DE4831T1 - 2,6-Dialkoxybenzamides, intermediates, processes for their preparation, compositions and methods of treatment of psychosis - Google Patents

Claims (12)

000,831 claims 1. Compound of Formula 5 ,1 QR or a pharmaceutically acceptable salt thereof, wherein R is an alkyl group having 1 to 3 carbon atoms 2 and R and R are the same or different and each represent a hydrogen atom, chlorine atom or bromine atom. 2. A compound according to claim 1 of the formula I, wherein R is a Denotes an alkyl group having 1 to 3 carbon atoms and 2 R and R are identical or different and each represent a hydrogen atom, chlorine atom or bromine atom, where 2 R is a chlorine atom or a bromine atom when R is a hydrogen atom. 25th 3. A compound according to claim 1 of the formula I, wherein R is a 2 Is methyl group and R and R are the same or different and each represent a chlorine atom or a bromine atom. 30th 4. A compound according to any one of claims 1 to 3 in the form of a substantially pure stereoisomer. 5. Process for the preparation of a compound of Formula 35 030556/0038 000Λ831 NS 1 2 I.
C. j // CONHCH 2 ^H 5 ν OR R ² ' > - JR ¹ or a pharmaceutically acceptable salt thereof, wherein R is an alkyl group having 1 to 3 carbon atoms 2 3 and R and R are identical or different and each represent a hydrogen atom, chlorine atom or bromine atom, characterized in that a compound of the formula CO-Z OR 12 3 wherein R, R and R have the above meanings and -CO-Z is a reactive group which is capable of with a Amino group to react to form an amide residue with the compound H ₂ N-CH ₂ to form a compound of the formula I and then optionally converting the compound obtained into a pharmaceutically acceptable salt thereof and / or into a substantially pure stereoisomer thereof leads. 6. Compounds useful as intermediates for the preparation of therapeutically valuable 2,6-dialkoxybehzamides, 030556/0038 characterized by the general formula U ^) COOH ^ ¹ OR wherein R is an alkyl group having 1 to 3 carbon atoms means. 7. Pharmaceutical preparation containing as active ingredient a therapeutically effective amount of at least one compound of the formula
15th CONHCH- 2> K CH ₁ or a pharmaceutically acceptable salt "thereof, where R is an alkyl group with 1 to 3 carbon 2 3 atoms and R and R are identical or different and each represent a hydrogen atom, chlorine atom or Bromine atom means in connection with a pharmaceutically acceptable carrier material. 8. A pharmaceutical preparation according to claim 1, containing as active ingredient a compound according to one of the claims 2 to 4 in connection with a pharmaceutically acceptable carrier material. 9. A pharmaceutical preparation according to any one of claims 7 to 8 in the form of dosage units. 10. Method of treating psychosis in humans. 030556/0038 characterized in that if such treatment is required, an effective amount of a patient is given to a patient Compound of formula ONHCH-2 OR ^XC 2 ^H 5 or a pharmaceutically acceptable salt of the same 1 ' ben, where R is an alkyl group with 1 to 3 carbon 2 3 atoms and R and R are identical or different and each represent a hydrogen atom, chlorine atom or Bromine atom mean administered. 11. The method for the treatment of psychoses according to claim 10, characterized in that "a patient is allowed to undergo such a treatment if necessary an effective amount of a A compound according to any one of claims 2 to 4 administered. j 12. Compounds, processes for their production, intermediates, pharmaceutical preparations and processes for Treatment of psychoses according to claims 1 to 11 including and essentially as described. 030556/0038