-, Phosphorsäure, auch Milchsäure, diese jedoch nur in ihren Alkalisalzen, in einer auf das PH von 3,5 abgestimmten Menge treten.In the colloid-chemical equilibrium of adrenal gland extract and parathyroid extract achieved by the present process, the adrenal gland extract loses its tendency to become quinoidal, while a chemical change can be detected in the parathyroid gland extract by the present process to the extent that that in the Untreated parathyroid extract regularly detectable Millon's reaction disappears by the present process. These chemical changes in the starting extracts are brought about by adjusting the extracts at a temperature of 35 ° C. to the hydrogen ion concentration of 3.5 found and determined for the intended purpose. In order to achieve the (pH) of 3.5, an addition of about 100% acetic acid in the amount of 0.05 g for each ml of extract is necessary; As a rule, the hydrogen ion concentration of 3.5 is the optimum for achieving the shelf life. In exceptional cases, especially when using foreign extracts, the hydrogen ion concentration which is most favorable for the shelf life can vary within small limits from 3.3 to 3.7, usually around 3.5 -Extract in 5 cc solution with the extract from rg parathyroid substance in 5 cc solution at 35 ° C with the addition of 5 cg of a percent acetic acid. Instead of acetic acid, mineral acids such as hydrochloric, sulfur, Phosphoric acid, also lactic acid, but only in their alkali salts, in an amount adjusted to the PH of 3.5.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines haltbaren Organ-Extraktes, dadurch gekennzeichnet, daß man Nebennieren-Extrakt und @Tebenschilddrüsen-Extrakt bei Temperaturen von etwa 35° C zusammenbringt und auf eine Wasserstaffionenkonzentration von 3,5 einstellt.PATENT CLAIM: Process for the production of a durable organ extract, characterized in that one adrenal gland extract and @ parathyroid gland extract brings together at temperatures of about 35 ° C and to a water staffion concentration of 3.5.
DER77627D 1929-03-23 1929-03-23 Process for the production of a durable organ extract Expired DE571864C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DER77627D DE571864C (en) 1929-03-23 1929-03-23 Process for the production of a durable organ extract

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DER77627D DE571864C (en) 1929-03-23 1929-03-23 Process for the production of a durable organ extract

Publications (1)

Publication Number Publication Date
DE571864C true DE571864C (en) 1933-03-06

Family

ID=7415602

Family Applications (1)

Application Number Title Priority Date Filing Date
DER77627D Expired DE571864C (en) 1929-03-23 1929-03-23 Process for the production of a durable organ extract

Country Status (1)

Country Link
DE (1) DE571864C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE940133C (en) * 1949-10-18 1956-03-08 Heinrich Schmidt Process for obtaining highly effective organ extracts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE940133C (en) * 1949-10-18 1956-03-08 Heinrich Schmidt Process for obtaining highly effective organ extracts

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