DE50012777D1 - Process for the production of neuronal cell material - Google Patents

Process for the production of neuronal cell material

Info

Publication number
DE50012777D1
DE50012777D1 DE50012777T DE50012777T DE50012777D1 DE 50012777 D1 DE50012777 D1 DE 50012777D1 DE 50012777 T DE50012777 T DE 50012777T DE 50012777 T DE50012777 T DE 50012777T DE 50012777 D1 DE50012777 D1 DE 50012777D1
Authority
DE
Germany
Prior art keywords
tissue
neuronal
cells
expansion
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE50012777T
Other languages
German (de)
Inventor
Horst Peschel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuroprogen GmbH Leipzig
Original Assignee
Neuroprogen GmbH Leipzig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuroprogen GmbH Leipzig filed Critical Neuroprogen GmbH Leipzig
Priority to DE50012777T priority Critical patent/DE50012777D1/en
Application granted granted Critical
Publication of DE50012777D1 publication Critical patent/DE50012777D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Materials For Medical Uses (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention relates to neuronal tissue which is suitable to restore neuronal deficits following transplantation. To reduce immunological side effects and to increase the microbiological and genetic safety of the tissue we propose tissue that does not contain glial cells and is maintained in vitro for prolonged periods. The method to generate expandable determined neuronal progenitor cell cultures includes the following procedures: dissection of appropriate mammalian brain regions, isolation of progenitor cells, expansion of progenitor cells, selection and expansion of individual cells and priming.
DE50012777T 1999-06-19 2000-06-19 Process for the production of neuronal cell material Expired - Fee Related DE50012777D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE50012777T DE50012777D1 (en) 1999-06-19 2000-06-19 Process for the production of neuronal cell material

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19928210A DE19928210B4 (en) 1999-06-19 1999-06-19 Neuronal cell material and method for its production
PCT/DE2000/001932 WO2000078931A2 (en) 1999-06-19 2000-06-19 Neuronal cell material, use of said material as a transplant and method for producing the same
DE50012777T DE50012777D1 (en) 1999-06-19 2000-06-19 Process for the production of neuronal cell material

Publications (1)

Publication Number Publication Date
DE50012777D1 true DE50012777D1 (en) 2006-06-22

Family

ID=7911909

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19928210A Expired - Fee Related DE19928210B4 (en) 1999-06-19 1999-06-19 Neuronal cell material and method for its production
DE50012777T Expired - Fee Related DE50012777D1 (en) 1999-06-19 2000-06-19 Process for the production of neuronal cell material

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19928210A Expired - Fee Related DE19928210B4 (en) 1999-06-19 1999-06-19 Neuronal cell material and method for its production

Country Status (10)

Country Link
US (1) US20060099192A1 (en)
EP (1) EP1185625B1 (en)
AT (1) ATE326526T1 (en)
AU (1) AU6424900A (en)
CY (1) CY1105067T1 (en)
DE (2) DE19928210B4 (en)
DK (1) DK1185625T3 (en)
ES (1) ES2259608T3 (en)
PT (1) PT1185625E (en)
WO (1) WO2000078931A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10134667A1 (en) * 2001-07-20 2003-02-06 Neuroprogen Gmbh Leipzig Process for the production of isolated cell cultures, culture medium for the cultivation of cell cultures and cell culture
US8785193B2 (en) * 2006-09-14 2014-07-22 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Dissection tool and methods of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082670A (en) * 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5411883A (en) * 1989-12-26 1995-05-02 Somatix Therapy Corporation Proliferated neuron progenitor cell product and process
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5175103A (en) * 1991-10-21 1992-12-29 Trustees Of University Of Pennsylvania Preparation of pure cultures of post-mitotic human neurons
US5753505A (en) * 1995-07-06 1998-05-19 Emory University Neuronal progenitor cells and uses thereof
WO1999001159A1 (en) * 1997-07-04 1999-01-14 University Of Utah Research Foundation Lineage-restricted neuronal precursors
US6165783A (en) * 1997-10-24 2000-12-26 Neuro Spheres Holdings Ltd. Erythropoietin-mediated neurogenesis
US6184035B1 (en) * 1998-11-18 2001-02-06 California Institute Of Technology Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
US6610540B1 (en) * 1998-11-18 2003-08-26 California Institute Of Technology Low oxygen culturing of central nervous system progenitor cells

Also Published As

Publication number Publication date
CY1105067T1 (en) 2010-03-03
ATE326526T1 (en) 2006-06-15
WO2000078931A3 (en) 2001-05-31
PT1185625E (en) 2006-07-31
DE19928210A1 (en) 2000-12-21
WO2000078931A2 (en) 2000-12-28
AU6424900A (en) 2001-01-09
EP1185625A2 (en) 2002-03-13
EP1185625B1 (en) 2006-05-17
DK1185625T3 (en) 2006-08-28
US20060099192A1 (en) 2006-05-11
DE19928210B4 (en) 2005-08-18
ES2259608T3 (en) 2006-10-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee