DE50301244D1 - Pharmaceutical preparations with a combination of in each case at least one representative of the antibiotics and antiphlogistics, processes for their preparation and their use - Google Patents

Pharmaceutical preparations with a combination of in each case at least one representative of the antibiotics and antiphlogistics, processes for their preparation and their use

Info

Publication number
DE50301244D1
DE50301244D1 DE50301244T DE50301244T DE50301244D1 DE 50301244 D1 DE50301244 D1 DE 50301244D1 DE 50301244 T DE50301244 T DE 50301244T DE 50301244 T DE50301244 T DE 50301244T DE 50301244 D1 DE50301244 D1 DE 50301244D1
Authority
DE
Germany
Prior art keywords
water
antiphlogistics
antibiotics
representative
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE50301244T
Other languages
German (de)
Inventor
Dr Vogt
Dr Schnabelrauch
Dr Kuehn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kulzer GmbH
Original Assignee
Heraeus Kulzer GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heraeus Kulzer GmbH filed Critical Heraeus Kulzer GmbH
Priority to DE50301244T priority Critical patent/DE50301244D1/en
Application granted granted Critical
Publication of DE50301244D1 publication Critical patent/DE50301244D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Pharmaceutical composition (C1) comprises a salt of an antibiotic (I), namely gentamicin, clindamycin, neomycin, streptomycin, tetracycline, doxycycline, oxytetracycline or rolitetracycline, with an antiinflammatory agent (II), namely ibuprofen, naproxen, indomethacin, dexamethasone 21-phosphate, dexamethasone 21-sulfate, triamcinolone 21-phosphate or triamcinolone 21-sulfate. Independent claims are also included for: (1) pharmaceutical composition (C2) comprising tablets or pellets formed from a mixture of a water-soluble salt of (I), a water-soluble salt of (II) and an excipient; (2) production of C1 by the action of water or an aqueous medium on C1 to form a sparingly water-soluble antiinflammatory-antibiotic salt in the tablets or pellets.
DE50301244T 2002-06-21 2003-05-28 Pharmaceutical preparations with a combination of in each case at least one representative of the antibiotics and antiphlogistics, processes for their preparation and their use Expired - Lifetime DE50301244D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE50301244T DE50301244D1 (en) 2002-06-21 2003-05-28 Pharmaceutical preparations with a combination of in each case at least one representative of the antibiotics and antiphlogistics, processes for their preparation and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10227938A DE10227938B4 (en) 2002-06-21 2002-06-21 Pharmaceutical preparation, process for its preparation and its use
DE50301244T DE50301244D1 (en) 2002-06-21 2003-05-28 Pharmaceutical preparations with a combination of in each case at least one representative of the antibiotics and antiphlogistics, processes for their preparation and their use

Publications (1)

Publication Number Publication Date
DE50301244D1 true DE50301244D1 (en) 2006-02-09

Family

ID=29716607

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10227938A Expired - Fee Related DE10227938B4 (en) 2002-06-21 2002-06-21 Pharmaceutical preparation, process for its preparation and its use
DE50301244T Expired - Lifetime DE50301244D1 (en) 2002-06-21 2003-05-28 Pharmaceutical preparations with a combination of in each case at least one representative of the antibiotics and antiphlogistics, processes for their preparation and their use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10227938A Expired - Fee Related DE10227938B4 (en) 2002-06-21 2002-06-21 Pharmaceutical preparation, process for its preparation and its use

Country Status (12)

Country Link
US (1) US7345024B2 (en)
EP (1) EP1374872B1 (en)
JP (1) JP4076154B2 (en)
CN (1) CN1228087C (en)
AT (1) ATE305308T1 (en)
AU (1) AU2003204861B2 (en)
BR (1) BR0301707A (en)
CA (1) CA2432009C (en)
DE (2) DE10227938B4 (en)
DK (1) DK1374872T3 (en)
ES (1) ES2250785T3 (en)
ZA (1) ZA200304797B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2542509A1 (en) * 2003-10-29 2005-05-19 Idexx Laboratories, Inc. Salts of pharmacologically active compounds
DE102004060666B3 (en) 2004-12-15 2006-03-30 Heraeus Kulzer Gmbh Antibiotic-containing bone substitute material comprises a compacted mixture of antibiotic-containing mineral granules and a binder
DE102016204899A1 (en) 2016-03-23 2017-09-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Implant body with active substance carrier layer and delivery control layer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3091572A (en) * 1962-07-16 1963-05-28 Schering Corp Gentamycin and method of production
FR6476M (en) 1967-06-06 1968-11-18
FR2272680B1 (en) 1974-05-29 1978-07-21 Hosbon Sa Lab
DE2843963A1 (en) * 1978-10-09 1980-04-24 Merck Patent Gmbh BODY-RESORBABLE SHAPED MATERIAL BASED ON COLLAGEN AND THEIR USE IN MEDICINE
DE3206725A1 (en) * 1981-05-13 1982-12-02 Merck Patent Gmbh, 6100 Darmstadt PERSONALLY SOLUBLE SALTS OF AMINOGLYCOSIDANTIBIOTICS
DE3248328A1 (en) 1982-12-28 1984-06-28 Bayer Ag, 5090 Leverkusen Aminoglycoside salts of low solubility, and formulations containing these with delayed release of active substance
GB2209938B (en) * 1987-09-21 1991-04-10 American Cyanamid Co Neomycin-containing pharmaceutical compositions
CS275231B2 (en) * 1989-09-29 1992-02-19 Ustav Makormolekularni Chemie Medicine bottle
JP3016587B2 (en) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク Combination of non-steroidal anti-inflammatory drug and tetracycline
AU731799B2 (en) * 1997-05-06 2001-04-05 Norbrook Laboratories Limited Improvements in or relating to long-acting antimicrobials

Also Published As

Publication number Publication date
JP4076154B2 (en) 2008-04-16
ES2250785T3 (en) 2006-04-16
DE10227938B4 (en) 2006-07-20
DK1374872T3 (en) 2005-11-14
AU2003204861B2 (en) 2005-08-25
JP2004043464A (en) 2004-02-12
CA2432009C (en) 2010-09-14
DE10227938A1 (en) 2004-01-15
ATE305308T1 (en) 2005-10-15
EP1374872B1 (en) 2005-09-28
EP1374872A1 (en) 2004-01-02
AU2003204861A1 (en) 2004-01-15
CN1480217A (en) 2004-03-10
ZA200304797B (en) 2003-09-18
CN1228087C (en) 2005-11-23
US20040067253A1 (en) 2004-04-08
BR0301707A (en) 2004-08-24
US7345024B2 (en) 2008-03-18
CA2432009A1 (en) 2003-12-21

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