DE554158C - Process for the preparation of a compound from diaethylbarbituric acid and 4-dimethylamino-1-phenyl-2,3-dimethyl-5-pyrazolone - Google Patents

Process for the preparation of a compound from diaethylbarbituric acid and 4-dimethylamino-1-phenyl-2,3-dimethyl-5-pyrazolone

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Publication number
DE554158C
DE554158C DEC37592D DEC0037592D DE554158C DE 554158 C DE554158 C DE 554158C DE C37592 D DEC37592 D DE C37592D DE C0037592 D DEC0037592 D DE C0037592D DE 554158 C DE554158 C DE 554158C
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Germany
Prior art keywords
dimethyl
pyrazolone
compound
phenyl
preparation
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Expired
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DEC37592D
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German (de)
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Schering Kahlbaum AG
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Schering Kahlbaum AG
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Publication date
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Publication of DE554158C publication Critical patent/DE554158C/en
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  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Darstellung einer Verbindung aus Diäthylbarbitursäure und 4-Dimethylamino-1-phenyl-2, 3-dimethyl-5-pyrazolon Nach vorliegender Erfindung kann man eine Verbindung aus Diäthylbarbitursäure und 4-Dimethvlamino-i-phenyl-2, 3-dimethyl-5-pyrazolon in der Weise erhalten, daß man die Komponenten im molekularen Verhältnis in organischen Lösungsmitteln bei Temperaturen unter ioo° löst. Man kann das Verfahren auch unter Luftabschluß im Kohlensäurestrom ausführen.Process for the preparation of a compound from diethylbarbituric acid and 4-dimethylamino-1-phenyl-2,3-dimethyl-5-pyrazolone according to the present invention one can use a compound of diethylbarbituric acid and 4-dimethvlamino-i-phenyl-2, 3-dimethyl-5-pyrazolone obtained in such a way that one of the components in the molecular Ratio dissolves in organic solvents at temperatures below 100 °. One can carry out the process in the absence of air in a flow of carbonic acid.

Die erwähnte Verbindung zeichnet sich sowohl durch schmerzlindernde als auch durch schlafmachende Eigenschaften aus.The mentioned compound is characterized by both pain relieving as well as sleep-inducing properties.

Beispiel i 2,3 Teile 4-Dimethylamino-i-phenyl-2, 3-dimethyl-5-pyrazolon werden mit 1,8 Teilen Diäthylbarbitursäure und 2 Teilen Alkohol im Wasserbad allmählich auf 70° und darauf '/2 Stunde auf 7o bis 8o° erwärmt, bis eine klare Flüssigkeit entstanden ist. Nach Verdunsten des Alkohols im Vakuum erhält man die molekulare Verbindung, die bei etwa i 12 bis 1150 schmilzt (ein. kleiner Rest schmilzt zwischen 135 bis i45°) und in Wasser klar löslich ist.Example i 2.3 parts of 4-dimethylamino-i-phenyl-2,3-dimethyl-5-pyrazolone are mixed with 1.8 parts of diethylbarbituric acid and 2 parts of alcohol in a water bath gradually to 70 ° and then 1/2 hour to 7o to 8o ° heated until a clear liquid is formed. After the alcohol has evaporated in vacuo, the molecular compound is obtained, which melts at about 12 to 1150 (a small remainder melts between 135 to 45 °) and is clearly soluble in water.

Beispiel e Man verfährt wie in Beispiel i, ersetzt aber den Alkohol durch 3 bis 4 Teile Aceton und erwärmt 1/y Stunde auf 6o bis 65° Beispiel 3 46,23 Teile 4-Dimethylamino-i-phenyl-2, 3-dimethyl-5-pyrazolon werden mit 36,82 Teilen Diäthylbarbitursäure und 28,5 Teilen Alkohol unter Luftabschluß im Kohlensäurestrom erwärmt, bis eine klare Flüssigkeit entsteht. Man läßt im Kohlensäurestrom erkalten und destilliert den Alkohol im Vakuum ab.Example e Proceed as in example i, but replace the alcohol by 3 to 4 parts of acetone and heated 1 / y hour to 60 to 65 ° Example 3 46.23 Parts of 4-dimethylamino-i-phenyl-2,3-dimethyl-5-pyrazolone are 36.82 parts Diethylbarbituric acid and 28.5 parts of alcohol in the absence of air in a stream of carbonic acid heated until a clear liquid is formed. It is allowed to cool in a stream of carbonic acid and distilled off the alcohol in vacuo.

Claims (2)

PATENTANSPRÜCHE: i. Verfahren zur Darstellung einer Verbindung aus Diätlaylbarbitursät#Y" und 4-Diirnethylamiiio-i-plfenyl-2, 3-dimethyl-5-pyrazolon, dadurch gekennzeichnet, daß man die Komponenten in molekularem Verhältnis in organischen Lösungsmitteln bei Temperaturen unter ioo° löst und das Lösungsmittel entfernt, zweckmäßig durch Abdunsten im Vakuum bei gewöhnlicher Temperatur. PATENT CLAIMS: i. Process for the preparation of a compound of dietary barbiturates # Y "and 4-Diirnethylamiiio-i-plfenyl-2, 3-dimethyl-5-pyrazolone, characterized in that the components are dissolved in a molecular ratio in organic solvents at temperatures below 100 ° and that Solvent removed, expediently by evaporation in vacuo at ordinary temperature. 2. Ausführungsform des Verfahrens nach Anspruch i, dadurch gekennzeichnet, daß man unter Luftabschluß im Kohlensäurestrom arbeitet.2nd embodiment of the method according to claim i, characterized in that with the exclusion of air works in the carbonic acid stream.
DEC37592D 1924-12-24 1925-12-13 Process for the preparation of a compound from diaethylbarbituric acid and 4-dimethylamino-1-phenyl-2,3-dimethyl-5-pyrazolone Expired DE554158C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT554158X 1924-12-24

Publications (1)

Publication Number Publication Date
DE554158C true DE554158C (en) 1932-07-05

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ID=3676502

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Application Number Title Priority Date Filing Date
DEC37592D Expired DE554158C (en) 1924-12-24 1925-12-13 Process for the preparation of a compound from diaethylbarbituric acid and 4-dimethylamino-1-phenyl-2,3-dimethyl-5-pyrazolone

Country Status (1)

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DE (1) DE554158C (en)

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