DE50108086D1 - METHOD FOR THE ANALYSIS OF EXOGENEROUS AND ENDOGENOUS CELL ACTIVATION - Google Patents

METHOD FOR THE ANALYSIS OF EXOGENEROUS AND ENDOGENOUS CELL ACTIVATION

Info

Publication number
DE50108086D1
DE50108086D1 DE50108086T DE50108086T DE50108086D1 DE 50108086 D1 DE50108086 D1 DE 50108086D1 DE 50108086 T DE50108086 T DE 50108086T DE 50108086 T DE50108086 T DE 50108086T DE 50108086 D1 DE50108086 D1 DE 50108086D1
Authority
DE
Germany
Prior art keywords
receptors
cell activation
exogenous
endogenous cell
exogenerous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE50108086T
Other languages
German (de)
Inventor
Gerd Schmitz
Alexandra Goetz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KLINIKUM INST fur KLINIS, University of
Original Assignee
KLINIKUM INST fur KLINIS, University of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KLINIKUM INST fur KLINIS, University of filed Critical KLINIKUM INST fur KLINIS, University of
Priority to DE50108086T priority Critical patent/DE50108086D1/en
Priority claimed from PCT/DE2001/000817 external-priority patent/WO2001065257A2/en
Application granted granted Critical
Publication of DE50108086D1 publication Critical patent/DE50108086D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Analyzing exogenous and endogenous cell activation comprises measuring the assembly of receptors into a CD14-containing receptor cluster (RC), is new. Independent claims are also included for the following: (1) diagnosing: (i) systemic inflammation: or (ii) arteriosclerosis or inflammatory disease of coronary/cerebral arteries, or their precursors, by using the new method to determine energy transfer in monocytes; and (2) treatment of the specified conditions with compounds (I) that neutralize exogenous or endogenous proinflammatory molecules, phospholipids, complement-regulating proteins, Fc psi or scavenger receptors, integrin-associated proteins, lipopolysaccharide (LPS)-associated receptors and/or G-protein receptors.
DE50108086T 2000-06-05 2001-03-05 METHOD FOR THE ANALYSIS OF EXOGENEROUS AND ENDOGENOUS CELL ACTIVATION Expired - Fee Related DE50108086D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE50108086T DE50108086D1 (en) 2000-06-05 2001-03-05 METHOD FOR THE ANALYSIS OF EXOGENEROUS AND ENDOGENOUS CELL ACTIVATION

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10027308A DE10027308A1 (en) 2000-06-05 2000-06-05 Analyzing endogenous or exogenous cell activation for the diagnosis of e.g systemic inflammation comprises measuring assembly of CD14-containing receptor cluster
PCT/DE2001/000817 WO2001065257A2 (en) 2000-03-03 2001-03-05 Method for the analysis of exogenic and endogenic cell activation
DE50108086T DE50108086D1 (en) 2000-06-05 2001-03-05 METHOD FOR THE ANALYSIS OF EXOGENEROUS AND ENDOGENOUS CELL ACTIVATION

Publications (1)

Publication Number Publication Date
DE50108086D1 true DE50108086D1 (en) 2005-12-22

Family

ID=7644423

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10027308A Ceased DE10027308A1 (en) 2000-03-03 2000-06-05 Analyzing endogenous or exogenous cell activation for the diagnosis of e.g systemic inflammation comprises measuring assembly of CD14-containing receptor cluster
DE50108086T Expired - Fee Related DE50108086D1 (en) 2000-06-05 2001-03-05 METHOD FOR THE ANALYSIS OF EXOGENEROUS AND ENDOGENOUS CELL ACTIVATION

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10027308A Ceased DE10027308A1 (en) 2000-03-03 2000-06-05 Analyzing endogenous or exogenous cell activation for the diagnosis of e.g systemic inflammation comprises measuring assembly of CD14-containing receptor cluster

Country Status (2)

Country Link
AT (1) ATE310246T1 (en)
DE (2) DE10027308A1 (en)

Also Published As

Publication number Publication date
ATE310246T1 (en) 2005-12-15
DE10027308A1 (en) 2001-12-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee